Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 465 publications over 30 distinct years, with a maximum of 34 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	8	8
1997	0	6	6
1998	0	9	9
1999	0	11	11
2000	0	9	9
2001	0	12	12
2002	0	24	24
2003	1	24	25
2004	0	23	23
2005	0	26	26
2006	0	21	21
2007	0	23	23
2008	0	22	22
2009	1	15	16
2010	1	19	20
2011	0	17	17
2012	0	23	23
2013	0	34	34
2014	0	18	18
2015	0	26	26
2016	1	21	22
2017	0	19	19
2018	0	7	7
2019	0	12	12
2020	0	8	8
2021	0	10	10
2022	0	2	2
2023	0	2	2
2024	1	7	8
2025	0	2	2

Below are the most recent publications written about "Protein Binding" by people in Profiles.

Cheng SJ, Gafaar T, Kuttiyatveetil JRA, Sverzhinsky A, Chen C, Xu M, Lilley A, Pascal JM, Leung AKL. Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13. Nat Commun. 2025 Jan 13; 16(1):621.

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Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

View in: PubMed
Valerie NCK, Sanjiv K, Mortusewicz O, Zhang SM, Alam S, Pires MJ, Stigsdotter H, Rasti A, Langelier MF, Rehling D, Throup A, Purewal-Sidhu O, Desroses M, Onireti J, Wakchaure P, Alml?f I, Bostr?m J, Bevc L, Benzi G, Stenmark P, Pascal JM, Helleday T, Page BDG, Altun M. Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM. Nat Commun. 2024 12 06; 15(1):10347.

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Shinkai A, Hashimoto H, Shimura C, Fujimoto H, Fukuda K, Horikoshi N, Okano M, Niwa H, Debler EW, Kurumizaka H, Shinkai Y. The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS. Nucleic Acids Res. 2024 09 23; 52(17):10194-10219.

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Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 09 10; 15(1):7887.

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Vukovic I, Barnada SM, Ruffin JW, Karlin J, Lokareddy RK, Cingolani G, McMahon SB. Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b. Life Sci Alliance. 2024 11; 7(11).

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Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT. Structural basis for a Pol? helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 08 14; 15(1):7003.

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Kalabekova R, Quinn CM, Movellan KT, Gronenborn AM, Akke M, Polenova T. 19F Fast Magic-Angle Spinning NMR Spectroscopy on Microcrystalline Complexes of Fluorinated Ligands and the Carbohydrate Recognition Domain of Galectin-3. Biochemistry. 2024 09 03; 63(17):2207-2216.

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Freidel MR, Armen RS. Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike. Viruses. 2024 04 30; 16(5).

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Freidel MR, Vakhariya PA, Sardarni SK, Armen RS. The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein. Viruses. 2024 04 20; 16(4).

View in: PubMed

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