"PC12 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
| Descriptor ID |
D016716
|
| MeSH Number(s) |
A11.251.210.190.750 A11.251.860.180.750 A11.299.500
|
| Concept/Terms |
PC12 Cells- PC12 Cells
- PC12 Cell
- Pheochromocytoma Cell Line
- Cell Line, Pheochromocytoma
- Cell Lines, Pheochromocytoma
- Pheochromocytoma Cell Lines
|
Below are MeSH descriptors whose meaning is more general than "PC12 Cells".
Below are MeSH descriptors whose meaning is more specific than "PC12 Cells".
This graph shows the total number of publications written about "PC12 Cells" by people in this website by year, and whether "PC12 Cells" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 5 | 5 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "PC12 Cells" by people in Profiles.
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Karliner J, Liu Y, Merry DE. Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA. Proc Natl Acad Sci U S A. 2024 07 16; 121(29):e2321408121.
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Karliner J, Merry DE. Differentiating PC12 cells to evaluate neurite densities through live-cell imaging. STAR Protoc. 2023 03 17; 4(1):101993.
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Pluciennik A, Liu Y, Molotsky E, Marsh GB, Ranxhi B, Arnold FJ, St-Cyr S, Davidson B, Pourshafie N, Lieberman AP, Gu W, Todi SV, Merry DE. Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy. J Clin Invest. 2021 01 04; 131(1).
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Arnold FJ, Pluciennik A, Merry DE. Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. Sci Rep. 2019 01 15; 9(1):119.
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Cristofani R, Crippa V, Rusmini P, Cicardi ME, Meroni M, Licata NV, Sala G, Giorgetti E, Grunseich C, Galbiati M, Piccolella M, Messi E, Ferrarese C, Carra S, Poletti A. Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases. Autophagy. 2017 Aug 03; 13(8):1280-1303.
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Bott LC, Salomons FA, Maric D, Liu Y, Merry D, Fischbeck KH, Dantuma NP. The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex. Sci Rep. 2016 06 17; 6:27703.
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Berger TR, Montie HL, Jain P, Legleiter J, Merry DE. Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy. Brain Res. 2015 Dec 02; 1628(Pt B):254-264.
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Lindsey S, Piatt JH, Worthington P, S?nmez C, Satheye S, Schneider JP, Pochan DJ, Langhans SA. Beta Hairpin Peptide Hydrogels as an Injectable Solid Vehicle for Neurotrophic Growth Factor Delivery. Biomacromolecules. 2015 Sep 14; 16(9):2672-83.
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Heine EM, Berger TR, Pluciennik A, Orr CR, Zboray L, Merry DE. Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis. J Biol Chem. 2015 May 15; 290(20):12572-84.
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Carriba P, Jimenez S, Navarro V, Moreno-Gonzalez I, Barneda-Zahonero B, Moubarak RS, Lopez-Soriano J, Gutierrez A, Vitorica J, Comella JX. Amyloid-? reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFa from neuronal protection to death. Cell Death Dis. 2015 Feb 12; 6:e1639.