Megakaryocytes

"Megakaryocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.

Descriptor ID	D008533
MeSH Number(s)	A11.148.479 A15.378.316.479
Concept/Terms	Megakaryocytes Megakaryocytes Megakaryocyte

Below are MeSH descriptors whose meaning is more general than "Megakaryocytes".

Anatomy [A]
Cells [A11]
Bone Marrow Cells [A11.148]
Megakaryocytes [A11.148.479]
Hemic and Immune Systems [A15]
Hematopoietic System [A15.378]
Bone Marrow Cells [A15.378.316]
Megakaryocytes [A15.378.316.479]

Below are MeSH descriptors whose meaning is related to "Megakaryocytes".

Below are MeSH descriptors whose meaning is more specific than "Megakaryocytes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Megakaryocytes" by people in this website by year, and whether "Megakaryocytes" was a major or minor topic of these publications.

Bar chart showing 69 publications over 27 distinct years, with a maximum of 5 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	0	2
1997	1	0	1
1998	2	0	2
1999	0	1	1
2000	2	0	2
2001	3	1	4
2002	1	0	1
2003	1	1	2
2006	1	0	1
2007	4	0	4
2008	3	0	3
2009	2	0	2
2011	4	1	5
2012	2	2	4
2013	2	1	3
2014	2	2	4
2015	3	1	4
2016	3	1	4
2017	0	2	2
2018	3	0	3
2019	4	0	4
2020	2	0	2
2021	2	0	2
2022	2	0	2
2023	0	1	1
2024	1	2	3
2025	1	0	1

Below are the most recent publications written about "Megakaryocytes" by people in Profiles.

Lazar S, Wurtzel JGT, Askari S, Cooper M, Zhao X, Ma P, Goldfinger LE. Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity. Sci Rep. 2025 01 28; 15(1):3590.

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Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg EC. An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. Cell. 2024 Jun 06; 187(12):3090-3107.e21.

View in: PubMed
Del Carpio-Cano F, Mao G, Goldfinger LE, Wurtzel J, Guan L, Alam MA, Lee K, Poncz M, Rao AK. Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency. Blood Adv. 2024 04 09; 8(7):1699-1714.

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Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray PF. Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. Haematologica. 2024 01 01; 109(1):331-336.

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Nersisyan S, Montenont E, Loher P, Middleton EA, Campbell R, Bray P, Rigoutsos I. Characterization of all small RNAs in and comparisons across cultured megakaryocytes and platelets of healthy individuals and COVID-19 patients. J Thromb Haemost. 2023 11; 21(11):3252-3267.

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Jalagadugula G, Mao G, Goldfinger LE, Wurtzel J, Del Carpio-Cano F, Lambert MP, Estevez B, French DL, Poncz M, Rao AK. Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency. Blood Adv. 2022 09 13; 6(17):5100-5112.

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Bhatlekar S, Jacob S, Tugolukova E, Manne BK, Kosaka Y, Loher P, O'Connell RM, Planelles V, Rondina MT, Rigoutsos I, Bray PF. Interferon a-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation. Haematologica. 2022 02 01; 107(2):558-561.

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Bhatlekar S, Jacob S, Manne BK, Guo L, Denorme F, Tugolukova EA, Cody MJ, Kosaka Y, Rigoutsos I, Campbell RA, Rowley JW, O'Connell RM, Bray PF. Megakaryocyte-specific knockout of the Mir-99b/let7e/125a cluster lowers platelet count without altering platelet function. Blood Cells Mol Dis. 2021 12; 92:102624.

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Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, Bray PF, Rowley JW. CRISPR-edited megakaryocytes for rapid screening of platelet gene functions. Blood Adv. 2021 05 11; 5(9):2362-2374.

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Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood. 2020 10 08; 136(15):1760-1772.

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