Thomas Jefferson University

Michael Greenberg

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentRadiation Oncology
Address4900 Frankford Ave
Philadelphia PA 19124
Phone856-757-9010
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    F32GM097889     (GREENBERG, MICHAEL J)May 1, 2011 - Apr 30, 2013
    NIH
    Regulation of Myosin Ic Mechanochemistry
    Role: Principal Investigator
    K99HL123623     (GREENBERG, MICHAEL J)Aug 1, 2014 - Jul 31, 2015
    NIH
    Regulation of cardiac power output in health and disease
    Role: Principal Investigator
    R00HL123623     (GREENBERG, MICHAEL J)Aug 1, 2014 - Jun 30, 2018
    NIH
    Regulation of cardiac power output in health and disease
    Role: Principal Investigator
    R01HL141086     (GREENBERG, MICHAEL J)Apr 1, 2018 - Mar 31, 2024
    NIH
    Regulation of cardiac power output in health and disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Greenberg MJ. Super Relaxed or Super Stressed: Modeling Length-Dependent Activation in Cardiac Muscle. Biophys J. 2024 Jul 26. PMID: 39068513.
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    2. Lin Z, Xie Y, Gongora J, Liu X, Zahn E, Palai BB, Ramirez D, Searfoss RM, Vitorino FN, Dann GP, Zhao C, Han X, MacTaggart B, Lan X, Fu D, Greenberg L, Zhang Y, Lavine KJ, Greenberg MJ, Lv D, Kashina A, Garcia BA. An Unbiased Proteomic Platform for Activity-based Arginylation Profiling. bioRxiv. 2024 Jun 02. PMID: 38854050.
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    3. Cubuk J, Greenberg L, Greenberg AE, Emenecker RJ, Stuchell-Brereton MD, Holehouse AS, Soranno A, Greenberg MJ. Structural dynamics of the intrinsically disordered linker region of cardiac troponin T. bioRxiv. 2024 May 31. PMID: 38853835.
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    4. Meyer GA, Ferey JLA, Sanford JA, Fitzgerald LS, Greenberg AE, Svensson K, Greenberg MJ, Schenk S. Insights into posttranslational regulation of skeletal muscle contractile function by the acetyltransferases, p300 and CBP. J Appl Physiol (1985). 2024 Jun 01; 136(6):1559-1567. PMID: 38722753.
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    5. Greenberg L, Tom Stump W, Lin Z, Bredemeyer AL, Blackwell T, Han X, Greenberg AE, Garcia BA, Lavine KJ, Greenberg MJ. Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T. bioRxiv. 2024 Apr 09. PMID: 38645235.
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    6. Garg A, Jansen S, Zhang R, Lavine KJ, Greenberg MJ. Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility. bioRxiv. 2024 Mar 12. PMID: 38559046.
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    7. Meyer GA, Ferey JLA, Sanford JA, Fitzgerald LS, Greenberg AE, Svensson K, Greenberg MJ, Schenk S. Insights into post-translational regulation of skeletal muscle contractile function by the acetyltransferases, p300 and CBP. bioRxiv. 2024 Feb 29. PMID: 38463996.
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    8. Vera R, Hong N, Jiang B, Liang G, Eckenhoff MF, Kincaid HJ, Browne V, Chellaraj V, Gisewhite D, Greenberg M, Ranjan S, Zhu G, Wei H. Effects of Intranasal Dantrolene Nanoparticles on Brain Concentration and Behavior in PS19 Tau Transgenic Mice. J Alzheimers Dis. 2024 Feb 23. PMID: 38393915.
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    9. Ghahremani S, Kanwal A, Pettinato A, Ladha F, Legere N, Thakar K, Zhu Y, Tjong H, Wilderman A, Stump WT, Greenberg L, Greenberg MJ, Cotney J, Wei CL, Hinson JT. CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants. Circulation. 2024 Jan 18. PMID: 38235591.
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    10. Scott B, Greenberg MJ. Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas. Biophys J. 2023 Nov 24. PMID: 38006882.
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    11. Garg A, Lavine KJ, Greenberg MJ. Assessing Cardiac Contractility From Single Molecules to Whole Hearts. JACC Basic Transl Sci. 2024 Mar; 9(3):414-439. PMID: 38559627.
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    12. Lehman SJ, Meller A, Solieva SO, Lotthammer JM, Greenberg L, Langer SJ, Greenberg MJ, Tardiff JC, Bowman GR, Leinwand L. Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies. bioRxiv. 2023 Jul 03. PMID: 37461648.
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    13. Clippinger Schulte SR, Scott B, Barrick SK, Stump WT, Blackwell T, Greenberg MJ. Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments. Biophys J. 2023 May 10. PMID: 37165621.
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    14. Lee LA, Barrick SK, Buvoli AE, Walklate J, Stump WT, Geeves M, Greenberg MJ, Leinwand LA. Distinct effects of two hearing loss-associated mutations in the sarcomeric myosin MYH7b. J Biol Chem. 2023 Mar 22; 104631. PMID: 36963494.
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    15. Barrick SK, Garg A, Greenberg L, Zhang S, Lin CY, Stitziel NO, Greenberg MJ. Functional assays reveal the pathogenic mechanism of a de novo tropomyosin variant identified in patient with dilated cardiomyopathy. J Mol Cell Cardiol. 2023 Feb 03; 176:58-67. PMID: 36739943.
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    16. Meller A, Lotthammer JM, Smith LG, Novak B, Lee LA, Kuhn CC, Greenberg L, Leinwand LA, Greenberg MJ, Bowman GR. Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains. Elife. 2023 Jan 27; 12. PMID: 36705568.
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    17. Clippinger Schulte SR, Scott B, Barrick SK, Stump WT, Blackwell T, Greenberg MJ. Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments. bioRxiv. 2023 Jan 10. PMID: 36711892.
      Citations:    
    18. Lee LA, Barrick SK, Meller A, Walklate J, Lotthammer JM, Tay JW, Stump WT, Bowman G, Geeves MA, Greenberg MJ, Leinwand LA. Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles. J Biol Chem. 2023 01; 299(1):102657. PMID: 36334627.
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    19. McAdow J, Yang S, Ou T, Huang G, Dobbs MB, Gurnett CA, Greenberg MJ, Johnson AN. A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis. JCI Insight. 2022 06 22; 7(12). PMID: 35579956.
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    20. Barrick SK, Greenberg MJ. Cardiac myosin contraction and mechanotransduction in health and disease. J Biol Chem. 2021 11; 297(5):101297. PMID: 34634306.
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    21. Papadaki M, Kampaengsri T, Barrick SK, Campbell SG, von Lewinski D, Rainer PP, Harris SP, Greenberg MJ, Kirk JA. Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains. J Mol Cell Cardiol. 2022 01; 162:1-9. PMID: 34487755.
      Citations:    
    22. Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity. 2021 09 14; 54(9):2072-2088.e7. PMID: 34320366.
      Citations:    
    23. Barrick SK, Greenberg L, Greenberg MJ. A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding. Mol Biol Cell. 2021 08 19; 32(18):1677-1689. PMID: 34161147.
      Citations:    
    24. Clippinger SR, Cloonan PE, Wang W, Greenberg L, Stump WT, Angsutararux P, Nerbonne JM, Greenberg MJ. Mechanical dysfunction of the sarcomere induced by a pathogenic mutation in troponin T drives cellular adaptation. J Gen Physiol. 2021 05 03; 153(5). PMID: 33856419.
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    25. Greenberg MJ, Tardiff JC. Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine. J Gen Physiol. 2021 03 01; 153(3). PMID: 33512404.
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    26. Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Zhang X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. SARS-CoV-2 Infects Human Engineered?Heart Tissues and Models COVID-19 Myocarditis. JACC Basic Transl Sci. 2021 Apr; 6(4):331-345. PMID: 33681537.
      Citations:    
    27. Blackwell T, Stump WT, Clippinger SR, Greenberg MJ. Computational Tool for Ensemble Averaging of Single-Molecule Data. Biophys J. 2021 01 05; 120(1):10-20. PMID: 33248132.
      Citations:    
    28. Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Lai L, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis. bioRxiv. 2020 Nov 05. PMID: 33173875.
      Citations:    
    29. Lavine KJ, Greenberg MJ. Beyond genomics-technological advances improving the molecular characterization and precision treatment of heart failure. Heart Fail Rev. 2021 03; 26(2):405-415. PMID: 32885327.
      Citations:    
    30. Porter JR, Meller A, Zimmerman MI, Greenberg MJ, Bowman GR. Conformational distributions of isolated myosin motor domains encode their mechanochemical properties. Elife. 2020 05 29; 9. PMID: 32479265.
      Citations:    
    31. Ezekian JE, Clippinger SR, Garcia JM, Yang Q, Denfield S, Jeewa A, Dreyer WJ, Zou W, Fan Y, Allen HD, Kim JJ, Greenberg MJ, Landstrom AP. Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. J Am Heart Assoc. 2020 03 03; 9(5):e015111. PMID: 32098556.
      Citations:    
    32. Clippinger SR, Cloonan PE, Greenberg L, Ernst M, Stump WT, Greenberg MJ. Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17831-17840. PMID: 31427533.
      Citations:    
    33. Barrick SK, Clippinger SR, Greenberg L, Greenberg MJ. Computational Tool to Study Perturbations in?Muscle Regulation and Its Application to?Heart?Disease. Biophys J. 2019 06 18; 116(12):2246-2252. PMID: 31126584.
      Citations:    
    34. Porter JR, Moeder KE, Sibbald CA, Zimmerman MI, Hart KM, Greenberg MJ, Bowman GR. Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling. Biophys J. 2019 03 05; 116(5):818-830. PMID: 30744991.
      Citations:    
    35. Woody MS, Greenberg MJ, Barua B, Winkelmann DA, Goldman YE, Ostap EM. Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke. Nat Commun. 2018 09 21; 9(1):3838. PMID: 30242219.
      Citations:    
    36. Greenberg MJ, Daily NJ, Wang A, Conway MK, Wakatsuki T. Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery. Front Cardiovasc Med. 2018; 5:120. PMID: 30283789.
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    37. Greenberg MJ, Shuman H, Ostap EM. Measuring the Kinetic and Mechanical Properties of Non-processive Myosins Using Optical Tweezers. Methods Mol Biol. 2017; 1486:483-509. PMID: 27844441.
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    38. Woody MS, Lewis JH, Greenberg MJ, Goldman YE, Ostap EM. MEMLET: An Easy-to-Use Tool for Data Fitting and Model Comparison Using Maximum-Likelihood Estimation. Biophys J. 2016 Jul 26; 111(2):273-282. PMID: 27463130.
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    39. Greenberg MJ, Arpag G, T?zel E, Ostap EM. A Perspective on the Role of Myosins as Mechanosensors. Biophys J. 2016 Jun 21; 110(12):2568-2576. PMID: 27332116.
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    40. Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC. An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake. Traffic. 2016 Jan; 17(1):80-1. PMID: 26688443.
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    41. Greenberg MJ, Lin T, Shuman H, Ostap EM. Mechanochemical tuning of myosin-I by the N-terminal region. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3337-44. PMID: 26056287.
      Citations:    
    42. Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC. An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake. Traffic. 2015 Jul; 16(7):691-711. PMID: 25783006.
      Citations:    
    43. Greenberg MJ, Shuman H, Ostap EM. Inherent force-dependent properties of ?-cardiac myosin contribute to the force-velocity relationship of cardiac muscle. Biophys J. 2014 Dec 16; 107(12):L41-L44. PMID: 25517169.
      Citations:    
    44. Shuman H, Greenberg MJ, Zwolak A, Lin T, Sindelar CV, Dominguez R, Ostap EM. A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2116-21. PMID: 24469830.
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    45. Greenberg MJ, Ostap EM. Regulation and control of myosin-I by the motor and light chain-binding domains. Trends Cell Biol. 2013 Feb; 23(2):81-9. PMID: 23200340.
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    46. Greenberg MJ, Lin T, Goldman YE, Shuman H, Ostap EM. Myosin IC generates power over a range of loads via a new tension-sensing mechanism. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):E2433-40. PMID: 22908250.
      Citations:    
    47. Lewis JH, Greenberg MJ, Laakso JM, Shuman H, Ostap EM. Calcium regulation of myosin-I tension sensing. Biophys J. 2012 Jun 20; 102(12):2799-807. PMID: 22735530.
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    48. Chen C, Greenberg MJ, Laakso JM, Ostap EM, Goldman YE, Shuman H. Kinetic schemes for post-synchronized single molecule dynamics. Biophys J. 2012 Mar 21; 102(6):L23-5. PMID: 22455931.
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    49. Sorokin V, Persechino F, DeRoux SJ, Greenberg MJ. Suicidal ligature strangulation utilizing cable ties: a report of three cases. Forensic Sci Med Pathol. 2012 Mar; 8(1):52-5. PMID: 21901550.
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    50. Lin T, Greenberg MJ, Moore JR, Ostap EM. A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity. Biochemistry. 2011 Mar 22; 50(11):1831-8. PMID: 21265502.
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    51. Greenberg MJ, Kazmierczak K, Szczesna-Cordary D, Moore JR. Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17403-8. PMID: 20855589.
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    52. Greenberg MJ, Moore JR. The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors. Cytoskeleton (Hoboken). 2010 May; 67(5):273-85. PMID: 20191566.
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    53. Greenberg MJ, Mealy TR, Jones M, Szczesna-Cordary D, Moore JR. The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R989-96. PMID: 20089714.
      Citations:    
    54. Greenberg MJ, Moore JR. Actin in action and inaction: the differential effects of hypertrophic and dilated cardiomyopathy actin mutations on thin filament regulation. J Mol Cell Cardiol. 2010 Feb; 48(2):277-8. PMID: 19879279.
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    55. Pant K, Watt J, Greenberg M, Jones M, Szczesna-Cordary D, Moore JR. Removal of the cardiac myosin regulatory light chain increases isometric force production. FASEB J. 2009 Oct; 23(10):3571-80. PMID: 19470801.
      Citations:    
    56. Greenberg MJ, Mealy TR, Watt JD, Jones M, Szczesna-Cordary D, Moore JR. The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation. Am J Physiol Regul Integr Comp Physiol. 2009 Aug; 297(2):R265-74. PMID: 19458282.
      Citations:    
    57. Greenberg MJ. William D. Cohen: Biologist, Educator, Editor (1938-2008). Biol Bull. 2008 Dec; 215(3):201-203. PMID: 27700143.
      Citations:    
    58. Greenberg MJ, Watt JD, Jones M, Kazmierczak K, Szczesna-Cordary D, Moore JR. Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics. J Mol Cell Cardiol. 2009 Jan; 46(1):108-15. PMID: 18929571.
      Citations:    
    59. Elliott EA, Wright JR, Swann RS, Nguyen-T?n F, Takita C, Bucci MK, Garden AS, Kim H, Hug EB, Ryu J, Greenberg M, Saxton JP, Ang K, Berk L. Phase III Trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13. J Clin Oncol. 2006 May 01; 24(13):2092-7. PMID: 16648511.
      Citations:    
    60. Gainey LF, Greenberg MJ. Hydrogen sulfide is synthesized in the gills of the clam Mercenaria mercenaria and acts seasonally to modulate branchial muscle contraction. Biol Bull. 2005 Aug; 209(1):11-20. PMID: 16110090.
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    61. Gainey LF, Greenberg MJ. Nitric oxide mediates seasonal muscle potentiation in clam gills. J Exp Biol. 2003 Oct; 206(Pt 19):3507-20. PMID: 12939381.
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    62. Gainey LF, Walton JC, Greenberg MJ. Branchial musculature of a venerid clam: pharmacology, distribution, and innervation. Biol Bull. 2003 Feb; 204(1):81-95. PMID: 12588747.
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    63. Machtay M, Rosenthal DI, Hershock D, Jones H, Williamson S, Greenberg MJ, Weinstein GS, Aviles VM, Chalian AA, Weber RS. Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: a University of Pennsylvania Phase II Trial. J Clin Oncol. 2002 Oct 01; 20(19):3964-71. PMID: 12351593.
      Citations:    
    64. Watts JA, Koch RA, Greenberg MJ, Pierce SK. Ultrastructure of the heart of the marine mussel, Geukensia demissa. J Morphol. 1981 Dec; 170(3):301-319. PMID: 30153711.
      Citations:    
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