HIV Reverse Transcriptase
"HIV Reverse Transcriptase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
| Descriptor ID |
D054303
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| MeSH Number(s) |
D08.811.913.696.445.308.300.750.187 D12.776.964.775.375.545.875 D12.776.964.775.375.750.187 D12.776.964.775.562.764.875 D12.776.964.970.600.850.375.545.875 D12.776.964.970.600.850.375.750.187
|
| Concept/Terms |
HIV Reverse Transcriptase- HIV Reverse Transcriptase
- Transcriptase, HIV Reverse
- Reverse Transcriptase, Human Immunodeficiency Virus
- Reverse Transcriptase, HIV
|
Below are MeSH descriptors whose meaning is more general than "HIV Reverse Transcriptase".
Below are MeSH descriptors whose meaning is more specific than "HIV Reverse Transcriptase".
This graph shows the total number of publications written about "HIV Reverse Transcriptase" by people in this website by year, and whether "HIV Reverse Transcriptase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "HIV Reverse Transcriptase" by people in Profiles.
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Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96.
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Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog. 2011 May; 7(5):e1002038.
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Jordan PS, Poon A, Eron J, Squires K, Ignacio C, Richman DD, Smith DM. A novel codon insert in protease of clade B HIV type 1. AIDS Res Hum Retroviruses. 2009 May; 25(5):547-50.
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Elworthy TR, Dunn JP, Hogg JH, Lam G, Saito YD, Silva TM, Stefanidis D, Woroniecki W, Zhornisky E, Zhou AS, Klumpp K. Orally bioavailable prodrugs of a BCS class 2 molecule, an inhibitor of HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6344-7.
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Sweeney ZK, Dunn JP, Li Y, Heilek G, Dunten P, Elworthy TR, Han X, Harris SF, Hirschfeld DR, Hogg JH, Huber W, Kaiser AC, Kertesz DJ, Kim W, Mirzadegan T, Roepel MG, Saito YD, Silva TM, Swallow S, Tracy JL, Villasenor A, Vora H, Zhou AS, Klumpp K. Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 2008 Aug 01; 18(15):4352-4.
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Mehanna AS, Belani JD, Kelley CJ, Pallansc LA. Design, synthesis and biological evaluation of a series of thioamides as non-nucleoside reverse transcriptase inhibitors. Med Chem. 2007 Nov; 3(6):513-9.
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Romano L, Venturi G, Bloor S, Harrigan R, Larder BA, Major JC, Zazzi M. Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118. J Infect Dis. 2002 Apr 1; 185(7):898-904.