Immunoglobulin Variable Region
"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
| Descriptor ID |
D007135
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| MeSH Number(s) |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
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| Concept/Terms |
Immunoglobulin Variable Region- Immunoglobulin Variable Region
- Immunoglobulin Variable Regions
- Regions, Immunoglobulin Variable
- Variable Regions, Immunoglobulin
- Ig Variable Region
- Variable Region, Ig
- Ig Variable Regions
- Variable Regions, Ig
- Variable Region, Immunoglobulin
- Immunoglobulin V
Immunoglobulin Fv Fragments- Immunoglobulin Fv Fragments
- Fragment, Immunoglobulin Fv
- Fragments, Immunoglobulin Fv
- Fv Fragment, Immunoglobulin
- Fv Fragments, Immunoglobulin
- Immunoglobulin Fv Fragment
- Fv Antibody Fragments
- Antibody Fragment, Fv
- Antibody Fragments, Fv
- Fragment, Fv Antibody
- Fragments, Fv Antibody
- Fv Antibody Fragment
- Fv Fragments
- Fragment, Fv
- Fragments, Fv
- Fv Fragment
Framework Region, Immunoglobulin- Framework Region, Immunoglobulin
- Framework Regions, Immunoglobulin
- Immunoglobulin Framework Regions
- Ig Framework Region
- Framework Region, Ig
- Framework Regions, Ig
- Ig Framework Regions
- Immunoglobulin Framework Region
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".
This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 2 | 5 |
| 1997 | 3 | 1 | 4 |
| 1998 | 2 | 1 | 3 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 4 | 4 |
| 2002 | 2 | 4 | 6 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 4 | 6 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.
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Dickinson GS, Levenson EA, Walker JA, Kearney JF, Alugupalli KR. IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity. J Immunol. 2018 08 15; 201(4):1229-1240.
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Lu J, Panavas T, Thys K, Aerssens J, Naso M, Fisher J, Rycyzyn M, Sweet RW. IgG variable region and VH CDR3 diversity in unimmunized mice analyzed by massively parallel sequencing. Mol Immunol. 2014 Feb; 57(2):274-83.
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Fertala J, Steplewski A, Kostas J, Beredjiklian P, Williams G, Arnold W, Abboud J, Bhardwaj A, Hou C, Fertala A. Engineering and characterization of the chimeric antibody that targets the C-terminal telopeptide of the a2 chain of human collagen I: a next step in the quest to reduce localized fibrosis. Connect Tissue Res. 2013; 54(3):187-96.
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Schiefner A, Chatwell L, K?rner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol. 2011 Dec 02; 414(3):337-55.
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Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 01; 187(1):212-21.
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Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ. Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol. 2009 Mar 15; 182(6):3583-96.
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Coffey F, Liu X, Manser T. Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs. J Immunol. 2007 Nov 15; 179(10):6663-72.
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Liu X, Wysocki LJ, Manser T. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci. J Immunol. 2007 Apr 15; 178(8):5035-47.
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Wang Y, Ylera F, Boston M, Kang SG, Kutok JL, Klein-Szanto AJ, Junghans RP. Focused antibody response in plasma cell-infiltrated non-medullary (NOS) breast cancers. Breast Cancer Res Treat. 2007 Aug; 104(2):129-44.
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Heltemes-Harris L, Liu X, Manser T. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005 Nov; 17(11):1447-61.