Cyclooxygenase Inhibitors

"Cyclooxygenase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Descriptor ID	D016861
MeSH Number(s)	D27.505.519.389.310 D27.505.696.663.850.014.040.500.500 D27.505.954.158.030.500 D27.505.954.329.030.500
Concept/Terms	Cyclooxygenase Inhibitors Cyclooxygenase Inhibitors Inhibitors, Cyclo-Oxygenase Inhibitors, Cyclo Oxygenase Inhibitors, Cyclooxygenase Prostaglandin Synthesis Antagonists Antagonists, Prostaglandin Synthesis Inhibitors, Prostaglandin-Endoperoxide Synthase Inhibitors, Prostaglandin Endoperoxide Synthase Prostaglandin Endoperoxide Synthase Inhibitors Prostaglandin Synthase Inhibitors Cyclo-Oxygenase Inhibitors Cyclo Oxygenase Inhibitors Inhibitors, Prostaglandin Synthase

Below are MeSH descriptors whose meaning is more general than "Cyclooxygenase Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Cyclooxygenase Inhibitors [D27.505.519.389.310]
Physiological Effects of Drugs [D27.505.696]
Peripheral Nervous System Agents [D27.505.696.663]
Sensory System Agents [D27.505.696.663.850]
Analgesics [D27.505.696.663.850.014]
Analgesics, Non-Narcotic [D27.505.696.663.850.014.040]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.696.663.850.014.040.500]
Cyclooxygenase Inhibitors [D27.505.696.663.850.014.040.500.500]
Therapeutic Uses [D27.505.954]
Anti-Inflammatory Agents [D27.505.954.158]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.158.030]
Cyclooxygenase Inhibitors [D27.505.954.158.030.500]
Antirheumatic Agents [D27.505.954.329]
Anti-Inflammatory Agents, Non-Steroidal [D27.505.954.329.030]
Cyclooxygenase Inhibitors [D27.505.954.329.030.500]

Below are MeSH descriptors whose meaning is related to "Cyclooxygenase Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Cyclooxygenase Inhibitors".

Cyclooxygenase Inhibitors
Cyclooxygenase 2 Inhibitors

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclooxygenase Inhibitors" by people in this website by year, and whether "Cyclooxygenase Inhibitors" was a major or minor topic of these publications.

Bar chart showing 46 publications over 13 distinct years, with a maximum of 10 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	5	5	10
2004	3	0	3
2005	3	4	7
2006	4	2	6
2007	4	1	5
2008	1	3	4
2009	0	2	2
2012	1	1	2
2013	0	1	1
2015	1	0	1
2017	1	0	1
2018	1	1	2

Below are the most recent publications written about "Cyclooxygenase Inhibitors" by people in Profiles.

Logsdon AF, Meabon JS, Cline MM, Bullock KM, Raskind MA, Peskind ER, Banks WA, Cook DG. Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes. Sci Rep. 2018 07 27; 8(1):11344.

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Williams AD, Li YR, So A, Steel L, Carrigan E, Ro V, Nguyen J, Tchou J. The impact of aspirin use on breast cancer subtype and clinical course. J Surg Res. 2018 10; 230:71-79.

View in: PubMed
Teerlink JR, Qian M, Bello NA, Freudenberger RS, Levin B, Di Tullio MR, Graham S, Mann DL, Sacco RL, Mohr JP, Lip GYH, Labovitz AJ, Lee SC, Ponikowski P, Lok DJ, Anker SD, Thompson JLP, Homma S. Aspirin Does Not Increase Heart Failure?Events in Heart Failure Patients: From the WARCEF?Trial. JACC Heart Fail. 2017 08; 5(8):603-610.

View in: PubMed
Schiffler MA, Antonysamy S, Bhattachar SN, Campanale KM, Chandrasekhar S, Condon B, Desai PV, Fisher MJ, Groshong C, Harvey A, Hickey MJ, Hughes NE, Jones SA, Kim EJ, Kuklish SL, Luz JG, Norman BH, Rathmell RE, Rizzo JR, Seng TW, Thibodeaux SJ, Woods TA, York JS, Yu XP. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J Med Chem. 2016 Jan 14; 59(1):194-205.

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Kuriyan AE, Woeller CF, O'Loughlin CW, Phipps RP, Feldon SE. Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. Invest Ophthalmol Vis Sci. 2013 Nov 08; 54(12):7370-7.

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Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, Mutawe MM, Mitchell RW, Halayko AJ. Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. Br J Pharmacol. 2012 Oct; 167(3):548-60.

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Adrouche-Amrani L, Green RS, Gluck KM, Lin J. Failure of a repeat course of cyclooxygenase inhibitor to close a PDA is a risk factor for developing chronic lung disease in ELBW infants. BMC Pediatr. 2012 Jan 27; 12:10.

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Weidhaas JB, Li SX, Winter K, Ryu J, Jhingran A, Miller B, Dicker AP, Gaffney D. Changes in gene expression predicting local control in cervical cancer: results from Radiation Therapy Oncology Group 0128. Clin Cancer Res. 2009 Jun 15; 15(12):4199-206.

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de Godoy MA, Rattan N, Rattan S. Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G727-34.

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de Godoy MA, Rattan N, Rattan S. COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G219-25.

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