Cyclooxygenase Inhibitors

"Cyclooxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Descriptor ID	D016861
MeSH Number(s)	D27.505.519.389.310 D27.505.696.663.850.014.040.500.500 D27.505.954.158.030.500 D27.505.954.329.030.500
Concept/Terms	Cyclooxygenase Inhibitors Cyclooxygenase Inhibitors Inhibitors, Cyclo-Oxygenase Inhibitors, Cyclo Oxygenase Inhibitors, Cyclooxygenase Prostaglandin Synthesis Antagonists Antagonists, Prostaglandin Synthesis Inhibitors, Prostaglandin-Endoperoxide Synthase Inhibitors, Prostaglandin Endoperoxide Synthase Prostaglandin Endoperoxide Synthase Inhibitors Prostaglandin Synthase Inhibitors Cyclo-Oxygenase Inhibitors Cyclo Oxygenase Inhibitors Inhibitors, Prostaglandin Synthase

Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Cyclooxygenase Inhibitors [D27.505.519.389.310]
Physiological Effects of Drugs [D27.505.696]
Peripheral Nervous System Agents [D27.505.696.663]
Sensory System Agents [D27.505.696.663.850]
Analgesics [D27.505.696.663.850.014]
Analgesics, Non-Narcotic [D27.505.696.663.850.014.040]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.696.663.850.014.040.500]
Cyclooxygenase Inhibitors [D27.505.696.663.850.014.040.500.500]
Therapeutic Uses [D27.505.954]
Anti-Inflammatory Agents [D27.505.954.158]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.158.030]
Cyclooxygenase Inhibitors [D27.505.954.158.030.500]
Antirheumatic Agents [D27.505.954.329]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.329.030]
Cyclooxygenase Inhibitors [D27.505.954.329.030.500]

Below are MeSH descriptors whose meaning is related to "Cyclooxygenase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase Inhibitors".

Cyclooxygenase Inhibitors
Cyclooxygenase 2 Inhibitors

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclooxygenase Inhibitors" by people in this website by year, and whether "Cyclooxygenase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 76 publications over 21 distinct years, with a maximum of 11 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	1	3
1997	1	0	1
2000	2	0	2
2001	2	0	2
2002	2	1	3
2003	5	6	11
2004	4	0	4
2005	3	5	8
2006	4	2	6
2007	4	3	7
2008	1	3	4
2009	0	2	2
2012	1	2	3
2013	1	1	2
2014	1	1	2
2015	1	1	2
2016	1	2	3
2017	2	0	2
2018	3	1	4
2019	0	2	2
2021	2	1	3

Below are the most recent publications written about "Cyclooxygenase Inhibitors" by people in Profiles.

Friedrich L, Cingolani G, Ko YH, Iaselli M, Miciaccia M, Perrone MG, Neukirch K, Bobinger V, Merk D, Hofstetter RK, Werz O, Koeberle A, Scilimati A, Schneider G. Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. Adv Sci (Weinh). 2021 08; 8(16):e2100832.

View in: PubMed
Jones Lipinski RA, Thillier Y, Morisseau C, Sebastiano CS, Smith BC, Hall CD, Katritzky AR. Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity. Chem Biol Drug Des. 2021 07; 98(1):102-113.

View in: PubMed
Miciaccia M, Belviso BD, Iaselli M, Cingolani G, Ferorelli S, Cappellari M, Loguercio Polosa P, Perrone MG, Caliandro R, Scilimati A. Three-dimensional structure of human cyclooxygenase (hCOX)-1. Sci Rep. 2021 02 22; 11(1):4312.

View in: PubMed
Patel SS, Ludmir J. Drugs for the Treatment and Prevention of Preterm Labor. Clin Perinatol. 2019 06; 46(2):159-172.

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Nagalla S, Sarode R. Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy. Transfus Med Rev. 2019 04; 33(2):92-97.

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Logsdon AF, Meabon JS, Cline MM, Bullock KM, Raskind MA, Peskind ER, Banks WA, Cook DG. Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes. Sci Rep. 2018 07 27; 8(1):11344.

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Williams AD, Li YR, So A, Steel L, Carrigan E, Ro V, Nguyen J, Tchou J. The impact of aspirin use on breast cancer subtype and clinical course. J Surg Res. 2018 10; 230:71-79.

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Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1632-1643.

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Jin X, Zimmers TA, Jiang Y, Milgrom DP, Zhang Z, Koniaris LG. Meloxicam increases epidermal growth factor receptor expression improving survival after hepatic resection in diet-induced obese mice. Surgery. 2018 06; 163(6):1264-1271.

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Teerlink JR, Qian M, Bello NA, Freudenberger RS, Levin B, Di Tullio MR, Graham S, Mann DL, Sacco RL, Mohr JP, Lip GYH, Labovitz AJ, Lee SC, Ponikowski P, Lok DJ, Anker SD, Thompson JLP, Homma S. Aspirin Does Not Increase Heart Failure?Events in Heart Failure Patients: From the WARCEF?Trial. JACC Heart Fail. 2017 08; 5(8):603-610.

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