Apoptosis

"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Descriptor ID	D017209
MeSH Number(s)	G04.146.160
Concept/Terms	Apoptosis Apoptosis Programmed Cell Death, Type I Apoptosis, Intrinsic Pathway Apoptosis, Intrinsic Pathway Apoptoses, Intrinsic Pathway Intrinsic Pathway Apoptoses Intrinsic Pathway Apoptosis Apoptosis, Extrinsic Pathway Apoptosis, Extrinsic Pathway Apoptoses, Extrinsic Pathway Extrinsic Pathway Apoptoses Extrinsic Pathway Apoptosis

Below are MeSH descriptors whose meaning is more general than "Apoptosis".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Apoptosis [G04.146.160]

Below are MeSH descriptors whose meaning is related to "Apoptosis".

Below are MeSH descriptors whose meaning is more specific than "Apoptosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.

Bar chart showing 598 publications over 30 distinct years, with a maximum of 39 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	5	2	7
1997	9	2	11
1998	5	3	8
1999	16	13	29
2000	8	10	18
2001	18	9	27
2002	12	13	25
2003	10	18	28
2004	11	16	27
2005	10	21	31
2006	14	17	31
2007	17	22	39
2008	19	19	38
2009	16	15	31
2010	8	18	26
2011	10	26	36
2012	5	18	23
2013	2	21	23
2014	2	11	13
2015	4	20	24
2016	4	15	19
2017	1	17	18
2018	5	6	11
2019	2	17	19
2020	1	12	13
2021	1	7	8
2022	0	2	2
2023	1	5	6
2024	2	4	6
2025	1	0	1

Below are the most recent publications written about "Apoptosis" by people in Profiles.

Islam R, Roche ME, Lin Z, Whitaker-Menezes D, Diaz-Barros V, Serrano E, Martinez Cantarin MP, Philp NJ, Basu Mallick A, Martinez-Outschoorn U. TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis. Mol Oncol. 2025 Aug; 19(8):2431-2455.

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Gan L, Zhao J, Yao P, Christopher TA, Lopez B, Lau WB, Koch W, Gao E, Ma X, Wang Y. Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis. Redox Biol. 2025 02; 79:103443.

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Mondal A, Das B, Karmakar S, Pani S, Khan S, Gupta P, Das Sarma J. Modulatory Role of Pantropic Cell Signaling Pathways in the Antimigratory and Antiproliferative Action of Triazole Chelated Iridium(III) Complexes in Cervical Cancer Cells. J Med Chem. 2024 11 28; 67(22):20559-20570.

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Lerchenm?ller C, Hastings MH, Rabolli CP, Betge F, Roshan M, Liu LX, Liu X, He? C, Roh JD, Platt C, Bezzerides V, Busch M, Katus HA, Frey N, Most P, Rosenzweig A. CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Mol Ther. 2024 10 02; 32(10):3683-3694.

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Nie DY, Tabor JR, Li J, Kutera M, St-Germain J, Hanley RP, Wolf E, Paulakonis E, Kenney TMG, Duan S, Shrestha S, Owens DDG, Maitland MER, Pon A, Szewczyk M, Lamberto AJ, Menes M, Li F, Penn LZ, Barsyte-Lovejoy D, Brown NG, Barsotti AM, Stamford AW, Collins JL, Wilson DJ, Raught B, Licht JD, James LI, Arrowsmith CH. Recruitment of FBXO22 for targeted degradation of NSD2. Nat Chem Biol. 2024 Dec; 20(12):1597-1607.

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Dos Santos DZ, Elbaz M, Branchard E, Schormann W, Brown CE, Meek AR, Njar VCO, Hamilton RJ, Reed MA, Andrews DW, Penn LZ. Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation. Biomed Pharmacother. 2024 Aug; 177:116934.

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Desai V, Tadinada SM, Shaghaghi H, Summer R, Lai JCK, Bhushan A. Combination Treatment of Biochanin A and Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism and Inducing Cell Cycle Arrest in Pancreatic Cancer Cells. Anticancer Res. 2024 Jun; 44(6):2307-2323.

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Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber KJ, Herold-Mende C, van Wijk SJL, Marschalek R, Schaefer L, M?nch C, K?gel D. The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells. Am J Physiol Cell Physiol. 2023 12 01; 325(6):C1451-C1469.

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Cao M, Carlson RD, Staudt RE, Snook AE. In vitro assays to evaluate CAR-T cell cytotoxicity. Methods Cell Biol. 2024; 183:303-315.

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Roche ME, Ko YH, Domingo-Vidal M, Lin Z, Whitaker-Menezes D, Birbe RC, Tuluc M, Gyorffy B, Caro J, Philp NJ, Bartrons R, Martinez-Outschoorn U. TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer. Int J Cancer. 2023 11 01; 153(9):1671-1683.

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