"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
|
| MeSH Number(s) |
E05.393.420.601
|
| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
|
Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 3 | 1 | 4 |
| 2004 | 2 | 1 | 3 |
| 2005 | 5 | 2 | 7 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 3 | 2 | 5 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Young CL, Britton ZT, Robinson AS. Recombinant protein expression and purification: a comprehensive review of affinity tags and microbial applications. Biotechnol J. 2012 May; 7(5):620-34.
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Sacco E, Metalli D, Spinelli M, Manzoni R, Samalikova M, Grandori R, Morrione A, Traversa S, Alberghina L, Vanoni M. Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells. Biotechnol Adv. 2012 Jan-Feb; 30(1):233-43.
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Top A, Roberts CJ, Kiick KL. Conformational and aggregation properties of a PEGylated alanine-rich polypeptide. Biomacromolecules. 2011 Jun 13; 12(6):2184-92.
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De Zoysa Ariyananda L, Antonopoulos C, Currier J, Colman RF. In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes. Biochemistry. 2011 Mar 1; 50(8):1336-46.
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Nagarkar RP, Hule RA, Pochan DJ, Schneider JP. Domain swapping in materials design. Biopolymers. 2010; 94(1):141-55.
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Kaushal G, Shao J. Genetically engineered normal flora for oral polypeptide delivery: dose-absorption response. J Pharm Sci. 2009 Aug; 98(8):2573-80.
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Kandavelou K, Ramalingam S, London V, Mani M, Wu J, Alexeev V, Civin CI, Chandrasegaran S. Targeted manipulation of mammalian genomes using designed zinc finger nucleases. Biochem Biophys Res Commun. 2009 Oct 9; 388(1):56-61.
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Gupta P, Lee KH. Silent mutations result in HlyA hypersecretion by reducing intracellular HlyA protein aggregates. Biotechnol Bioeng. 2008 Dec 1; 101(5):967-74.
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Papoutsakis ET. Engineering solventogenic clostridia. Curr Opin Biotechnol. 2008 Oct; 19(5):420-9.
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Sillers R, Chow A, Tracy B, Papoutsakis ET. Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance. Metab Eng. 2008 Nov; 10(6):321-32.