DNA-Directed DNA Polymerase

"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.

Descriptor ID	D004259
MeSH Number(s)	D08.811.913.696.445.308.300
Concept/Terms	DNA-Directed DNA Polymerase DNA-Directed DNA Polymerase DNA Directed DNA Polymerase DNA Polymerase, DNA-Directed Polymerase, DNA-Directed DNA DNA-Dependent DNA Polymerases DNA Dependent DNA Polymerases DNA Polymerases, DNA-Dependent Polymerases, DNA-Dependent DNA DNA Polymerases Polymerases, DNA DNA Polymerase N3 DNA Polymerase N3 Polymerase N3, DNA

Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
DNA Nucleotidyltransferases [D08.811.913.696.445.308]
DNA-Directed DNA Polymerase [D08.811.913.696.445.308.300]

Below are MeSH descriptors whose meaning is related to "DNA-Directed DNA Polymerase".

Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.

Bar chart showing 43 publications over 22 distinct years, with a maximum of 5 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	2	2
2002	0	2	2
2003	1	0	1
2004	0	2	2
2005	0	1	1
2006	0	1	1
2007	0	1	1
2008	1	1	2
2009	3	0	3
2010	1	2	3
2011	1	1	2
2013	0	1	1
2015	1	0	1
2016	4	1	5
2017	1	0	1
2018	1	0	1
2019	2	0	2
2020	1	0	1
2021	4	0	4
2023	1	1	2
2024	2	2	4

Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.

Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT. Structural basis for a Pol? helicase small-molecule inhibitor revealed by cryo-EM. Nat Commun. 2024 08 14; 15(1):7003.

View in: PubMed
Lin X, Soni A, Hessenow R, Sun Y, Mladenov E, Guberina M, Stuschke M, Iliakis G. Talazoparib enhances resection at DSBs and renders HR-proficient cancer cells susceptible to Pol? inhibition. Radiother Oncol. 2024 11; 200:110475.

View in: PubMed
Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, Atkins J, Ralph D, Nieborowska-Skorska M, Kukuyan AM, Tang HY, Pomerantz RT, Skorski T. PARG is essential for Pol?-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nat Commun. 2024 07 11; 15(1):5822.

View in: PubMed
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Discovery of a small-molecule inhibitor that traps Pol? on DNA and synergizes with PARP inhibitors. Nat Commun. 2024 Apr 05; 15(1):2862.

View in: PubMed
Buchel G, Nayak AR, Herbine K, Sarfallah A, Sokolova VO, Zamudio-Ochoa A, Temiakov D. Structural basis for DNA proofreading. Nat Commun. 2023 12 27; 14(1):8501.

View in: PubMed
Vandenberg BN, Laughery MF, Cordero C, Plummer D, Mitchell D, Kreyenhagen J, Albaqshi F, Brown AJ, Mieczkowski PA, Wyrick JJ, Roberts SA. Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts. Nat Commun. 2023 05 04; 14(1):2576.

View in: PubMed
Shen S, Davidson GA, Yang K, Zhuang Z. Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Pol?/PCNA complex. Nucleic Acids Res. 2021 09 20; 49(16):9374-9388.

View in: PubMed
Chen XS, Pomerantz RT. DNA Polymerase ?: A Cancer Drug Target with Reverse Transcriptase Activity. Genes (Basel). 2021 07 27; 12(8).

View in: PubMed
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, Treddinick T, Lopezcolorado FW, Kent T, Siddique LA, Mallon J, Huhn J, Shoda Z, Kashkina E, Brambati A, Stark JM, Chen XS, Pomerantz RT. Pol? reverse transcribes RNA and promotes RNA-templated DNA repair. Sci Adv. 2021 06; 7(24).

View in: PubMed
Chandramouly G, Liao S, Rusanov T, Borisonnik N, Calbert ML, Kent T, Sullivan-Reed K, Vekariya U, Kashkina E, Skorski T, Yan H, Pomerantz RT. Pol? promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining. Cell Rep. 2021 03 09; 34(10):108820.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement