DNA-(Apurinic or Apyrimidinic Site) Lyase
"DNA-(Apurinic or Apyrimidinic Site) Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Descriptor ID |
D043603
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MeSH Number(s) |
D08.811.074.750 D08.811.520.241.225
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Concept/Terms |
DNA-(Apurinic or Apyrimidinic Site) Lyase- DNA-(Apurinic or Apyrimidinic Site) Lyase
- AP Endonuclease
- Endonuclease, AP
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
- Apurine-Apyrimidine Endonuclease
- Apurine Apyrimidine Endonuclease
- Endonuclease, Apurine-Apyrimidine
- Apurinic DNA Endonuclease
- DNA Endonuclease, Apurinic
- Endonuclease, Apurinic DNA
- Apurinic Endonuclease
- Endonuclease, Apurinic
- DNA Lyase (Apurinic or Apyrimidinic)
- AP Lyase
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Below are MeSH descriptors whose meaning is more general than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
Below are MeSH descriptors whose meaning is more specific than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
This graph shows the total number of publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in this website by year, and whether "DNA-(Apurinic or Apyrimidinic Site) Lyase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1998 | 0 | 1 | 1 |
2000 | 0 | 3 | 3 |
2007 | 0 | 1 | 1 |
2010 | 1 | 0 | 1 |
2012 | 1 | 1 | 2 |
2014 | 2 | 0 | 2 |
2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in Profiles.
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Richter C, Marquardt S, Li F, Spitschak A, Murr N, Edelh?user BAH, Iliakis G, P?tzer BM, Logotheti S. Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness. J Exp Clin Cancer Res. 2019 Jul 08; 38(1):292.
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Hong S, Hashimoto H, Kow YW, Zhang X, Cheng X. The carboxy-terminal domain of ROS1 is essential for 5-methylcytosine DNA glycosylase activity. J Mol Biol. 2014 Nov 11; 426(22):3703-3712.
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Strande NT, Carvajal-Garcia J, Hallett RA, Waters CA, Roberts SA, Strom C, Kuhlman B, Ramsden DA. Requirements for 5'dRP/AP lyase activity in Ku. Nucleic Acids Res. 2014; 42(17):11136-43.
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Longoni M, Lage K, Russell MK, Loscertales M, Abdul-Rahman OA, Baynam G, Bleyl SB, Brady PD, Breckpot J, Chen CP, Devriendt K, Gillessen-Kaesbach G, Grix AW, Rope AF, Shimokawa O, Strauss B, Wieczorek D, Zackai EH, Coletti CM, Maalouf FI, Noonan KM, Park JH, Tracy AA, Lee C, Donahoe PK, Pober BR. Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks. Am J Med Genet A. 2012 Dec; 158A(12):3148-58.
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Strande N, Roberts SA, Oh S, Hendrickson EA, Ramsden DA. Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends. J Biol Chem. 2012 Apr 20; 287(17):13686-93.
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Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA. Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature. 2010 Apr 22; 464(7292):1214-7.
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Jin X, Zhang Z, Beer-Stolz D, Zimmers TA, Koniaris LG. Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection. Hepatology. 2007 Sep; 46(3):802-12.
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Nicolas E, Beggs JM, Taraschi TF. Gelonin is an unusual DNA glycosylase that removes adenine from single-stranded DNA, normal base pairs and mismatches. J Biol Chem. 2000 Oct 06; 275(40):31399-406.
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Haltiwanger BM, Matsumoto Y, Nicolas E, Dianov GL, Bohr VA, Taraschi TF. DNA base excision repair in human malaria parasites is predominantly by a long-patch pathway. Biochemistry. 2000 Feb 01; 39(4):763-72.
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Haltiwanger BM, Karpinich NO, Taraschi TF. Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum. Biochem J. 2000 Jan 01; 345 Pt 1:85-9.