Below are the most recent publications written about "Aggrecans" by people in Profiles.
-
Novais EJ, Tran VA, Johnston SN, Darris KR, Roupas AJ, Sessions GA, Shapiro IM, Diekman BO, Risbud MV. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021 09 03; 12(1):5213.
-
Hoshijima M, Hattori T, Aoyama E, Nishida T, Kubota S, Kamioka H, Takigawa M. Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes. Int J Mol Sci. 2020 Apr 16; 21(8).
-
Brescia AC, Simonds MM, McCahan SM, Fawcett PT, Rose CD. The role of transforming growth factor ? signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor ? signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy. Arthritis Rheumatol. 2014 May; 66(5):1352-62.
-
Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV. TNF-a and IL-1ß promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem. 2011 Nov 18; 286(46):39738-49.
-
Cheng CC, Uchiyama Y, Hiyama A, Gajghate S, Shapiro IM, Risbud MV. PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc. J Cell Physiol. 2009 Dec; 221(3):668-76.
-
Smith SM, Whitelock JM, Iozzo RV, Little CB, Melrose J. Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochem Cell Biol. 2009 Nov; 132(5):491-503.
-
Sowa G, Westrick E, Rajasekhar AG, Woods B, Leckie S, Coelho P, Vo N, Studer R, Kang J. Identification of candidate serum biomarkers for intervertebral disk degeneration in an animal model. PM R. 2009 Jun; 1(6):536-40.
-
Zhang Y, Markova D, Im HJ, Hu W, Thonar EJ, He TC, An HS, Phillips FM, Anderson DG. Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype. Am J Phys Med Rehabil. 2009 Jun; 88(6):455-63.
-
Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M. N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan. Biochem J. 2009 May 27; 420(3):413-20.
-
Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009 Apr 15; 328(2):315-27.