"Prion Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)
Descriptor ID |
D017096
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MeSH Number(s) |
C10.228.228.800 C10.574.843
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Concept/Terms |
Prion Diseases- Prion Diseases
- Spongiform Encephalopathies, Transmissible
- Encephalopathies, Transmissible Spongiform
- Encephalopathy, Transmissible Spongiform
- Spongiform Encephalopathy, Transmissible
- Transmissible Spongiform Encephalopathy
- Dementias, Transmissible
- Dementia, Transmissible
- Transmissible Dementia
- Transmissible Dementias
- Prion-Induced Disorders
- Prion Protein Diseases
- Prion Protein Disease
- Prion-Induced Disorder
- Disorder, Prion-Induced
- Disorders, Prion-Induced
- Prion Induced Disorder
- Prion Disease
- Prion-Associated Disorders
- Transmissible Spongiform Encephalopathies
- Encephalopathies, Spongiform, Transmissible
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Below are MeSH descriptors whose meaning is more general than "Prion Diseases".
Below are MeSH descriptors whose meaning is more specific than "Prion Diseases".
This graph shows the total number of publications written about "Prion Diseases" by people in this website by year, and whether "Prion Diseases" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
2004 | 1 | 0 | 1 |
2008 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
2011 | 2 | 1 | 3 |
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Below are the most recent publications written about "Prion Diseases" by people in Profiles.
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Gupta S, Jie S, Colby DW. Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay. J Biol Chem. 2012 Mar 23; 287(13):9982-9.
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Kumar N, Boeve BF, Boot BP, Orr CF, Duffy J, Woodruff BK, Nair AK, Ellison J, Kuntz K, Kantarci K, Jack CR, Westmoreland BF, Fields JA, Baker M, Rademakers R, Parisi JE, Dickson DW. Clinical characterization of a kindred with a novel 12-octapeptide repeat insertion in the prion protein gene. Arch Neurol. 2011 Sep; 68(9):1165-70.
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Colby DW, Prusiner SB. Prions. Cold Spring Harb Perspect Biol. 2011 Jan; 3(1):a006833.
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Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB. Protease-sensitive synthetic prions. PLoS Pathog. 2010 Jan; 6(1):e1000736.
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Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB. Design and construction of diverse mammalian prion strains. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20417-22.
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Wu-Chen WY, Moster ML. The 60th annual meeting of the American Academy of Neurology Chicago, Illinois, April 12-19, 2008. J Neuroophthalmol. 2008 Dec; 28(4):352-7.
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Nee LE, Tierney MC, Lippa CF. Genetic aspects of Alzheimer's disease, Pick's disease, and other dementias. Am J Alzheimers Dis Other Demen. 2004 Jul-Aug; 19(4):219-25.
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Mastrianni JA, Curtis MT, Oberholtzer JC, Da Costa MM, DeArmond S, Prusiner SB, Garbern JY. Prion disease (PrP-A117V) presenting with ataxia instead of dementia. Neurology. 1995 Nov; 45(11):2042-50.