Receptors, Guanylate Cyclase-Coupled

"Receptors, Guanylate Cyclase-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell.

Descriptor ID	D050705
MeSH Number(s)	D08.811.520.650.600.500 D12.776.543.750.700
Concept/Terms	Receptors, Guanylate Cyclase-Coupled Receptors, Guanylate Cyclase-Coupled Cyclase-Coupled Receptors, Guanylate Receptors, Guanylate Cyclase Coupled Guanylyl Cyclase-Linked Receptors Cyclase-Linked Receptors, Guanylyl Guanylyl Cyclase Linked Receptors Receptors, Guanylyl Cyclase-Linked Guanylate Cyclase-Coupled Receptors Guanylate Cyclase Coupled Receptors Guanylyl Cyclase Receptors Cyclase Receptors, Guanylyl Receptors, Guanylyl Cyclase

Below are MeSH descriptors whose meaning is more general than "Receptors, Guanylate Cyclase-Coupled".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Phosphorus-Oxygen Lyases [D08.811.520.650]
Guanylate Cyclase [D08.811.520.650.600]
Receptors, Guanylate Cyclase-Coupled [D08.811.520.650.600.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Guanylate Cyclase-Coupled [D12.776.543.750.700]

Below are MeSH descriptors whose meaning is related to "Receptors, Guanylate Cyclase-Coupled".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Guanylate Cyclase-Coupled".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Guanylate Cyclase-Coupled" by people in this website by year, and whether "Receptors, Guanylate Cyclase-Coupled" was a major or minor topic of these publications.

Bar chart showing 44 publications over 10 distinct years, with a maximum of 10 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2005	0	5	5
2006	0	4	4
2007	0	3	3
2008	0	5	5
2009	0	10	10
2010	2	2	4
2011	3	1	4
2012	3	0	3
2017	3	0	3

Below are the most recent publications written about "Receptors, Guanylate Cyclase-Coupled" by people in Profiles.

Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 Sep 15; 77(18):5095-5106.

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Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol. 2017 May; 10(5):549-557.

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Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE. Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells. J Immunol. 2017 May 01; 198(9):3507-3514.

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Gong JP, Schulz S, Hyslop T, Waldman SA. GUCY2C molecular staging personalizes colorectal cancer patient management. Biomark Med. 2012 Jun; 6(3):339-48.

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Mejia A, Schulz S, Hyslop T, Weinberg DS, Waldman SA. Molecular staging individualizing cancer management. J Surg Oncol. 2012 Apr 1; 105(5):468-74.

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Lin JE, Snook AE, Li P, Stoecker BA, Kim GW, Magee MS, Garcia AV, Valentino MA, Hyslop T, Schulz S, Waldman SA. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One. 2012; 7(2):e31686.

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Snook AE, Magee MS, Waldman SA. GUCY2C-targeted cancer immunotherapy: past, present and future. Immunol Res. 2011 Dec; 51(2-3):161-9.

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Snook AE, Magee MS, Marszalowicz GP, Schulz S, Waldman SA. Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C. Cancer Immunol Immunother. 2012 May; 61(5):713-23.

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Valentino MA, Lin JE, Snook AE, Li P, Kim GW, Marszalowicz G, Magee MS, Hyslop T, Schulz S, Waldman SA. A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. J Clin Invest. 2011 Sep; 121(9):3578-88.

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Hyslop T, Weinberg DS, Schulz S, Barkun A, Waldman SA. Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer. Clin Cancer Res. 2011 May 15; 17(10):3293-303.

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