Huntingtin Protein

"Huntingtin Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein that is highly expressed in the nervous system as well as other tissues; its size and structure vary due to polymorphisms. Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES. Huntingtin interacts with proteins involved in a variety of gene expression and cellular processes; it is also essential for embryonic development.

Descriptor ID	D000071058
MeSH Number(s)	D12.776.441
Concept/Terms	Huntingtin Protein Huntingtin Protein IT15 Protein Huntington Disease Protein

Below are MeSH descriptors whose meaning is more general than "Huntingtin Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Huntingtin Protein [D12.776.441]

Below are MeSH descriptors whose meaning is related to "Huntingtin Protein".

Below are MeSH descriptors whose meaning is more specific than "Huntingtin Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Huntingtin Protein" by people in this website by year, and whether "Huntingtin Protein" was a major or minor topic of these publications.

Bar chart showing 16 publications over 12 distinct years, with a maximum of 2 publications in 2001 and 2004 and 2006 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	2	2
2002	0	1	1
2003	0	1	1
2004	0	2	2
2005	0	1	1
2006	0	2	2
2007	0	1	1
2008	0	1	1
2011	0	2	2
2014	0	1	1
2015	0	1	1
2018	1	0	1

Below are the most recent publications written about "Huntingtin Protein" by people in Profiles.

Oh E, Liu Y, Sonar MV, Merry DE, Wickstrom E. Fluorescence Imaging of Huntingtin mRNA Knockdown. Bioconjug Chem. 2018 04 18; 29(4):1276-1282.

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Morozova OA, Gupta S, Colby DW. Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation. FEBS Lett. 2015 Jul 08; 589(15):1897-903.

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Barbaro BA, Lukacsovich T, Agrawal N, Burke J, Bornemann DJ, Purcell JM, Worthge SA, Caricasole A, Weiss A, Song W, Morozova OA, Colby DW, Marsh JL. Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease. Hum Mol Genet. 2015 Feb 15; 24(4):913-25.

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Tong Y, Ha TJ, Liu L, Nishimoto A, Reiner A, Goldowitz D. Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development. J Neurosci. 2011 Oct 12; 31(41):14794-9.

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Schiefner A, Chatwell L, K?rner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol. 2011 Dec 02; 414(3):337-55.

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Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A. CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse. Neurobiol Dis. 2009 Mar; 33(3):315-30.

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Reiner A, Del Mar N, Deng YP, Meade CA, Sun Z, Goldowitz D. R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice. J Comp Neurol. 2007 Dec 20; 505(6):603-29.

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Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation. EMBO J. 2006 Dec 13; 25(24):5896-906.

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Colby DW, Cassady JP, Lin GC, Ingram VM, Wittrup KD. Stochastic kinetics of intracellular huntingtin aggregate formation. Nat Chem Biol. 2006 Jun; 2(6):319-23.

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Sun Z, Wang HB, Deng YP, Lei WL, Xie JP, Meade CA, Del Mar N, Goldowitz D, Reiner A. Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice. Neurobiol Dis. 2005 Dec; 20(3):907-17.

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