Apoptosis

"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Descriptor ID	D017209
MeSH Number(s)	G04.146.160
Concept/Terms	Apoptosis Apoptosis Programmed Cell Death, Type I Apoptosis, Intrinsic Pathway Apoptosis, Intrinsic Pathway Apoptoses, Intrinsic Pathway Intrinsic Pathway Apoptoses Intrinsic Pathway Apoptosis Apoptosis, Extrinsic Pathway Apoptosis, Extrinsic Pathway Apoptoses, Extrinsic Pathway Extrinsic Pathway Apoptoses Extrinsic Pathway Apoptosis

Below are MeSH descriptors whose meaning is more general than "Apoptosis".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Apoptosis [G04.146.160]

Below are MeSH descriptors whose meaning is related to "Apoptosis".

Below are MeSH descriptors whose meaning is more specific than "Apoptosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.

Bar chart showing 699 publications over 29 distinct years, with a maximum of 60 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1995	3	0	3
1996	10	2	12
1997	18	1	19
1998	9	8	17
1999	13	6	19
2000	6	5	11
2001	17	5	22
2002	14	16	30
2003	24	36	60
2004	16	31	47
2005	13	33	46
2006	13	23	36
2007	29	24	53
2008	23	28	51
2009	18	25	43
2010	14	27	41
2011	12	32	44
2012	9	20	29
2013	3	17	20
2014	1	13	14
2015	5	13	18
2016	4	8	12
2017	2	18	20
2018	0	5	5
2019	0	8	8
2020	2	7	9
2021	0	4	4
2022	1	3	4

Below are the most recent publications written about "Apoptosis" by people in Profiles.

Lodhi N, Nagpal P, Sarojini S, Keck M, Chiu YM, Parvez Z, Adrianzen L, Suh KS. Synergetic effect of high dose rate radiations (10? FFF/2400 MU/min/10 MV x-rays) and paclitaxel selectively eliminates melanoma cells. Cancer Rep (Hoboken). 2023 02; 6(2):e1733.

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Ratiu JJ, Barclay WE, Lin E, Wang Q, Wellford S, Mehta N, Harnois MJ, DiPalma D, Roy S, Contreras AV, Shinohara ML, Wiest D, Zhuang Y. Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-? selection thymocytes. Nat Commun. 2022 10 06; 13(1):5901.

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Kumar S, Mulchandani V, Das Sarma J. Methanolic neem (Azadirachta indica) stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells in vitro. BMC Complement Med Ther. 2022 Sep 10; 22(1):239.

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Moellmann J, Mann PA, Kappel BA, Kahles F, Klinkhammer BM, Boor P, Kramann R, Ghesquiere B, Lebherz C, Marx N, Lehrke M. The sodium-glucose co-transporter-2 inhibitor ertugliflozin modifies the signature of cardiac substrate metabolism and reduces cardiac mTOR signalling, endoplasmic reticulum stress and apoptosis. Diabetes Obes Metab. 2022 11; 24(11):2263-2272.

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Sato K, Padgaonkar AA, Baker SJ, Cosenza SC, Rechkoblit O, Subbaiah DRCV, Domingo-Domenech J, Bartkowski A, Port ER, Aggarwal AK, Ramana Reddy MV, Irie HY, Reddy EP. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun. 2021 08 03; 12(1):4671.

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Tewary P, Brooks AD, Xu YM, Wijeratne EMK, Babyak AL, Back TC, Chari R, Evans CN, Henrich CJ, Meyer TJ, Edmondson EF, de Aquino MTP, Kanagasabai T, Shanker A, Gunatilaka AAL, Sayers TJ. Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins. Cancer Res. 2021 06 15; 81(12):3374-3386.

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Mergenthaler P, Hariharan S, Pemberton JM, Lourenco C, Penn LZ, Andrews DW. Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning. PLoS Comput Biol. 2021 02; 17(2):e1008630.

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Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nat Commun. 2021 01 20; 12(1):484.

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Nagpal P, Descalzi-Montoya DB, Lodhi N. The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes. Cancer Rep (Hoboken). 2021 04; 4(2):e1311.

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Bouchareb R, Katz M, Saadallah N, Sassi Y, Ali S, Lebeche D. Boron improves cardiac contractility and fibrotic remodeling following myocardial infarction injury. Sci Rep. 2020 10 13; 10(1):17138.

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