"Protein Kinase C-delta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. Its activity is regulated by a variety of signaling protein tyrosine kinase.
| Descriptor ID |
D051745
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.400
|
| Concept/Terms |
Protein Kinase C-delta- Protein Kinase C-delta
- Kinase C-delta, Protein
- Protein Kinase C delta
- PKC-delta Serine-Threonine Kinase
- PKC delta Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-delta
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-delta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-delta".
This graph shows the total number of publications written about "Protein Kinase C-delta" by people in this website by year, and whether "Protein Kinase C-delta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2006 | 5 | 2 | 7 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 3 | 0 | 3 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C-delta" by people in Profiles.
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Bhavanasi D, Kostyak JC, Swindle J, Kilpatrick LE, Kunapuli SP. CGX1037 is a novel PKC isoform delta selective inhibitor in platelets. Platelets. 2015; 26(1):2-9.
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Wermuth PJ, Addya S, Jimenez SA. Effect of protein kinase C delta (PKC-d) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. PLoS One. 2011; 6(11):e27110.
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Li Z, Jimenez SA. Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. Arthritis Rheum. 2011 Aug; 63(8):2473-83.
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Bhavanasi D, Kim S, Goldfinger LE, Kunapuli SP. Protein kinase Cd mediates the activation of protein kinase D2 in platelets. Biochem Pharmacol. 2011 Oct 01; 82(7):720-7.
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Xiao L, Eto M, Kazanietz MG. ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK. J Biol Chem. 2009 Oct 23; 284(43):29365-75.
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Korzick DH, Kostyak JC, Hunter JC, Saupe KW. Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation. . 2007 Oct; 293(4):H2056-63.
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Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res. 2006 Dec 15; 66(24):11792-801.
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Hunter JC, Kostyak JC, Novotny JL, Simpson AM, Korzick DH. Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. . 2007 Feb; 292(2):R800-9.
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Riobo NA, Lu K, Emerson CP. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle. 2006 Aug; 5(15):1612-5.
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Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U. EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities. Cancer Biol Ther. 2006 May; 5(5):498-504.