Cyclin-Dependent Kinase Inhibitor p21

"Cyclin-Dependent Kinase Inhibitor p21" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.

Descriptor ID	D050759
MeSH Number(s)	D12.644.360.225.500 D12.776.157.687.250 D12.776.167.187.500 D12.776.476.225.500 D12.776.624.776.355.500 D12.776.660.720.250
Concept/Terms	Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 Cyclin Dependent Kinase Inhibitor p21 CDKN1 Protein Senescent Cell-Derived Inhibitor Protein 1 Senescent Cell Derived Inhibitor Protein 1 Cell Cycle Regulator p21 Cyclin-Dependent Kinase Inhibitor 1A Protein Cyclin Dependent Kinase Inhibitor 1A Protein Cyclin Kinase Inhibitor p21 p21 Cyclin Kinase Inhibitor CDKN1A Protein Cdk-Interacting Protein 1 Cdk Interacting Protein 1 Cdk2 Inhibitor Protein CDK2-Associated Protein 20 kDa CDK2 Associated Protein 20 kDa p21 Cell Cycle Regulator

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p21".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.644.360.225.500]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.157.687.250]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.167.187]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.167.187.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.476.225.500]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.624.776.355]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.624.776.355.500]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Cyclin-Dependent Kinase Inhibitor p21 [D12.776.660.720.250]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase Inhibitor p21".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p21".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p21" was a major or minor topic of these publications.

Bar chart showing 38 publications over 14 distinct years, with a maximum of 5 publications in 2002 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2002	0	5	5
2003	0	2	2
2004	0	5	5
2005	1	3	4
2006	0	4	4
2007	0	3	3
2008	0	2	2
2009	2	0	2
2010	0	3	3
2011	1	3	4
2014	0	1	1
2019	1	0	1

Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in Profiles.

Taubenberger AV, Girardo S, Tr?ber N, Fischer-Friedrich E, Kr?ter M, Wagner K, Kurth T, Richter I, Haller B, Binner M, Hahn D, Freudenberg U, Werner C, Guck J. 3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK. Adv Biosyst. 2019 09; 3(9):e1900128.

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Choudhery MS, Badowski M, Muise A, Harris DT. Effect of mild heat stress on the proliferative and differentiative ability of human mesenchymal stromal cells. Cytotherapy. 2015 Apr; 17(4):359-68.

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Bai LY, Chiu CF, Pan SL, Sargeant AM, Shieh TM, Wang YC, Weng JR. Antitumor activity of a novel histone deacetylase inhibitor (S)-HDAC42 in oral squamous cell carcinoma. Oral Oncol. 2011 Dec; 47(12):1127-33.

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Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung. Pediatr Res. 2011 May; 69(5 Pt 1):371-7.

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Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ. Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res. 2011 Apr; 26(4):747-60.

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Javelaud D, van Kempen L, Alexaki VI, Le Scolan E, Luo K, Mauviel A. Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression. Mol Cancer. 2011 Jan 06; 10(1):2.

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Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res. 2010 Nov 1; 70(21):8802-11.

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Abel EV, Aplin AE. FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells. Cancer Res. 2010 Apr 1; 70(7):2891-900.

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Iyer RR, Pluciennik A, Genschel J, Tsai MS, Beese LS, Modrich P. MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. J Biol Chem. 2010 Apr 9; 285(15):11730-9.

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Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S, Ju X, Li Z, Yu Z, Zhou J, Johnson M, Fortina P, Hyslop T, Windle JJ, Pestell RG. p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19035-9.

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