"Transducin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
| Descriptor ID |
D015293
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.800 D12.644.360.360.940 D12.776.157.325.332.940 D12.776.476.375.940 D12.776.543.325.800
|
| Concept/Terms |
Transducin- Transducin
- Transducin G-Protein (Gt)
- Gt, Transducin G-Protein
- G-Protein Gt, Transducin
- Gt, Transducin G Protein
- Transducin G-Protein Gt
- G-Protein, Inhibitory Gt
- G Protein, Inhibitory Gt
- Gt G-Protein, Inhibitory
- Inhibitory Gt G-Protein
gamma-Transducin- gamma-Transducin
- gamma Transducin
- Transducin, gamma Subunit
- gamma Subunit Transducin
beta-Transducin- beta-Transducin
- beta Transducin
- Transducin, beta Subunit
- beta Subunit Transducin
alpha-Transducin- alpha-Transducin
- alpha Transducin
- Transducin, alpha Subunit
- alpha Subunit Transducin
|
Below are MeSH descriptors whose meaning is more general than "Transducin".
Below are MeSH descriptors whose meaning is more specific than "Transducin".
This graph shows the total number of publications written about "Transducin" by people in this website by year, and whether "Transducin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transducin" by people in Profiles.
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Komolov KE, Koch KW. Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signalling. Methods Mol Biol. 2010; 627:249-60.
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Krupnick JG, Gurevich VV, Benovic JL. Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. J Biol Chem. 1997 Jul 18; 272(29):18125-31.
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Richardson RM, Kim C, Benovic JL, Hosey MM. Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase. J Biol Chem. 1993 Jun 25; 268(18):13650-6.
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Krupinski J, Rajaram R, Lakonishok M, Benovic JL, Cerione RA. Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem. 1988 Sep 05; 263(25):12333-41.
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Cerione RA, Gierschik P, Staniszewski C, Benovic JL, Codina J, Somers R, Birnbaumer L, Spiegel AM, Lefkowitz RJ, Caron MG. Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 1987 Mar 10; 26(5):1485-91.
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Cerione RA, Regan JW, Nakata H, Codina J, Benovic JL, Gierschik P, Somers RL, Spiegel AM, Birnbaumer L, Lefkowitz RJ, et al. Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem. 1986 Mar 15; 261(8):3901-9.
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Cerione RA, Staniszewski C, Benovic JL, Lefkowitz RJ, Caron MG, Gierschik P, Somers R, Spiegel AM, Codina J, Birnbaumer L. Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J Biol Chem. 1985 Feb 10; 260(3):1493-500.