"Genes, APC" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
| Descriptor ID |
D017491
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.050 G05.360.340.024.340.415.400.050
|
| Concept/Terms |
Genes, APC- Genes, APC
- APC Gene
- APC Genes
- Gene, APC
- Genes, Adenomatous Polyposis Coli
|
Below are MeSH descriptors whose meaning is more general than "Genes, APC".
Below are MeSH descriptors whose meaning is more specific than "Genes, APC".
This graph shows the total number of publications written about "Genes, APC" by people in this website by year, and whether "Genes, APC" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
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Below are the most recent publications written about "Genes, APC" by people in Profiles.
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Birsner ML, Hoover-Fong J, Bytyci Telegrafi A, Hueppchen NA. Perinatal detection of familial adenomatous polyposis. Obstet Gynecol. 2012 Aug; 120(2 Pt 2):500-503.
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Nnadi SC, Watson R, Innocent J, Gonye GE, Buchberg AM, Siracusa LD. Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain. Carcinogenesis. 2012 Aug; 33(8):1589-97.
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Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1082-91.
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Crist RC, Roth JJ, Baran AA, McEntee BJ, Siracusa LD, Buchberg AM. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis. Mamm Genome. 2010 Oct; 21(9-10):450-7.
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Li P, Schulz S, Bombonati A, Palazzo JP, Hyslop TM, Xu Y, Baran AA, Siracusa LD, Pitari GM, Waldman SA. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology. 2007 Aug; 133(2):599-607.
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Markova M, Koratkar RA, Silverman KA, Sollars VE, MacPhee-Pellini M, Walters R, Palazzo JP, Buchberg AM, Siracusa LD, Farber SA. Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to Apc Min/+ tumorigenesis. Oncogene. 2005 Sep 22; 24(42):6450-8.
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Koratkar R, Silverman KA, Pequignot E, Hauck WW, Buchberg AM, Siracusa LD. Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis. Genomics. 2004 Nov; 84(5):844-52.
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Cowie S, Drmanac S, Swanson D, Delgrosso K, Huang S, du Sart D, Drmanac R, Surrey S, Fortina P. Identification of APC gene mutations in colorectal cancer using universal microarray-based combinatorial sequencing-by-hybridization. Hum Mutat. 2004 Sep; 24(3):261-71.
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Koratkar R, Pequignot E, Hauck WW, Siracusa LD. The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus. Cancer Res. 2002 Oct 01; 62(19):5413-7.
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Silverman KA, Koratkar R, Siracusa LD, Buchberg AM. Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res. 2002 Jan; 12(1):88-97.