CCN Intercellular Signaling Proteins

"CCN Intercellular Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.

Descriptor ID	D055511
MeSH Number(s)	D12.644.276.200 D12.776.467.200 D12.776.860.300.200 D23.529.237
Concept/Terms	CCN Intercellular Signaling Proteins CCN Intercellular Signaling Proteins Matricellular CCN Proteins CCN Family Proteins CYR61 CTGF NOV Matricellular Proteins

Below are MeSH descriptors whose meaning is more general than "CCN Intercellular Signaling Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
CCN Intercellular Signaling Proteins [D12.644.276.200]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
CCN Intercellular Signaling Proteins [D12.776.467.200]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
CCN Intercellular Signaling Proteins [D12.776.860.300.200]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
CCN Intercellular Signaling Proteins [D23.529.237]

Below are MeSH descriptors whose meaning is related to "CCN Intercellular Signaling Proteins".

Below are MeSH descriptors whose meaning is more specific than "CCN Intercellular Signaling Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CCN Intercellular Signaling Proteins" by people in this website by year, and whether "CCN Intercellular Signaling Proteins" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 3 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	1	1
2007	0	1	1
2009	0	1	1
2015	1	0	1
2017	3	0	3
2020	1	0	1

Below are the most recent publications written about "CCN Intercellular Signaling Proteins" by people in Profiles.

Hsu GC, Marini S, Negri S, Wang Y, Xu J, Pagani C, Hwang C, Stepien D, Meyers CA, Miller S, McCarthy E, Lyons KM, Levi B, James AW. Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification. JCI Insight. 2020 07 09; 5(13).

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Jiang J, Hu Z, Lyons KM. Design and Analysis of CCN Gene Activity Using CCN Knockout Mice Containing LacZ Reporters. Methods Mol Biol. 2017; 1489:325-345.

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Kubota S, Takigawa M. Preparation of Module-Specific Antibodies Against CCN Family Members. Methods Mol Biol. 2017; 1489:115-126.

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Nishida T, Kubota S, Takigawa M. Production of Recombinant CCN2 Protein by Mammalian Cells. Methods Mol Biol. 2017; 1489:95-105.

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Maeda A, Ono M, Holmbeck K, Li L, Kilts TM, Kram V, Noonan ML, Yoshioka Y, McNerny EM, Tantillo MA, Kohn DH, Lyons KM, Robey PG, Young MF. WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem. 2015 May 29; 290(22):14004-18.

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K?nigshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, Jahn A, Rose F, Fink L, Seeger W, Schaefer L, G?nther A, Eickelberg O. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 2009 Apr; 119(4):772-87.

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Yanagita T, Kubota S, Kawaki H, Kawata K, Kondo S, Takano-Yamamoto T, Tanaka S, Takigawa M. Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J. 2007 Apr; 274(7):1655-65.

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Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF, Livant D, Merajver SD. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene. 2002 May 09; 21(20):3172-80.

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van Golen KL, Davies S, Wu ZF, Wang Y, Bucana CD, Root H, Chandrasekharappa S, Strawderman M, Ethier SP, Merajver SD. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res. 1999 Sep; 5(9):2511-9.

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