Cyclin-Dependent Kinase 9
"Cyclin-Dependent Kinase 9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION, and APOPTOSIS. It is found associated with CYCLIN T and is a component of POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B.
| Descriptor ID |
D042863
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| MeSH Number(s) |
D08.811.641.752 D08.811.913.696.620.682.700.646.500.500.750 D12.644.360.250.067.900 D12.776.167.200.067.900 D12.776.476.250.067.900 D12.776.930.955.500.500
|
| Concept/Terms |
Cyclin-Dependent Kinase 9- Cyclin-Dependent Kinase 9
- Cyclin Dependent Kinase 9
- PITALRE Kinase
- Cdk9 Protein Kinase
- CDK9 Kinase
- Cdc2-related Kinase PITALRE
- Cdc2 related Kinase PITALRE
- Kinase PITALRE, Cdc2-related
- PITALRE, Cdc2-related Kinase
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 9".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 9".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 9" by people in this website by year, and whether "Cyclin-Dependent Kinase 9" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 6 | 6 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 3 | 1 | 4 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 9" by people in Profiles.
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Sharma AL, Tyagi P, Khumallambam M, Tyagi M. Cocaine-Induced DNA-Dependent Protein Kinase Relieves RNAP II Pausing by Promoting TRIM28 Phosphorylation and RNAP II Hyperphosphorylation to Enhance HIV Transcription. Cells. 2024 Nov 23; 13(23).
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Walker RL, Hornicek FJ, Duan Z. Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma. Biochem Pharmacol. 2024 08; 226:116342.
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Boffo S, Damato A, Alfano L, Giordano A. CDK9 inhibitors in acute myeloid leukemia. J Exp Clin Cancer Res. 2018 Feb 23; 37(1):36.
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Morales F, Giordano A. Overview of CDK9 as a target in cancer research. Cell Cycle. 2016; 15(4):519-27.
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Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1. Retrovirology. 2015 Jul 16; 12:63.
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Marchesi I, Nieddu V, Caracciolo V, Maioli M, Gaspa L, Giordano A, Bagella L. Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation. J Cell Biochem. 2013 Mar; 114(3):728-34.
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Caracciolo V, Laurenti G, Romano G, Carnevale V, Cimini AM, Crozier-Fitzgerald C, Gentile Warschauer E, Russo G, Giordano A. Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development. Cell Cycle. 2012 Mar 15; 11(6):1202-16.
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Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96.
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Romano G, Giordano A. Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases. Cell Cycle. 2008 Dec; 7(23):3664-8.
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Giacinti C, Musar? A, De Falco G, Jourdan I, Molinaro M, Bagella L, Simone C, Giordano A. Cdk9-55: a new player in muscle regeneration. J Cell Physiol. 2008 Sep; 216(3):576-82.