Transforming Growth Factor beta2

"Transforming Growth Factor beta2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.

Descriptor ID	D053781
MeSH Number(s)	D12.644.276.374.687.200 D12.644.276.954.775.200 D12.776.467.374.687.200 D12.776.467.942.775.200 D23.529.374.687.200 D23.529.942.775.200
Concept/Terms	Transforming Growth Factor beta2 Transforming Growth Factor beta2 Glioblastoma-Derived T-Cell Suppressor Factor Glioblastoma Derived T Cell Suppressor Factor Cartilage-Inducing Factor-B Cartilage Inducing Factor B Polyergin TGF-beta2 TGF-beta-2 BSC-1 Cell Growth Inhibitor BSC 1 Cell Growth Inhibitor Suppressor Factor, T-Cell, Glioblastoma-Derived Transforming Growth Factor beta 2 Latency Associated Peptide Transforming Growth Factor beta 2 Latency Associated Peptide TGF-beta2LAP TGF beta2LAP TGF-beta2 Latency-Associated Protein Latency-Associated Protein, TGF-beta2 TGF beta2 Latency Associated Protein

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
Transforming Growth Factor beta2 [D12.644.276.374.687.200]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Transforming Growth Factor beta2 [D12.644.276.954.775.200]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
Transforming Growth Factor beta2 [D12.776.467.374.687.200]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Transforming Growth Factor beta2 [D12.776.467.942.775.200]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
Transforming Growth Factor beta2 [D23.529.374.687.200]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]
Transforming Growth Factor beta2 [D23.529.942.775.200]

Below are MeSH descriptors whose meaning is related to "Transforming Growth Factor beta2".

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta2" by people in this website by year, and whether "Transforming Growth Factor beta2" was a major or minor topic of these publications.

Bar chart showing 10 publications over 10 distinct years, with a maximum of 1 publications in 2001 and 2003 and 2006 and 2007 and 2009 and 2013 and 2014 and 2015 and 2021 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2003	0	1	1
2006	0	1	1
2007	1	0	1
2009	0	1	1
2013	1	0	1
2014	0	1	1
2015	0	1	1
2021	1	0	1
2024	1	0	1

Below are the most recent publications written about "Transforming Growth Factor beta2" by people in Profiles.

Quintanilha JCF, Sibley AB, Liu Y, Niedzwiecki D, Halabi S, Rogers L, O'Neil B, Kindler H, Kelly W, Venook A, McLeod HL, Ratain MJ, Nixon AB, Innocenti F, Owzar K. Common variation in a long non-coding RNA gene modulates variation of circulating TGF-?2 levels in metastatic colorectal cancer patients (Alliance). BMC Genomics. 2024 May 14; 25(1):473.

View in: PubMed
Schneider M, Dillinger AE, Ohlmann A, Iozzo RV, Fuchshofer R. Decorin-An Antagonist of TGF-ß in Astrocytes of the Optic Nerve. Int J Mol Sci. 2021 Jul 17; 22(14).

View in: PubMed
Thalji NM, Hagler MA, Zhang H, Casaclang-Verzosa G, Nair AA, Suri RM, Miller JD. Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease. Circ Cardiovasc Genet. 2015 Jun; 8(3):516-28.

View in: PubMed
Chatterjee A, Villarreal G, Oh DJ, Kang MH, Rhee DJ. AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork. Invest Ophthalmol Vis Sci. 2014 Apr 08; 55(5):3127-39.

View in: PubMed
Mony S, Lee SJ, Harper JF, Barwe SP, Langhans SA. Regulation of Na,K-ATPase ?1-subunit in TGF-?2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells. Exp Eye Res. 2013 Oct; 115:113-22.

View in: PubMed
Yu M, Smolen GA, Zhang J, Wittner B, Schott BJ, Brachtel E, Ramaswamy S, Maheswaran S, Haber DA. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 2009 Aug 01; 23(15):1737-42.

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Singh B, Murphy RF, Ding XZ, Roginsky AB, Bell RH, Adrian TE. On the role of transforming growth factor-beta in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells. Mol Cancer. 2007 Dec 24; 6:82.

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McCauley TG, Kurz JC, Merlino PG, Lewis SD, Gilbert M, Epstein DM, Marsh HN. Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor. Pharm Res. 2006 Feb; 23(2):303-11.

View in: PubMed
Sharma K, Deelman L, Madesh M, Kurz B, Ciccone E, Siva S, Hu T, Zhu Y, Wang L, Henning R, Ma X, Hajnoczky G. Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1258-70.

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Bellone G, Carbone A, Tibaudi D, Mauri F, Ferrero I, Smirne C, Suman F, Rivetti C, Migliaretti G, Camandona M, Palestro G, Emanuelli G, Rodeck U. Differential expression of transforming growth factors-beta1, -beta2 and -beta3 in human colon carcinoma. Eur J Cancer. 2001 Jan; 37(2):224-33.

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