Richard Smeyne

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address900 Walnut Street
Philadelphia PA 19107
Phone215-955-8634
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smeyne RJ. In memorium, Michael Zigmond, PhD. NPJ Parkinsons Dis. 2023 Nov 01; 9(1):151. PMID: 37914702.
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    2. Cheslow L, Byrne M, Kopenhaver JS, Iacovitti L, Smeyne RJ, Snook AE, Waldman SA. GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults. Res Sq. 2023 Oct 13. PMID: 37886524.
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    3. Heng V, Zigmond M, Smeyne RJ. Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice. Front Neuroanat. 2023; 17:1190291. PMID: 37662476.
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    4. Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB. Microglia-specific knock-out of NF-?B/IKK2 increases the accumulation of misfolded a-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. Glia. 2023 May 18. PMID: 37199240.
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    5. Chen PC, Han X, Shaw TI, Fu Y, Sun H, Niu M, Wang Z, Jiao Y, Teubner BJW, Eddins D, Beloate LN, Bai B, Mertz J, Li Y, Cho JH, Wang X, Wu Z, Liu D, Poudel S, Yuan ZF, Mancieri A, Low J, Lee HM, Patton MH, Earls LR, Stewart E, Vogel P, Hui Y, Wan S, Bennett DA, Serrano GE, Beach TG, Dyer MA, Smeyne RJ, Moldoveanu T, Chen T, Wu G, Zakharenko SS, Yu G, Peng J. Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nat Aging. 2022 Oct; 2(10):923-940. PMID: 36636325.
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    6. Smeyne RJ, Eells JB, Chatterjee D, Byrne M, Akula SM, Sriramula S, O'Rourke DP, Schmidt P. COVID-19 infection enhances susceptibility to oxidative-stress induced parkinsonism. Mov Disord. 2022 May 17. PMID: 35579496.
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    7. Kozina E, Byrne M, Smeyne RJ. Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson's disease. NPJ Parkinsons Dis. 2022 Mar 15; 8(1):24. PMID: 35292674.
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    8. Rocha SM, Bantle CM, Aboellail T, Chatterjee D, Smeyne RJ, Tjalkens RB. Rotenone induces regionally distinct a-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice. Neurobiol Dis. 2022 Mar 05; 167:105685. PMID: 35257879.
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    9. Bantle CM, Rocha SM, French CT, Phillips AT, Tran K, Olson KE, Bass TA, Aboellail T, Smeyne RJ, Tjalkens RB. Astrocyte inflammatory signaling mediates a-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis. Exp Neurol. 2021 Dec; 346:113845. PMID: 34454938.
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    10. Oakes HV, McWethy D, Ketchem S, Tran L, Phillips K, Oakley L, Smeyne RJ, Pond BB. Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism. Neurotox Res. 2021 Jun; 39(3):667-676. PMID: 33666887.
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    11. Bantle CM, French CT, Cummings JE, Sadasivan S, Tran K, Slayden RA, Smeyne RJ, Tjalkens RB. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021; 16(1):e0245171. PMID: 33493177.
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    12. Smeyne RJ, Noyce AJ, Byrne M, Savica R, Marras C. Infection and Risk of Parkinson's Disease. J Parkinsons Dis. 2020 Dec 22. PMID: 33361610.
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    13. Sulzer D, Antonini A, Leta V, Nordvig A, Smeyne RJ, Goldman JE, Al-Dalahmah O, Zecca L, Sette A, Bubacco L, Meucci O, Moro E, Harms AS, Xu Y, Fahn S, Ray Chaudhuri K. COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside. NPJ Parkinsons Dis. 2020; 6:18. PMID: 32885037.
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    14. Bantle CM, Phillips AT, Smeyne RJ, Rocha SM, Olson KE, Tjalkens RB. Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. NPJ Parkinsons Dis. 2019; 5:20. PMID: 31531390.
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    15. Murphy KL, Fischer R, Swanson KA, Bhatt IJ, Oakley L, Smeyne R, Bracchi-Ricard V, Bethea JR. Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis. Exp Neurol. 2019 Sep 06; 113061. PMID: 31499065.
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    16. Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Struct Funct. 2019 Nov; 224(8):2983-2999. PMID: 31485718.
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    17. Fischer R, Padutsch T, Bracchi-Ricard V, Murphy KL, Martinez GF, Delguercio N, Elmer N, Sendetski M, Diem R, Eisel ULM, Smeyne RJ, Kontermann RE, Pfizenmaier K, Bethea JR. Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain Behav Immun. 2019 Jun 17. PMID: 31220564.
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    18. Yang J, Simonneau C, Kilker R, Oakley L, Byrne MD, Nichtova Z, Stefanescu I, Pardeep-Kumar F, Tripathi S, Londin E, Saugier-Veber P, Willard B, Thakur M, Pickup S, Ishikawa H, Schroten H, Smeyne R, Horowitz A. Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus. EMBO Mol Med. 2019 Jan; 11(1). PMID: 30518636.
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    19. Kozina E, Sadasivan S, Jiao Y, Dou Y, Ma Z, Tan H, Kodali K, Shaw T, Peng J, Smeyne RJ. Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo. Brain. 2018 Jun 01; 141(6):1753-1769. PMID: 29800472.
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    20. Blundon JA, Roy NC, Teubner BJW, Yu J, Eom TY, Sample KJ, Pani A, Smeyne RJ, Han SB, Kerekes RA, Rose DC, Hackett TA, Vuppala PK, Freeman BB, Zakharenko SS. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science. 2017 Jun 30; 356(6345):1352-1356. PMID: 28663494.
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    21. Sadasivan S, Sharp B, Schultz-Cherry S, Smeyne RJ. Synergistic effects of influenza and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be eliminated by the use of influenza therapeutics: experimental evidence for the multi-hit hypothesis. NPJ Parkinsons Dis. 2017; 3:18. PMID: 28649618.
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    22. Smeyne RJ, Breckenridge CB, Beck M, Jiao Y, Butt MT, Wolf JC, Zadory D, Minnema DJ, Sturgess NC, Travis KZ, Cook AR, Smith LL, Botham PA. Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice. PLoS One. 2016; 11(10):e0164094. PMID: 27788145.
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    23. Humann J, Mann B, Gao G, Moresco P, Ramahi J, Loh LN, Farr A, Hu Y, Durick-Eder K, Fillon SA, Smeyne RJ, Tuomanen EI. Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe. 2016 Jun 08; 19(6):901. PMID: 27281575.
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    24. Humann J, Mann B, Gao G, Moresco P, Ramahi J, Loh LN, Farr A, Hu Y, Durick-Eder K, Fillon SA, Smeyne RJ, Tuomanen EI. Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host Microbe. 2016 Mar 09; 19(3):388-99. PMID: 26962947.
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    25. Gingras S, Earls LR, Howell S, Smeyne RJ, Zakharenko SS, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22; 35(29):10510-22. PMID: 26203146.
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    26. Sadasivan S, Zanin M, O'Brien K, Schultz-Cherry S, Smeyne RJ. Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus. PLoS One. 2015; 10(4):e0124047. PMID: 25861024.
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    27. Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ. HIF1a is necessary for exercise-induced neuroprotection while HIF2a is needed for dopaminergic neuron survival in the substantia nigra pars compacta. Neuroscience. 2015 Jun 04; 295:23-38. PMID: 25796140; PMCID: PMC4524512.
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    28. Tian J, Tep C, Benedick A, Saidi N, Ryu JC, Kim ML, Sadasivan S, Oberdick J, Smeyne R, Zhu MX, Yoon SO. p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1. J Biol Chem. 2014 Nov 07; 289(45):31458-72. PMID: 25253694.
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    29. Chun S, Westmoreland JJ, Bayazitov IT, Eddins D, Pani AK, Smeyne RJ, Yu J, Blundon JA, Zakharenko SS. Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models. Science. 2014 Jun 6; 344(6188):1178-82. PMID: 24904170.
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    30. Pani AK, Jiao Y, Sample KJ, Smeyne RJ. Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice. PLoS One. 2014; 9(3):e92422. PMID: 24642754.
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    31. Zigmond MJ, Smeyne RJ. Exercise: is it a neuroprotective and if so, how does it work? Parkinsonism Relat Disord. 2014 Jan; 20 Suppl 1:S123-7. PMID: 24262162.
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    32. Smeyne M, Smeyne RJ. Glutathione metabolism and Parkinson's disease. Free Radic Biol Med. 2013 Sep; 62:13-25. PMID: 23665395.
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    33. Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM. Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. PLoS One. 2012; 7(11):e50040. PMID: 23209637.
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    34. Muldoon LL, Alvarez JI, Begley DJ, Boado RJ, Del Zoppo GJ, Doolittle ND, Engelhardt B, Hallenbeck JM, Lonser RR, Ohlfest JR, Prat A, Scarpa M, Smeyne RJ, Drewes LR, Neuwelt EA. Immunologic privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab. 2013 Jan; 33(1):13-21. PMID: 23072749.
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    35. Gerecke KM, Jiao Y, Pagala V, Smeyne RJ. Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice. PLoS One. 2012; 7(8):e43250. PMID: 22912838.
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    36. Heyer MP, Pani AK, Smeyne RJ, Kenny PJ, Feng G. Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice. J Neurosci. 2012 Aug 8; 32(32):10887-94. PMID: 22875923.
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    37. Pattarini R, Rong Y, Shepherd KR, Jiao Y, Qu C, Smeyne RJ, Morgan JI. Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine. Neuroscience. 2012 Jul 12; 214:84-105. PMID: 22542874; PMCID: PMC3371097.
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    38. Sadasivan S, Pond BB, Pani AK, Qu C, Jiao Y, Smeyne RJ. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice. PLoS One. 2012; 7(3):e33693. PMID: 22470460.
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    39. Jang H, Boltz D, McClaren J, Pani AK, Smeyne M, Korff A, Webster R, Smeyne RJ. Inflammatory effects of highly pathogenic H5N1 influenza virus infection in the CNS of mice. J Neurosci. 2012 Feb 01; 32(5):1545-59. PMID: 22302798.
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    40. Jiao Y, Lu L, Williams RW, Smeyne RJ. Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta. PLoS One. 2012; 7(1):e29447. PMID: 22291891.
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    41. Zigmond MJ, Cameron JL, Hoffer BJ, Smeyne RJ. Neurorestoration by physical exercise: moving forward. Parkinsonism Relat Disord. 2012 Jan; 18 Suppl 1:S147-50. PMID: 22166417.
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    42. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75. PMID: 21840489.
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    43. Korff A, Pfeiffer B, Smeyne M, Kocak M, Pfeiffer RF, Smeyne RJ. Alterations in glutathione S-transferase pi expression following exposure to MPP+ -induced oxidative stress in the blood of Parkinson's disease patients. Parkinsonism Relat Disord. 2011 Dec; 17(10):765-8. PMID: 21840241.
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    44. Lloyd SA, Balest ZR, Corotto FS, Smeyne RJ. Cocaine selectively increases proliferation in the adult murine hippocampus. Neurosci Lett. 2010 Nov 19; 485(2):112-6. PMID: 20817079.
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    45. Henry J, Smeyne RJ, Jang H, Miller B, Okun MS. Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. Parkinsonism Relat Disord. 2010 Nov; 16(9):566-71. PMID: 20650672.
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    46. Zigmond M, Smeyne RJ. Foreword: exercise and the brain. Brain Res. 2010 Jun 23; 1341:1-2. PMID: 20538145.
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    47. Burton AR, Baquet Z, Eisenbarth GS, Tisch R, Smeyne R, Workman CJ, Vignali DA. Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol. 2010 May 1; 184(9):4863-70. PMID: 20348424.
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    48. Gerecke KM, Jiao Y, Pani A, Pagala V, Smeyne RJ. Exercise protects against MPTP-induced neurotoxicity in mice. Brain Res. 2010 Jun 23; 1341:72-83. PMID: 20116369.
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    49. Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 1; 19(9):1633-50. PMID: 20106867.
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    50. Zigmond MJ, Cameron JL, Leak RK, Mirnics K, Russell VA, Smeyne RJ, Smith AD. Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency. Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S42-5. PMID: 20083005.
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    51. Jang H, Boltz D, Sturm-Ramirez K, Shepherd KR, Jiao Y, Webster R, Smeyne RJ. Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14063-8. PMID: 19667183.
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    52. Baquet ZC, Williams D, Brody J, Smeyne RJ. A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse. Neuroscience. 2009 Jul 21; 161(4):1082-90. PMID: 19376196; PMCID: PMC2705113.
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    53. Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2933-8. PMID: 19196989.
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    54. Jang H, Boltz DA, Webster RG, Smeyne RJ. Viral parkinsonism. Biochim Biophys Acta. 2009 Jul; 1792(7):714-21. PMID: 18760350.
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    55. Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol. 2008 Jun; 9(6):658-66. PMID: 18469818.
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    56. Wei P, Smeyne RJ, Bao D, Parris J, Morgan JI. Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons. Eur J Neurosci. 2007 Nov; 26(10):2962-78. PMID: 18001291.
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    57. Boyd JD, Jang H, Shepherd KR, Faherty C, Slack S, Jiao Y, Smeyne RJ. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain Res. 2007 Oct 17; 1175:107-16. PMID: 17884023.
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    58. Smeyne RJ. Catalog of the Neurological Mutants of Mouse revisited: honoring the 40th anniversary of its initial publication. Brain Res. 2007 Apr 6; 1140:1. PMID: 17288997.
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    59. Smeyne M, Boyd J, Raviie Shepherd K, Jiao Y, Pond BB, Hatler M, Wolf R, Henderson C, Smeyne RJ. GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc Natl Acad Sci U S A. 2007 Feb 6; 104(6):1977-82. PMID: 17267597.
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    60. Pattarini R, Smeyne RJ, Morgan JI. Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease. Neuroscience. 2007 Mar 16; 145(2):654-68. PMID: 17258864; PMCID: PMC1894756.
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    61. Lloyd SA, Faherty CJ, Smeyne RJ. Adult and in utero exposure to cocaine alters sensitivity to the Parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience. 2006 Feb; 137(3):905-13. PMID: 16298078.
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    62. Smeyne M, Jiao Y, Shepherd KR, Smeyne RJ. Glia cell number modulates sensitivity to MPTP in mice. Glia. 2005 Nov 1; 52(2):144-52. PMID: 15920722.
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    63. Johnson DK, Rinchik EM, Moustaid-Moussa N, Miller DR, Williams RW, Michaud EJ, Jablonski MM, Elberger A, Hamre K, Smeyne R, Chesler E, Goldowitz D. Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age (Dordr). 2005 Mar; 27(1):75-90. PMID: 23598606.
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    64. Faherty CJ, Raviie Shepherd K, Herasimtschuk A, Smeyne RJ. Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):170-9. PMID: 15790541.
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    65. Smeyne RJ, Jackson-Lewis V. The MPTP model of Parkinson's disease. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):57-66. PMID: 15790530.
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    66. Jackson-Lewis V, Smeyne RJ. MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview. Neurotox Res. 2005; 7(3):193-202. PMID: 15897154.
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    67. Lewis PM, Gritli-Linde A, Smeyne R, Kottmann A, McMahon AP. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004 Jun 15; 270(2):393-410. PMID: 15183722.
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    68. Jensen P, Smeyne R, Goldowitz D. Analysis of cerebellar development in math1 null embryos and chimeras. J Neurosci. 2004 Mar 3; 24(9):2202-11. PMID: 14999071.
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    69. Lloyd SA, Wensley B, Faherty CJ, Smeyne RJ. Regional differences in cortical dendrite morphology following in utero exposure to cocaine. Brain Res Dev Brain Res. 2003 Dec 30; 147(1-2):59-66. PMID: 14741751.
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    70. Zindy F, Nilsson LM, Nguyen L, Meunier C, Smeyne RJ, Rehg JE, Eberhart C, Sherr CJ, Roussel MF. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice. Cancer Res. 2003 Sep 1; 63(17):5420-7. PMID: 14500377.
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    71. Faherty CJ, Kerley D, Smeyne RJ. A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Brain Res Dev Brain Res. 2003 Mar 14; 141(1-2):55-61. PMID: 12644248.
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    72. Cook R, Lu L, Gu J, Williams RW, Smeyne RJ. Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res. 2003 Feb 20; 110(2):279-88. PMID: 12591164.
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    73. Smeyne M, Smeyne RJ. Method for culturing postnatal substantia nigra as an in vitro model of experimental Parkinson's disease. Brain Res Brain Res Protoc. 2002 Apr; 9(2):105-11. PMID: 12034329.
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    74. McKeller RN, Fowler JL, Cunningham JJ, Warner N, Smeyne RJ, Zindy F, Skapek SX. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3848-53. PMID: 11891301.
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    75. Cunningham JJ, Levine EM, Zindy F, Goloubeva O, Roussel MF, Smeyne RJ. The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit. Mol Cell Neurosci. 2002 Mar; 19(3):359-74. PMID: 11906209.
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    76. Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet. 2001 Dec; 29(4):404-11. PMID: 11726927.
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    77. Smeyne M, Goloubeva O, Smeyne RJ. Strain-dependent susceptibility to MPTP and MPP(+)-induced parkinsonism is determined by glia. Glia. 2001 Apr 15; 34(2):73-80. PMID: 11307156.
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    78. Chen SC, Cunningham JJ, Smeyne RJ. Expression of OB receptor splice variants during prenatal development of the mouse. J Recept Signal Transduct Res. 2000 Jan; 20(1):87-103. PMID: 10711499.
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    79. Zindy F, Cunningham JJ, Sherr CJ, Jogal S, Smeyne RJ, Roussel MF. Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13462-7. PMID: 10557343; PMCID: PMC23970.
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    80. Faherty CJ, Xanthoudakis S, Smeyne RJ. Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment. Brain Res Mol Brain Res. 1999 Jun 18; 70(1):159-63. PMID: 10381555.
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    81. Hamre K, Tharp R, Poon K, Xiong X, Smeyne RJ. Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus. Brain Res. 1999 May 15; 828(1-2):91-103. PMID: 10320728.
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    82. Rottier RJ, Hahn CN, Mann LW, del Pilar Martin M, Smeyne RJ, Suzuki K, d'Azzo A. Lack of PPCA expression only partially coincides with lysosomal storage in galactosialidosis mice: indirect evidence for spatial requirement of the catalytic rather than the protective function of PPCA. Hum Mol Genet. 1998 Oct; 7(11):1787-94. PMID: 9736781.
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    83. Rice FL, Albers KM, Davis BM, Silos-Santiago I, Wilkinson GA, LeMaster AM, Ernfors P, Smeyne RJ, Aldskogius H, Phillips HS, Barbacid M, DeChiara TM, Yancopoulos GD, Dunne CE, Fundin BT. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol. 1998 Jun 01; 198(1):57-81. PMID: 9640332.
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    84. Chen SC, Ehrhard P, Goldowitz D, Smeyne RJ. Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Brain Res. 1997 Dec 19; 778(2):251-64. PMID: 9459542.
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    85. Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, Nienhuis AW. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood. 1997 Sep 01; 90(5):1777-86. PMID: 9292510.
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    86. Vassileva G, Smeyne RJ, Morgan JI. Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice. Brain Res Mol Brain Res. 1997 Jun; 46(1-2):333-7. PMID: 9191112.
      Citations:    
    87. Morgan JI, Smeyne RJ. Transgenic approaches to cerebellar development. Perspect Dev Neurobiol. 1997; 5(1):33-41. PMID: 9509516.
      Citations:    
    88. Paradies MA, Grishkat H, Smeyne RJ, Oberdick J, Morgan JI, Eisenman LM. Correspondence between L7-lacZ-expressing Purkinje cells and labeled olivocerebellar fibers during late embryogenesis in the mouse. J Comp Neurol. 1996 Oct 21; 374(3):451-66. PMID: 8906510.
      Citations:    
    89. Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J Neurosci. 1996 Oct 01; 16(19):6208-18. PMID: 8815902.
      Citations:    
    90. Kasof GM, Smeyne RJ, Curran T, Morgan JI. Developmental expression of Fos-lacZ in the brains of postnatal transgenic rats. Brain Res Dev Brain Res. 1996 May 31; 93(1-2):191-7. PMID: 8804706.
      Citations:    
    91. Goldowitz D, Smeyne RJ. Tune into the weaver channel. Nat Genet. 1995 Oct; 11(2):107-9. PMID: 7550328.
      Citations:    
    92. Silos-Santiago I, Molliver DC, Ozaki S, Smeyne RJ, Fagan AM, Barbacid M, Snider WD. Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice. J Neurosci. 1995 Sep; 15(9):5929-42. PMID: 7666178.
      Citations:    
    93. Smeyne RJ, Chu T, Lewin A, Bian F, Sanlioglu S, S-Crisman S, Kunsch C, Lira SA, Oberdick J. Local control of granule cell generation by cerebellar Purkinje cells. Mol Cell Neurosci. 1995 Jun; 6(3):230-51. PMID: 7496629.
      Citations:    
    94. Robertson LM, Kerppola TK, Vendrell M, Luk D, Smeyne RJ, Bocchiaro C, Morgan JI, Curran T. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron. 1995 Feb; 14(2):241-52. PMID: 7857636.
      Citations:    
    95. Miao GG, Smeyne RJ, D'Arcangelo G, Copeland NG, Jenkins NA, Morgan JI, Curran T. Isolation of an allele of reeler by insertional mutagenesis. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):11050-4. PMID: 7972007; PMCID: PMC45164.
      Citations:    
    96. Oberdick J, Schilling K, Smeyne RJ, Corbin JG, Bocchiaro C, Morgan JI. Control of segment-like patterns of gene expression in the mouse cerebellum. Neuron. 1993 Jun; 10(6):1007-18. PMID: 8318226.
      Citations:    
    97. Molinar-Rode R, Smeyne RJ, Curran T, Morgan JI. Regulation of proto-oncogene expression in adult and developing lungs. Mol Cell Biol. 1993 Jun; 13(6):3213-20. PMID: 8497249; PMCID: PMC359765.
      Citations:    
    98. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson LM, Curran T, Morgan JI. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 1993 May 13; 363(6425):166-9. PMID: 8483500.
      Citations:    
    99. Smeyne RJ, Schilling K, Oberdick J, Robertson L, Luk D, Curran T, Morgan JI. A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping. Adv Neurol. 1993; 59:285-91. PMID: 8420113.
      Citations:    
    100. Smeyne RJ, Curran T, Morgan JI. Temporal and spatial expression of a fos-lacZ transgene in the developing nervous system. Brain Res Mol Brain Res. 1992 Nov; 16(1-2):158-62. PMID: 1334194.
      Citations:    
    101. Smeyne RJ, Schilling K, Robertson L, Luk D, Oberdick J, Curran T, Morgan JI. fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. Neuron. 1992 Jan; 8(1):13-23. PMID: 1730004.
      Citations:    
    102. Smeyne RJ, Oberdick J, Schilling K, Berrebi AS, Mugnaini E, Morgan JI. Dynamic organization of developing Purkinje cells revealed by transgene expression. Science. 1991 Nov 01; 254(5032):719-21. PMID: 1948052.
      Citations:    
    103. Smeyne RJ, Pickford LB, Rouse RV, Napieralski J, Goldowitz D. Abnormalities in premigratory granule cells in the weaver cerebellum defined by monoclonal antibody OZ42. Anat Embryol (Berl). 1991; 183(3):213-9. PMID: 2042747.
      Citations:    
    104. Smeyne RJ, Goldowitz D. Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Brain Res Dev Brain Res. 1990 Jul 01; 54(2):282-6. PMID: 2397591.
      Citations:    
    105. Oberdick J, Smeyne RJ, Mann JR, Zackson S, Morgan JI. A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons. Science. 1990 Apr 13; 248(4952):223-6. PMID: 2109351.
      Citations:    
    106. Smeyne RJ, Goldowitz D. Purkinje cell loss is due to a direct action of the weaver gene in Purkinje cells: evidence from chimeric mice. Brain Res Dev Brain Res. 1990 Mar 01; 52(1-2):211-8. PMID: 2331788.
      Citations:    
    107. Reeves RH, Crowley MR, Lorenzon N, Pavan WJ, Smeyne RJ, Goldowitz D. The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics. 1989 Oct; 5(3):522-6. PMID: 2575584.
      Citations:    
    108. Smeyne RJ, Goldowitz D. Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study. J Neurosci. 1989 May; 9(5):1608-20. PMID: 2723742.
      Citations:    
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