"TDP-43 Proteinopathies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
| Descriptor ID |
D057177
|
| MeSH Number(s) |
C10.574.950 C18.452.845.800
|
| Concept/Terms |
TDP-43 Proteinopathies- TDP-43 Proteinopathies
- Proteinopathies, TDP-43
- Proteinopathy, TDP-43
- TDP 43 Proteinopathies
- TDP-43 Proteinopathy
|
Below are MeSH descriptors whose meaning is more general than "TDP-43 Proteinopathies".
Below are MeSH descriptors whose meaning is more specific than "TDP-43 Proteinopathies".
This graph shows the total number of publications written about "TDP-43 Proteinopathies" by people in this website by year, and whether "TDP-43 Proteinopathies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "TDP-43 Proteinopathies" by people in Profiles.
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Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain. 2018 07 01; 141(7):2181-2193.
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Ferraro PM, Jester C, Olm CA, Placek K, Agosta F, Elman L, McCluskey L, Irwin DJ, Detre JA, Filippi M, Grossman M, McMillan CT. Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies. Neurobiol Aging. 2018 08; 68:85-92.
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Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, Feldengut S, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol. 2013 Jul; 74(1):20-38.
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Tong J, Huang C, Bi F, Wu Q, Huang B, Zhou H. XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats. J Neurochem. 2012 Nov; 123(3):406-16.
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Huang C, Tong J, Bi F, Zhou H, Xia XG. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats. J Clin Invest. 2012 Jan; 122(1):107-18.