CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody.
Awan FT, Lapalombella R, Trotta R, Butchar JP, Yu B, Benson DM, Roda JM, Cheney C, Mo X, Lehman A, Jones J, Flynn J, Jarjoura D, Desjarlais JR, Tridandapani S, Caligiuri MA, Muthusamy N, Byrd JC. CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody. Blood. 2010 Feb 11; 115(6):1204-13.
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Antibodies, Monoclonal
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Antibody-Dependent Cell Cytotoxicity
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Antigens, CD19
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Apoptosis
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Blotting, Western
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Cytotoxicity, Immunologic
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Extracellular Signal-Regulated MAP Kinases
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Flow Cytometry
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Granzymes
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Humans
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Immunoglobulin Fc Fragments
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Killer Cells, Natural
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Leukemia, B-Cell
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Leukemia, Lymphocytic, Chronic, B-Cell
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Phagocytosis
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Phosphorylation
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger