Transforming Growth Factor alpha
"Transforming Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
| Descriptor ID |
D016211
|
| MeSH Number(s) |
D12.644.276.382.750 D12.644.276.963.360 D12.776.467.382.750 D12.776.467.960.360 D23.529.382.750 D23.529.960.360
|
| Concept/Terms |
Transforming Growth Factor alpha- Transforming Growth Factor alpha
- TGF-alpha
- TGFalpha
- Epidermal Growth Factor-Related Transforming Growth Factor
- Epidermal Growth Factor Related Transforming Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor alpha".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor alpha".
This graph shows the total number of publications written about "Transforming Growth Factor alpha" by people in this website by year, and whether "Transforming Growth Factor alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 |
| 1993 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor alpha" by people in Profiles.
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Moskowitz HS, Gooding WE, Thomas SM, Freilino ML, Gross N, Argiris A, Grandis JR, Ferris RL. Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer. Oral Oncol. 2012 Nov; 48(11):1136-45.
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Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis JR, Egloff AM. Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies. Invest New Drugs. 2012 Aug; 30(4):1575-84.
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Hao H, Schwaber J. Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus. Brain Res. 2006 May 9; 1088(1):45-8.
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Goncharova EA, Billington CK, Irani C, Vorotnikov AV, Tkachuk VA, Penn RB, Krymskaya VP, Panettieri RA. Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):19-27.
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Vardy DA, Kari C, Lazarus GS, Jensen PJ, Zilberstein A, Plowman GD, Rodeck U. Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. J Cell Physiol. 1995 May; 163(2):257-65.
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Schmiegel W, Roeder C, Schmielau J, Rodeck U, Kalthoff H. Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. Proc Natl Acad Sci U S A. 1993 Feb 1; 90(3):863-7.
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Valyi-Nagy I, Jensen PJ, Albelda SM, Rodeck U. Cytokine-induced expression of transforming growth factor-alpha and the epidermal growth factor receptor in neonatal skin explants. J Invest Dermatol. 1992 Sep; 99(3):350-6.
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Murthy U, Rieman DJ, Rodeck U. Inhibition of TGF alpha-induced second messengers by anti-EGF receptor antibody-425. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):471-6.
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Rodeck U, Williams N, Murthy U, Herlyn M. Monoclonal antibody 425 inhibits growth stimulation of carcinoma cells by exogenous EGF and tumor-derived EGF/TGF-alpha. J Cell Biochem. 1990 Oct; 44(2):69-79.