Inositol 1,4,5-Trisphosphate
"Inositol 1,4,5-Trisphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
| Descriptor ID |
D015544
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| MeSH Number(s) |
D02.033.800.519.400.350 D09.853.519.400.350 D09.894.480.350
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate- Inositol 1,4,5-Trisphosphate
- Inositol 1,4,5-Triphosphate
- Myoinositol 1,4,5-Triphosphate
- 1,4,5-InsP3
- 1,4,5-IP3
- Myo-Inositol 1,4,5-Trisphosphate
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate".
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 3 | 4 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate" by people in Profiles.
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Arige V, Terry LE, Wagner LE, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI. Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2209267119.
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Gaspers LD, Bartlett PJ, Politi A, Burnett P, Metzger W, Johnston J, Joseph SK, H?fer T, Thomas AP. Hormone-induced calcium oscillations depend on cross-coupling with inositol 1,4,5-trisphosphate oscillations. Cell Rep. 2014 Nov 20; 9(4):1209-18.
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Brailoiu E, Deliu E, Sporici RA, Benamar K, Brailoiu GC. HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 01; 306(11):R814-22.
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B?ns?ghi S, Golen?r T, Madesh M, Csord?s G, RamachandraRao S, Sharma K, Yule DI, Joseph SK, Hajn?czky G. Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem. 2014 Mar 21; 289(12):8170-81.
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Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E. Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C736-44.
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Wagner LE, Joseph SK, Yule DI. Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation. J Physiol. 2008 Aug 01; 586(15):3577-96.
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Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang JK, Dun NJ. Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium. Endocrinology. 2006 Jul; 147(7):3243-8.
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Joseph SK, Brownell S, Khan MT. Calcium regulation of inositol 1,4,5-trisphosphate receptors. Cell Calcium. 2005 Dec; 38(6):539-46.
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McGowan TA, Madesh M, Zhu Y, Wang L, Russo M, Deelman L, Henning R, Joseph S, Hajnoczky G, Sharma K. TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton. Am J Physiol Renal Physiol. 2002 May; 282(5):F910-20.
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Okada H, Bolland S, Hashimoto A, Kurosaki M, Kabuyama Y, Iino M, Ravetch JV, Kurosaki T. Role of the inositol phosphatase SHIP in B cell receptor-induced Ca2+ oscillatory response. J Immunol. 1998 Nov 15; 161(10):5129-32.