Transcription Factor AP-1

"Transcription Factor AP-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Descriptor ID	D018808
MeSH Number(s)	D12.776.260.108.875 D12.776.930.127.875
Concept/Terms	Transcription Factor AP-1 Transcription Factor AP-1 Transcription Factor AP 1 AP-1 Enhancer-Binding Protein Enhancer-Binding Protein, AP-1 AP-1 Activator Protein-1 Activator Protein 1 AP-1 Enhancer Binding Protein AP 1 Enhancer Binding Protein

Below are MeSH descriptors whose meaning is more general than "Transcription Factor AP-1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Transcription Factor AP-1 [D12.776.260.108.875]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Transcription Factor AP-1 [D12.776.930.127.875]

Below are MeSH descriptors whose meaning is related to "Transcription Factor AP-1".

Below are MeSH descriptors whose meaning is more specific than "Transcription Factor AP-1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Factor AP-1" by people in this website by year, and whether "Transcription Factor AP-1" was a major or minor topic of these publications.

Bar chart showing 33 publications over 17 distinct years, with a maximum of 5 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	3	3
1996	0	1	1
1997	1	0	1
1999	1	1	2
2000	0	1	1
2001	0	1	1
2002	0	4	4
2003	1	4	5
2004	0	1	1
2006	0	3	3
2007	0	1	1
2008	0	1	1
2010	3	1	4
2011	0	1	1
2012	1	1	2
2015	0	1	1

Below are the most recent publications written about "Transcription Factor AP-1" by people in Profiles.

Yin Y, Li X, Sha X, Xi H, Li YF, Shao Y, Mai J, Virtue A, Lopez-Pastrana J, Meng S, Tilley DG, Monroy MA, Choi ET, Thomas CJ, Jiang X, Wang H, Yang XF. Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):804-16.

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Kinoshita SM, Krutzik PO, Nolan GP. COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One. 2012; 7(7):e41725.

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Yan Y, Zhang GX, Williams MS, Carey GB, Li H, Yang J, Rostami A, Xu H. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Mol Immunol. 2012 Sep; 52(2):71-8.

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Arendt LM, Rugowski DE, Grafwallner-Huseth TA, Garcia-Barchino MJ, Rui H, Schuler LA. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer. Breast Cancer Res. 2011; 13(1):R11.

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Miller GM, Ogunnaike BA, Schwaber JS, Vadigepalli R. Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network. BMC Syst Biol. 2010; 4:171.

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Katiyar S, Casimiro MC, Dettin L, Ju X, Wagner EF, Tanaka H, Pestell RG. C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell. 2010 Dec; 21(23):4264-74.

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Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis Rheum. 2010 Jul; 62(7):1983-92.

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Hiyama A, Gogate SS, Gajghate S, Mochida J, Shapiro IM, Risbud MV. BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res. 2010 May; 25(5):1179-90.

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Vasilevskaya IA, Selvakumaran M, O'Dwyer PJ. Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin. Mol Pharmacol. 2008 Jul; 74(1):246-54.

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Rao M, Casimiro MC, Lisanti MP, D'Amico M, Wang C, Shirley LA, Leader JE, Liu M, Stallcup M, Engel DA, Murphy DJ, Pestell RG. Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle. 2008 Mar 1; 7(5):647-55.

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