Protein Kinase C

"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

Descriptor ID	D011493
MeSH Number(s)	D08.811.913.696.620.682.700.725
Concept/Terms	Protein Kinase C Protein Kinase C Calcium-Activated Phospholipid-Dependent Kinase Calcium Activated Phospholipid Dependent Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine-Threonine Kinase PKC Serine Threonine Kinase Serine-Threonine Kinase, PKC Calcium Phospholipid-Dependent Protein Kinase Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Phospholipid Sensitive Calcium Dependent Protein Kinase Protein Kinase M Protein Kinase M

Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Protein Kinase C [D08.811.913.696.620.682.700.725]

Below are MeSH descriptors whose meaning is related to "Protein Kinase C".

Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.

Bar chart showing 130 publications over 24 distinct years, with a maximum of 12 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	7	1	8
1996	3	3	6
1997	2	3	5
1998	3	3	6
1999	4	2	6
2000	3	1	4
2001	4	4	8
2002	8	4	12
2003	2	4	6
2004	6	2	8
2005	5	5	10
2006	1	5	6
2007	4	4	8
2008	4	5	9
2009	1	0	1
2010	4	5	9
2011	2	2	4
2012	1	5	6
2013	3	0	3
2014	1	0	1
2015	1	0	1
2017	1	0	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Protein Kinase C" by people in Profiles.

Hernandez-Lara MA, Richard J, Deshpande DA. Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma. Am J Physiol Lung Cell Mol Physiol. 2024 Jul 01; 327(1):L3-L18.

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Eto M, Katsuki S, Ohashi M, Miyagawa Y, Tanaka Y, Takeya K, Kitazawa T. Possible roles of N- and C-terminal unstructured tails of CPI-17 in regulating Ca2+ sensitization force of smooth muscle. J Smooth Muscle Res. 2022; 58(0):22-33.

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Luo J, Busillo JM, Stumm R, Benovic JL. G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin. Mol Pharmacol. 2017 Jun; 91(6):554-566.

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Khan TK, Sen A, Hongpaisan J, Lim CS, Nelson TJ, Alkon DL. PKCe deficits in Alzheimer's disease brains and skin fibroblasts. J Alzheimers Dis. 2015; 43(2):491-509.

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Kostyak JC, Kunapuli SP. PKC? is dispensable for megakaryopoiesis. Platelets. 2015; 26(6):610-1.

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Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser ZJ, Alkon DL, Rosen CL, Huber JD. Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke. Stroke. 2013 Dec; 44(12):3490-7.

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Hongpaisan J, Xu C, Sen A, Nelson TJ, Alkon DL. PKC activation during training restores mushroom spine synapses and memory in the aged rat. Neurobiol Dis. 2013 Jul; 55:44-62.

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Manterola L, Hernando-Rodr?guez M, Ruiz A, Apraiz A, Arrizabalaga O, Vell?n L, Alberdi E, Cavaliere F, Lacerda HM, Jimenez S, Parada LA, Matute C, Zugaza JL. 1-42 ?-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death. Transl Psychiatry. 2013 Jan 22; 3:e219.

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Lucas CR, Cordero-Nieves HM, Erbe RS, McAlees JW, Bhatia S, Hodes RJ, Campbell KS, Sanders VM. Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. J Immunol. 2013 Jan 15; 190(2):723-36.

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Harleton E, Besana A, Comas GM, Danilo P, Rosen TS, Argenziano M, Rosen MR, Robinson RB, Feinmark SJ. Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). J Biol Chem. 2013 Jan 25; 288(4):2829-38.

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