DNA Restriction-Modification Enzymes
"DNA Restriction-Modification Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
| Descriptor ID |
D015280
|
| MeSH Number(s) |
D08.811.150
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| Concept/Terms |
DNA Restriction-Modification Enzymes- DNA Restriction-Modification Enzymes
- Enzymes, DNA Restriction-Modification
- Restriction-Modification Enzymes, DNA
- Restriction-Modification Systems
- Systems, Restriction-Modification
- Restriction Modification Systems
- Modification Systems, Restriction
- Systems, Restriction Modification
- DNA Restriction Modification Enzymes
|
Below are MeSH descriptors whose meaning is more general than "DNA Restriction-Modification Enzymes".
Below are MeSH descriptors whose meaning is more specific than "DNA Restriction-Modification Enzymes".
This graph shows the total number of publications written about "DNA Restriction-Modification Enzymes" by people in this website by year, and whether "DNA Restriction-Modification Enzymes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Restriction-Modification Enzymes" by people in Profiles.
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Lee JH, Karamychev VN, Kozyavkin SA, Mills D, Pavlov AR, Pavlova NV, Polouchine NN, Richardson PM, Shakhova VV, Slesarev AI, Weimer B, O'Sullivan DJ. Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics. 2008 May 27; 9:247.
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Yang JM, Deurraza PJ, Matvienko N, O'Sullivan DJ. Involvement of the LlaKR2I methylase in expression of the AbiR bacteriophage defense system in Lactococcus lactis subsp. lactis biovar diacetylactis KR2. J Bacteriol. 2006 Mar; 188(5):1920-8.
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Twomey DP, De Urraza PJ, McKay LL, O'Sullivan DJ. Characterization of AbiR, a novel multicomponent abortive infection mechanism encoded by plasmid pKR223 of Lactococcus lactis subsp. lactis KR2. Appl Environ Microbiol. 2000 Jun; 66(6):2647-51.
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Djordjevic GM, O'Sullivan DJ, Walker SA, Conkling MA, Klaenhammer TR. A triggered-suicide system designed as a defense against bacteriophages. J Bacteriol. 1997 Nov; 179(21):6741-8.
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O'Sullivan DJ, Klaenhammer TR. C.LlaI is a bifunctional regulatory protein of the llaI restriction modification operon from Lactococcus lactis. Dev Biol Stand. 1995; 85:591-5.
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O'Sullivan DJ, Zagula K, Klaenhammer TR. In vivo restriction by LlaI is encoded by three genes, arranged in an operon with llaIM, on the conjugative Lactococcus plasmid pTR2030. J Bacteriol. 1995 Jan; 177(1):134-43.