Apoptosis

"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Descriptor ID	D017209
MeSH Number(s)	G04.146.160
Concept/Terms	Apoptosis Apoptosis Programmed Cell Death, Type I Apoptosis, Intrinsic Pathway Apoptosis, Intrinsic Pathway Apoptoses, Intrinsic Pathway Intrinsic Pathway Apoptoses Intrinsic Pathway Apoptosis Apoptosis, Extrinsic Pathway Apoptosis, Extrinsic Pathway Apoptoses, Extrinsic Pathway Extrinsic Pathway Apoptoses Extrinsic Pathway Apoptosis

Below are MeSH descriptors whose meaning is more general than "Apoptosis".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Apoptosis [G04.146.160]

Below are MeSH descriptors whose meaning is related to "Apoptosis".

Below are MeSH descriptors whose meaning is more specific than "Apoptosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.

Bar chart showing 530 publications over 28 distinct years, with a maximum of 50 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1995	3	0	3
1996	11	1	12
1997	15	0	15
1998	8	8	16
1999	11	4	15
2000	5	5	10
2001	13	9	22
2002	21	19	40
2003	17	33	50
2004	13	20	33
2005	13	24	37
2006	12	18	30
2007	27	17	44
2008	18	19	37
2009	15	23	38
2010	11	21	32
2011	9	21	30
2012	6	12	18
2013	1	8	9
2014	0	9	9
2015	1	8	9
2016	1	5	6
2017	0	7	7
2018	1	0	1
2019	0	3	3
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Apoptosis" by people in Profiles.

Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nat Commun. 2021 01 20; 12(1):484.

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Roche ME, Lin Z, Whitaker-Menezes D, Zhan T, Szuhai K, Bovee JVMG, Abraham JA, Jiang W, Martinez-Outschoorn U, Basu-Mallick A. Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Biochim Biophys Acta Mol Basis Dis. 2020 12 01; 1866(12):165962.

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Emami A, Shojaei S, da Silva Rosa SC, Aghaei M, Samiei E, Vosoughi AR, Kalantari F, Kawalec P, Thliveris J, Sharma P, Zeki AA, Akbari M, Gordon JW, Ghavami S. Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition. Eur J Pharmacol. 2019 Nov 05; 862:172616.

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Desai V, Jain A, Shaghaghi H, Summer R, Lai JCK, Bhushan A. Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme. Anticancer Res. 2019 Jan; 39(1):57-66.

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Kolpakov MA, Sikder K, Sarkar A, Chaki S, Shukla SK, Guo X, Qi Z, Barbery C, Sabri A, Rafiq K. Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy. Cell Physiol Biochem. 2019; 53(6):982-998.

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Zhu J, Jin M, Wang J, Zhang H, Wu Y, Li D, Ji X, Yang H, Yin C, Ren T, Xing J. TNFa induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2018 Mar 05; 37(1):43.

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Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J. MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation. Antioxid Redox Signal. 2018 04 20; 28(12):1120-1136.

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Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Semin Oncol. 2017 06; 44(3):226-232.

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Yan W, Guo Y, Tao L, Lau WB, Gan L, Yan Z, Guo R, Gao E, Wong GW, Koch WL, Wang Y, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation. 2017 Nov 28; 136(22):2162-2177.

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Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep 15; 77(18):5095-5106.

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