"Trans-Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
| Descriptor ID |
D020040
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| MeSH Number(s) |
G02.111.760.700.750 G03.839.700.750 G05.308.700.700.750
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| Concept/Terms |
Trans-Splicing- Trans-Splicing
- Trans Splicing
- Splicing, Trans
- RNA Trans-Splicing
- RNA Trans Splicing
- Trans-Splicings, RNA
- Trans RNA Splicing
- RNA Splicing, Trans
|
Below are MeSH descriptors whose meaning is more general than "Trans-Splicing".
Below are MeSH descriptors whose meaning is more specific than "Trans-Splicing".
This graph shows the total number of publications written about "Trans-Splicing" by people in this website by year, and whether "Trans-Splicing" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Trans-Splicing" by people in Profiles.
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Butchbach ME. Trans-splicing, more than meets the eye: multifaceted therapeutics for spinal muscular atrophy. Hum Gene Ther. 2011 Feb; 22(2):121-5.
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Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J, Blazar BR. Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery. Mol Ther. 2007 Jul; 15(7):1273-9.