Immunoglobulin Heavy Chains

"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Descriptor ID	D007143
MeSH Number(s)	D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
Concept/Terms	Immunoglobulin Heavy Chains Immunoglobulin Heavy Chains Heavy Chains, Immunoglobulin Ig Heavy Chains Heavy Chains, Ig Immunoglobulins, Heavy-Chain Immunoglobulins, Heavy Chain Heavy-Chain Immunoglobulins Heavy Chain Immunoglobulins Immunoglobulin Heavy Chain Heavy Chain, Immunoglobulin Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH-III Immunoglobulin Heavy Chain Subgroup VH III Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH-I Immunoglobulin Heavy Chain Subgroup VH I

Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Immunoglobulins [D12.776.124.486.485]
Immunoglobulin Subunits [D12.776.124.486.485.705]
Immunoglobulin Heavy Chains [D12.776.124.486.485.705.500]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Immunoglobulin Subunits [D12.776.124.790.651.705]
Immunoglobulin Heavy Chains [D12.776.124.790.651.705.500]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Immunoglobulin Subunits [D12.776.377.715.548.705]
Immunoglobulin Heavy Chains [D12.776.377.715.548.705.500]

Below are MeSH descriptors whose meaning is related to "Immunoglobulin Heavy Chains".

Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.

Bar chart showing 54 publications over 20 distinct years, with a maximum of 7 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	2	3
1997	4	3	7
1998	0	4	4
1999	0	2	2
2000	0	3	3
2001	1	3	4
2002	0	4	4
2003	0	2	2
2004	1	2	3
2005	0	4	4
2006	1	1	2
2007	0	4	4
2008	1	0	1
2009	0	2	2
2010	1	1	2
2013	2	1	3
2014	0	1	1
2015	0	1	1
2017	0	1	1
2022	0	1	1

Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.

Gupta A, Smith P, Bournazos S, Ravetch JV. A novel mouse strain optimized for chronic human antibody administration. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2123002119.

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Liu X, Li YS, Shinton SA, Rhodes J, Tang L, Feng H, Jette CA, Look AT, Hayakawa K, Hardy RR. Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. J Immunol. 2017 09 01; 199(5):1706-1715.

View in: PubMed
Milman T, Kao AA, Chu D, Gorski M, Steiner A, Simon CZ, Shih C, Aldave AJ, Eagle RC, Jakobiec FA, Udell I. Paraproteinemic Keratopathy: The Expanding Diversity of Clinical and Pathologic Manifestations. Ophthalmology. 2015 Sep; 122(9):1748-56.

View in: PubMed
Ichikawa D, Asano M, Shinton SA, Brill-Dashoff J, Formica AM, Velcich A, Hardy RR, Hayakawa K. Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells. J Immunol. 2015 Jan 15; 194(2):606-14.

View in: PubMed
Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet. 2014 Jan; 46(1):8-10.

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Lu J, Panavas T, Thys K, Aerssens J, Naso M, Fisher J, Rycyzyn M, Sweet RW. IgG variable region and VH CDR3 diversity in unimmunized mice analyzed by massively parallel sequencing. Mol Immunol. 2014 Feb; 57(2):274-83.

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Fertala J, Steplewski A, Kostas J, Beredjiklian P, Williams G, Arnold W, Abboud J, Bhardwaj A, Hou C, Fertala A. Engineering and characterization of the chimeric antibody that targets the C-terminal telopeptide of the a2 chain of human collagen I: a next step in the quest to reduce localized fibrosis. Connect Tissue Res. 2013; 54(3):187-96.

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Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010 Sep 30; 467(7315):591-5.

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Anthony RM, Ravetch JV. A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs. J Clin Immunol. 2010 May; 30 Suppl 1:S9-14.

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Pozdnyakova O, Spieler PJ, Abraham J, Freedman AS, Kutok JL. Epstein-barr virus-associated diffuse large B-cell lymphoma in an immunocompetent woman. J Clin Oncol. 2010 Feb 10; 28(5):e75-8.

View in: PubMed

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