Receptors, Guanylate Cyclase-Coupled

"Receptors, Guanylate Cyclase-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell.

Descriptor ID	D050705
MeSH Number(s)	D08.811.520.650.600.500 D12.776.543.750.700
Concept/Terms	Receptors, Guanylate Cyclase-Coupled Receptors, Guanylate Cyclase-Coupled Cyclase-Coupled Receptors, Guanylate Receptors, Guanylate Cyclase Coupled Guanylyl Cyclase-Linked Receptors Cyclase-Linked Receptors, Guanylyl Guanylyl Cyclase Linked Receptors Receptors, Guanylyl Cyclase-Linked Guanylate Cyclase-Coupled Receptors Guanylate Cyclase Coupled Receptors Guanylyl Cyclase Receptors Cyclase Receptors, Guanylyl Receptors, Guanylyl Cyclase

Below are MeSH descriptors whose meaning is more general than "Receptors, Guanylate Cyclase-Coupled".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Phosphorus-Oxygen Lyases [D08.811.520.650]
Guanylate Cyclase [D08.811.520.650.600]
Receptors, Guanylate Cyclase-Coupled [D08.811.520.650.600.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Guanylate Cyclase-Coupled [D12.776.543.750.700]

Below are MeSH descriptors whose meaning is related to "Receptors, Guanylate Cyclase-Coupled".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Guanylate Cyclase-Coupled".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Guanylate Cyclase-Coupled" by people in this website by year, and whether "Receptors, Guanylate Cyclase-Coupled" was a major or minor topic of these publications.

Bar chart showing 82 publications over 23 distinct years, with a maximum of 11 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	0	1	1
1998	0	2	2
1999	0	1	1
2000	0	2	2
2001	0	3	3
2002	0	3	3
2003	0	1	1
2005	0	5	5
2006	0	5	5
2007	0	4	4
2008	0	6	6
2009	0	11	11
2010	2	2	4
2011	3	1	4
2012	3	0	3
2013	5	0	5
2014	2	2	4
2016	4	1	5
2017	4	1	5
2018	1	0	1
2021	0	2	2
2023	1	1	2

Below are the most recent publications written about "Receptors, Guanylate Cyclase-Coupled" by people in Profiles.

Barton JR, Londregan AK, Alexander TD, Entezari AA, Bar-Ad S, Cheng L, Lepore AC, Snook AE, Covarrubias M, Waldman SA. Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest. 2023 02 15; 133(4).

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Di Guglielmo MD, Holbrook J, Stabley D, Robbins KM, Boyce B, Hardy H, Adeyemi A. The Intestinal Tract Brush Border in Young Children Uniformly Expresses Guanylate Cyclase C. Appl Immunohistochem Mol Morphol. 2023 03 01; 31(3):154-162.

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Weinberg DS, Foster NR, Della'Zanna G, McMurray RP, Kraft WK, Pallotto A, Kastenberg DM, Katz LC, Henry CH, Moleski SM, Limburg PJ, Waldman SA. Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers. Cancer Biol Ther. 2021 12 02; 22(10-12):544-553.

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Flickinger JC, Rappaport JA, Barton JR, Baybutt TR, Pattison AM, Snook AE, Waldman SA. Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomark Med. 2021 Feb; 15(3):201-217.

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Waldman SA, Camilleri M. Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut. 2018 08; 67(8):1543-1552.

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Baybutt TR, Aka AA, Snook AE. The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report. Toxins (Basel). 2017 09 15; 9(9).

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Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017 09 15; 77(18):5095-5106.

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Li P, Lin JE, Snook AE, Waldman SA. ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice. Toxins (Basel). 2017 09 12; 9(9).

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Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol. 2017 May; 10(5):549-557.

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Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE. Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells. J Immunol. 2017 05 01; 198(9):3507-3514.

View in: PubMed

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