Parkinson Disease

"Parkinson Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Descriptor ID	D010300
MeSH Number(s)	C10.228.140.079.862.500 C10.228.662.600.400 C10.574.812
Concept/Terms	Parkinson Disease Parkinson Disease Idiopathic Parkinson's Disease Lewy Body Parkinson Disease Lewy Body Parkinson's Disease Primary Parkinsonism Parkinsonism, Primary Parkinson Disease, Idiopathic Parkinson's Disease Parkinson's Disease, Idiopathic Parkinson's Disease, Lewy Body Idiopathic Parkinson Disease Paralysis Agitans

Below are MeSH descriptors whose meaning is more general than "Parkinson Disease".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Basal Ganglia Diseases [C10.228.140.079]
Parkinsonian Disorders [C10.228.140.079.862]
Parkinson Disease [C10.228.140.079.862.500]
Movement Disorders [C10.228.662]
Parkinsonian Disorders [C10.228.662.600]
Parkinson Disease [C10.228.662.600.400]
Neurodegenerative Diseases [C10.574]
Parkinson Disease [C10.574.812]

Below are MeSH descriptors whose meaning is related to "Parkinson Disease".

Below are MeSH descriptors whose meaning is more specific than "Parkinson Disease".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Parkinson Disease" by people in this website by year, and whether "Parkinson Disease" was a major or minor topic of these publications.

Bar chart showing 107 publications over 22 distinct years, with a maximum of 9 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2003	2	1	3
2004	2	2	4
2005	6	2	8
2006	7	0	7
2007	3	1	4
2008	3	3	6
2009	6	1	7
2010	8	1	9
2011	4	0	4
2012	6	0	6
2013	5	0	5
2014	8	0	8
2015	6	0	6
2016	6	0	6
2017	4	0	4
2018	3	1	4
2020	2	0	2
2021	4	0	4
2022	2	0	2
2023	3	0	3
2024	2	2	4

Below are the most recent publications written about "Parkinson Disease" by people in Profiles.

Jiang C, Li Y, Duan K, Zhan T, Chen Z, Wang Y, Zhao R, Ma C, Guo Y, Liu C. [Parkin deletion affects PINK1/Parkin-mediated mitochondrial autophagy to exacerbate neuroinflammation and accelerate progression of Parkinson's disease in mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Dec 20; 44(12):2359-2366.

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Gusovsky AV, Lin CC, Kerber K, Reynolds EL, Callaghan BC, Burke JF. Costs Are Still on the Rise for Commonly Prescribed Branded Neurologic Medications. Neurology. 2024 Nov 26; 103(10):e210029.

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Lu Q, Zhu Z, Zhang H, Gan C, Shan A, Gao M, Sun H, Cao X, Yuan Y, Tracy JI, Zhang Q, Zhang K. Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease. Transl Psychiatry. 2024 Aug 30; 14(1):347.

View in: PubMed
Cheslow L, Snook AE, Waldman SA. Biomarkers for Managing Neurodegenerative Diseases. Biomolecules. 2024 Mar 26; 14(4).

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Isaacson SH, Kremens D, Torres-Yaghi Y, Stocchi F, Antonini A. Importance of time to ON versus wearing OFF in total daily OFF time experienced by patients with Parkinson's disease. Parkinsonism Relat Disord. 2023 09; 114:105495.

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Schneider JS. GM1 Ganglioside as a Disease-Modifying Therapeutic for Parkinson's Disease: A Multi-Functional Glycosphingolipid That Targets Multiple Parkinson's Disease-Relevant Pathogenic Mechanisms. Int J Mol Sci. 2023 May 24; 24(11).

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Miller CPK, Muller J, Noecker AM, Matias C, Alizadeh M, McIntyre C, Wu C. Automatic Segmentation of Parkinson Disease Therapeutic Targets Using Nonlinear Registration and Clinical MR Imaging: Comparison of Methodology, Presence of Disease, and Quality Control. Stereotact Funct Neurosurg. 2023; 101(2):146-157.

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Thompson ED, Reisman DS. Split-Belt Adaptation and Savings in People With Parkinson Disease. J Neurol Phys Ther. 2022 10 01; 46(4):293-301.

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Osborne JA, Botkin R, Colon-Semenza C, DeAngelis TR, Gallardo OG, Kosakowski H, Martello J, Pradhan S, Rafferty M, Readinger JL, Whitt AL, Ellis TD. Physical Therapist Management of Parkinson Disease: A Clinical Practice Guideline From the American Physical Therapy Association. Phys Ther. 2022 04 01; 102(4).

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Pringsheim T, Day GS, Smith DB, Rae-Grant A, Licking N, Armstrong MJ, de Bie RMA, Roze E, Miyasaki JM, Hauser RA, Espay AJ, Martello JP, Gurwell JA, Billinghurst L, Sullivan K, Fitts MS, Cothros N, Hall DA, Rafferty M, Hagerbrant L, Hastings T, O'Brien MD, Silsbee H, Gronseth G, Lang AE. Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary: A Report of the AAN Guideline Subcommittee. Neurology. 2021 11 16; 97(20):942-957.

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