"Chromosomal Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Descriptor ID |
D043171
|
| MeSH Number(s) |
C23.550.210.110 C23.550.362.180 G05.365.590.175.165 G05.370.180
|
| Concept/Terms |
Chromosomal Instability- Chromosomal Instability
- Chromosomal Instabilities
- Instabilities, Chromosomal
- Instability, Chromosomal
- Chromosome Instability
- Chromosome Instabilities
- Instabilities, Chromosome
- Instability, Chromosome
Chromosome Stability- Chromosome Stability
- Chromosome Stabilities
- Stabilities, Chromosome
- Stability, Chromosome
- Chromosomal Stability
- Chromosomal Stabilities
- Stabilities, Chromosomal
- Stability, Chromosomal
|
Below are MeSH descriptors whose meaning is more general than "Chromosomal Instability".
Below are MeSH descriptors whose meaning is more specific than "Chromosomal Instability".
This graph shows the total number of publications written about "Chromosomal Instability" by people in this website by year, and whether "Chromosomal Instability" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosomal Instability" by people in Profiles.
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Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. PLoS One. 2013; 8(11):e80228.
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Mishra A, Liu S, Sams GH, Curphey DP, Santhanam R, Rush LJ, Schaefer D, Falkenberg LG, Sullivan L, Jaroncyk L, Yang X, Fisk H, Wu LC, Hickey C, Chandler JC, Wu YZ, Heerema NA, Chan KK, Perrotti D, Zhang J, Porcu P, Racke FK, Garzon R, Lee RJ, Marcucci G, Caligiuri MA. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell. 2012 Nov 13; 22(5):645-55.
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Casimiro MC, Pestell RG. Cyclin d1 induces chromosomal instability. Oncotarget. 2012 Mar; 3(3):224-5.
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Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012 Mar 1; 122(3):833-43.
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Bouska A, Eischen CM. Murine double minute 2: p53-independent roads lead to genome instability or death. Trends Biochem Sci. 2009 Jun; 34(6):279-86.
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Hucl T, Rago C, Gallmeier E, Brody JR, Gorospe M, Kern SE. A syngeneic variance library for functional annotation of human variation: application to BRCA2. Cancer Res. 2008 Jul 1; 68(13):5023-30.
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Sato N, Fukushima N, Matsubayashi H, Iacobuzio-Donahue CA, Yeo CJ, Goggins M. Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma. Cancer. 2006 Jul 15; 107(2):251-7.