Protein Binding

"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor ID	D011485
MeSH Number(s)	G02.111.679 G03.808
Concept/Terms	Protein Binding Protein Binding Binding, Protein Plasma Protein Binding Capacity Plasma Protein Binding Capacity

Below are MeSH descriptors whose meaning is more general than "Protein Binding".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Protein Binding [G02.111.679]
Metabolism [G03]
Protein Binding [G03.808]

Below are MeSH descriptors whose meaning is related to "Protein Binding".

Below are MeSH descriptors whose meaning is more specific than "Protein Binding".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.

Bar chart showing 590 publications over 31 distinct years, with a maximum of 51 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	3	3
1996	0	2	2
1997	0	5	5
1998	0	1	1
1999	0	9	9
2000	0	10	10
2001	0	12	12
2002	0	47	47
2003	1	50	51
2004	0	39	39
2005	0	43	43
2006	0	38	38
2007	0	36	36
2008	0	40	40
2009	1	42	43
2010	0	34	34
2011	0	37	37
2012	0	28	28
2013	0	14	14
2014	0	11	11
2015	0	15	15
2016	0	11	11
2017	0	21	21
2018	0	8	8
2019	0	4	4
2020	0	2	2
2021	0	11	11
2022	0	3	3
2023	0	3	3
2024	1	7	8
2025	0	1	1

Below are the most recent publications written about "Protein Binding" by people in Profiles.

Kim KM, Girdhar A, Cicardi ME, Kankate V, Hayashi M, Yang R, Carey JL, Fare CM, Shorter J, Cingolani G, Trotti D, Guo L. NLS-binding deficient Kap?2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats. Commun Biol. 2025 Jan 02; 8(1):2.

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Valerie NCK, Sanjiv K, Mortusewicz O, Zhang SM, Alam S, Pires MJ, Stigsdotter H, Rasti A, Langelier MF, Rehling D, Throup A, Purewal-Sidhu O, Desroses M, Onireti J, Wakchaure P, Alml?f I, Bostr?m J, Bevc L, Benzi G, Stenmark P, Pascal JM, Helleday T, Page BDG, Altun M. Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM. Nat Commun. 2024 Dec 06; 15(1):10347.

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Hayashi M, Girdhar A, Ko YH, Kim KM, DePierro JA, Buchler JR, Arunprakash N, Bajaj A, Cingolani G, Guo L. Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS. Nat Commun. 2024 Sep 10; 15(1):7887.

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Vukovic I, Barnada SM, Ruffin JW, Karlin J, Lokareddy RK, Cingolani G, McMahon SB. Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b. Life Sci Alliance. 2024 Nov; 7(11).

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Herbine K, Nayak AR, Temiakov D. Structural basis for substrate binding and selection by human mitochondrial RNA polymerase. Nat Commun. 2024 Aug 20; 15(1):7134.

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Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT. Structural basis for a Pol? helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 Aug 14; 15(1):7003.

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Cocom-Chan B, Khakzad H, Konate M, Aguilar DI, Bello C, Valencia-Gallardo C, Zarrouk Y, Fattaccioli J, Mauviel A, Javelaud D, Tran Van Nhieu G. IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion. Life Sci Alliance. 2024 Aug; 7(8).

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Freidel MR, Armen RS. Research Progress on Spike-Dependent SARS-CoV-2 Fusion Inhibitors and Small Molecules Targeting the S2 Subunit of Spike. Viruses. 2024 04 30; 16(5).

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Freidel MR, Vakhariya PA, Sardarni SK, Armen RS. The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein. Viruses. 2024 04 20; 16(4).

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Mercier R, Yama D, LaPointe P, Johnson JL. Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle. PLoS Genet. 2023 05; 19(5):e1010772.

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