Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 937 publications over 30 distinct years, with a maximum of 56 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	13	13
1997	0	13	13
1998	0	15	15
1999	0	23	23
2000	0	29	29
2001	0	27	27
2002	0	49	49
2003	1	53	54
2004	0	40	40
2005	0	49	49
2006	0	44	44
2007	0	42	42
2008	0	48	48
2009	1	44	45
2010	1	38	39
2011	0	37	37
2012	0	45	45
2013	0	56	56
2014	1	30	31
2015	0	41	41
2016	1	37	38
2017	0	41	41
2018	0	22	22
2019	0	29	29
2020	1	15	16
2021	0	28	28
2022	0	3	3
2023	0	4	4
2024	1	12	13
2025	0	3	3

Below are the most recent publications written about "Protein Binding" by people in Profiles.

Golovin AV, Panteleev S, Zlobin AS, Anikeeva N, Smirnov I, Gabibov A, Sykulev Y. The role of peptide conformation presented by MHC in the induction of TCR triggering. Biophys J. 2025 Apr 01; 124(7):1073-1084.

View in: PubMed
Cheng SJ, Gafaar T, Kuttiyatveetil JRA, Sverzhinsky A, Chen C, Xu M, Lilley A, Pascal JM, Leung AKL. Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13. Nat Commun. 2025 Jan 13; 16(1):621.

View in: PubMed
Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

View in: PubMed
Valerie NCK, Sanjiv K, Mortusewicz O, Zhang SM, Alam S, Pires MJ, Stigsdotter H, Rasti A, Langelier MF, Rehling D, Throup A, Purewal-Sidhu O, Desroses M, Onireti J, Wakchaure P, Alml?f I, Bostr?m J, Bevc L, Benzi G, Stenmark P, Pascal JM, Helleday T, Page BDG, Altun M. Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM. Nat Commun. 2024 12 06; 15(1):10347.

View in: PubMed
Imam IA, Al Adawi S, Liu X, Ellingson S, Brainson CF, Moseley HNB, Zinner R, Zhang S, Shao Q. L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds. Proteins. 2025 Mar; 93(3):673-683.

View in: PubMed
Shinkai A, Hashimoto H, Shimura C, Fujimoto H, Fukuda K, Horikoshi N, Okano M, Niwa H, Debler EW, Kurumizaka H, Shinkai Y. The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS. Nucleic Acids Res. 2024 Sep 23; 52(17):10194-10219.

View in: PubMed
Tang J, Becker M, Lenhoff A, Chen W. Engineering of heterobifunctional biopolymers for tunable binding and precipitation of Strep-Tag proteins and virus-like nanoparticles. Biotechnol Bioeng. 2024 Dec; 121(12):3860-3868.

View in: PubMed
Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 09 10; 15(1):7887.

View in: PubMed
Vukovic I, Barnada SM, Ruffin JW, Karlin J, Lokareddy RK, Cingolani G, McMahon SB. Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b. Life Sci Alliance. 2024 Nov; 7(11).

View in: PubMed
Ko YH, Lokareddy RK, Doll SG, Yeggoni DP, Girdhar A, Mawn I, Klim JR, Rizvi NF, Meyers R, Gillilan RE, Guo L, Cingolani G. Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin a1/? Signaling. J Mol Biol. 2024 Oct 15; 436(20):168751.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement