Immunoglobulin Light Chains
"Immunoglobulin Light Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.
| Descriptor ID |
D007147
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| MeSH Number(s) |
D12.776.124.486.485.705.750 D12.776.124.790.651.705.750 D12.776.377.715.548.705.750
|
| Concept/Terms |
Immunoglobulin Light Chains- Immunoglobulin Light Chains
- Chains, Immunoglobulin Light
- Light Chains, Immunoglobulin
- Immunoglobulin Light-Chain
- Light-Chain, Immunoglobulin
- Light-Chain Immunoglobulins
- Light Chain Immunoglobulins
- Immunoglobulin Light Chain
- Light Chain, Immunoglobulin
- Immunoglobulins, Light-Chain
- Immunoglobulins, Light Chain
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Light Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Light Chains".
This graph shows the total number of publications written about "Immunoglobulin Light Chains" by people in this website by year, and whether "Immunoglobulin Light Chains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Light Chains" by people in Profiles.
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Schiefner A, Chatwell L, Körner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol. 2011 Dec 2; 414(3):337-55.
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Crowley RW, Sansur CA, Sheehan JP, Mandell JW, Kassell NF, Dumont AS. Intracranial plasmacytoma with apoplectic presentation and spontaneous intracerebral hemorrhage: Case report and review of the literature. Clin Neurol Neurosurg. 2010 Feb; 112(2):172-5.
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Adekar SP, Takahashi T, Jones RM, Al-Saleem FH, Ancharski DM, Root MJ, Kapadnis BP, Simpson LL, Dessain SK. Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain. PLoS One. 2008; 3(8):e3023.
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Lünemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC, Münz C. Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol. 2007 May; 61(5):476-83.
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Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. J Mol Biol. 2004 Sep 17; 342(3):901-12.
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Heltemes-Harris L, Liu X, Manser T. Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype. J Immunol. 2004 Jan 15; 172(2):823-33.
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Magro C, Crowson AN, Porcu P, Nuovo GJ. Automated kappa and lambda light chain mRNA expression for the assessment of B-cell clonality in cutaneous B-cell infiltrates: its utility and diagnostic application. J Cutan Pathol. 2003 Sep; 30(8):504-11.
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Dalakas MC, Cunningham G. Characterization of amyloid deposits in biopsies of 15 with "sporadic" (non-familial or plasma cell dyscrasia amyloid polyneuropathy. Acta Neuropathol. 1986; 69(1-2):66-72.
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Dalakas MC, Engel WK. Immunoglobulin and complement deposits in nerves of patients with chronic relapsing polyneuropathy. Arch Neurol. 1980 Oct; 37(10):637-40.
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Dalakas MC, Engel WK. Role of immunoglobulin light chains in the pathogenesis of amyloid polyneuropathy associated with occult plasma-cell dyscrasia. Trans Am Neurol Assoc. 1979; 104:227-9.