"Clonal Deletion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also undergo clonal deletion.
Descriptor ID |
D017637
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MeSH Number(s) |
G12.535.425.120
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Concept/Terms |
Clonal Deletion- Clonal Deletion
- Clonal Deletions
- Deletion, Clonal
- Deletions, Clonal
Clonal Abortion- Clonal Abortion
- Abortion, Clonal
- Abortions, Clonal
- Clonal Abortions
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Below are MeSH descriptors whose meaning is more general than "Clonal Deletion".
Below are MeSH descriptors whose meaning is more specific than "Clonal Deletion".
This graph shows the total number of publications written about "Clonal Deletion" by people in this website by year, and whether "Clonal Deletion" was a major or minor topic of these publications.
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click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 1 | 2 |
1998 | 1 | 1 | 2 |
1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2001 | 1 | 0 | 1 |
2002 | 0 | 1 | 1 |
2003 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clonal Deletion" by people in Profiles.
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Lauritsen JP, Kurella S, Lee SY, Lefebvre JM, Rhodes M, Alberola-Ila J, Wiest DL. Egr2 is required for Bcl-2 induction during positive selection. J Immunol. 2008 Dec 01; 181(11):7778-85.
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Wen L, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K. Evidence of marginal-zone B cell-positive selection in spleen. Immunity. 2005 Sep; 23(3):297-308.
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Hardy RR. Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies. Curr Dir Autoimmun. 2003; 6:196-211.
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Notidis E, Heltemes L, Manser T. Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development. Immunity. 2002 Sep; 17(3):317-27.
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Notidis E, Hande S, Manser T. Enforced expression of Bcl-2 selectively perturbs negative selection of dual reactive antibodies. Dev Immunol. 2001; 8(3-4):223-34.
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Kruisbeek AM, Haks MC, Carleton M, Michie AM, Z??iga-Pfl?cker JC, Wiest DL. Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunol Today. 2000 Dec; 21(12):637-44.
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Dave VP, Allman D, Wiest DL, Kappes DJ. Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection. J Immunol. 1999 May 15; 162(10):5764-74.
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Dave VP, Keefe R, Berger MA, Drbal K, Punt JA, Wiest DL, Alarcon B, Kappes DJ. Altered functional responsiveness of thymocyte subsets from CD3delta-deficient mice to TCR-CD3 engagement. Int Immunol. 1998 Oct; 10(10):1481-90.
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Hande S, Notidis E, Manser T. Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development. Immunity. 1998 Feb; 8(2):189-98.
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Vora KA, Ravetch JV, Manser T. Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response. J Immunol. 1997 Sep 01; 159(5):2116-24.