Proteasome Endopeptidase Complex

"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Descriptor ID	D046988
MeSH Number(s)	D05.500.562.500 D08.811.277.656.918 D08.811.600.730
Concept/Terms	Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex Complex, Proteasome Endopeptidase Endopeptidase Complex, Proteasome Macropain Macroxyproteinase Multicatalytic Proteinase Proteinase, Multicatalytic Prosome Proteasome 20S Proteasome Proteasome, 20S Multicatalytic Endopeptidase Complex Complex, Multicatalytic Endopeptidase Endopeptidase Complex, Multicatalytic Ingensin Ingensin

Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Proteasome Endopeptidase Complex [D05.500.562.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Proteasome Endopeptidase Complex [D08.811.277.656.918]
Multienzyme Complexes [D08.811.600]
Proteasome Endopeptidase Complex [D08.811.600.730]

Below are MeSH descriptors whose meaning is related to "Proteasome Endopeptidase Complex".

Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.

Bar chart showing 80 publications over 23 distinct years, with a maximum of 9 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2000	0	3	3
2001	0	2	2
2002	1	3	4
2003	0	8	8
2004	0	4	4
2005	3	0	3
2006	0	4	4
2008	1	1	2
2009	0	2	2
2010	2	2	4
2011	6	3	9
2012	2	2	4
2013	1	5	6
2014	3	1	4
2015	3	1	4
2016	0	4	4
2017	0	1	1
2018	3	1	4
2019	0	2	2
2020	0	1	1
2021	1	2	3
2023	0	1	1

Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.

Mancarella C, Morrione A, Scotlandi K. PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas. Int J Mol Sci. 2023 Nov 15; 24(22).

View in: PubMed
Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D. Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer. Cell Chem Biol. 2022 03 17; 29(3):358-372.e5.

View in: PubMed
Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation. Nat Commun. 2021 08 18; 12(1):5010.

View in: PubMed
Shaghaghi H, Cuevas-Mora K, Para R, Tran C, Roque W, Robertson MJ, Rosas IO, Summer R, Romero F. A model of the aged lung epithelium in idiopathic pulmonary fibrosis. Aging (Albany NY). 2021 07 08; 13(13):16922-16937.

View in: PubMed
Rusmini P, Cristofani R, Tedesco B, Ferrari V, Messi E, Piccolella M, Casarotto E, Chierichetti M, Cicardi ME, Galbiati M, Geroni C, Lombardi P, Crippa V, Poletti A. Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives. Int J Mol Sci. 2020 May 13; 21(10).

View in: PubMed
Chi JJ, Li H, Zhou Z, Izquierdo-Ferrer J, Xue Y, Wavelet CM, Schiltz GE, Zhang B, Cristofanilli M, Lu X, Bahar I, Wan Y. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Nov; 49:40-54.

View in: PubMed
Thomas S, Hoxha K, Tran A, Prendergast GC. Bin1 antibody lowers the expression of phosphorylated Tau in Alzheimer's disease. J Cell Biochem. 2019 10; 120(10):18320-18331.

View in: PubMed
Roque W, Summer R, Romero F. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis. Connect Tissue Res. 2019 01; 60(1):50-61.

View in: PubMed
Shukla SK, Rafiq K. Proteasome biology and therapeutics in cardiac diseases. Transl Res. 2019 03; 205:64-76.

View in: PubMed
Cicardi ME, Cristofani R, Rusmini P, Meroni M, Ferrari V, Vezzoli G, Tedesco B, Piccolella M, Messi E, Galbiati M, Boncoraglio A, Carra S, Crippa V, Poletti A. Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells. Sci Rep. 2018 08 17; 8(1):12390.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement