RNA-Directed DNA Polymerase
"RNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.
| Descriptor ID |
D012194
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.750 D12.776.964.775.375.750 D12.776.964.970.600.850.375.750
|
| Concept/Terms |
RNA-Directed DNA Polymerase- RNA-Directed DNA Polymerase
- RNA Directed DNA Polymerase
- Reverse Transcriptase
- RNA Transcriptase
- DNA Polymerase, RNA-Directed
- DNA Polymerase, RNA Directed
- RNA-Dependent DNA Polymerase
- DNA Polymerase, RNA-Dependent
- RNA Dependent DNA Polymerase
- Revertase
|
Below are MeSH descriptors whose meaning is more general than "RNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "RNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "RNA-Directed DNA Polymerase" by people in this website by year, and whether "RNA-Directed DNA Polymerase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 3 | 3 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "RNA-Directed DNA Polymerase" by people in Profiles.
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Chen XS, Pomerantz RT. DNA Polymerase ?: A Cancer Drug Target with Reverse Transcriptase Activity. Genes (Basel). 2021 07 27; 12(8).
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Holinstat M. New LINE(s) of Evidence for Genetic Regulation of Platelets. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):690-691.
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Yamani LN, Yano Y, Utsumi T, Wasityastuti W, Rinonce HT, Widasari DI, Lusida MI, Hayashi Y. Profile of Mutations in the Reverse Transcriptase and Overlapping Surface Genes of Hepatitis B Virus (HBV) in Treatment-Naïve Indonesian HBV Carriers. Jpn J Infect Dis. 2017 Nov 22; 70(6):647-655.
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Wasityastuti W, Yano Y, Widasari DI, Yamani LN, Ratnasari N, Heriyanto DS, Okada R, Tanahashi T, Murakami Y, Azuma T, Hayashi Y. Different Variants in Reverse Transcriptase Domain Determined by Ultra-deep Sequencing in Treatment-na?ve and Treated Indonesian Patients Infected with Hepatitis B Virus. Kobe J Med Sci. 2016 Jun 16; 62(1):E1-8.
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Widasari DI, Yano Y, Heriyanto DS, Utsumi T, Yamani LN, Rinonce HT, Wasityastuti W, Lusida MI, Okada R, Murakami Y, Tanahashi T, Azuma T, Hayashi Y. A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians. Intervirology. 2014; 57(6):384-92.
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Jones SA, Murakami E, Delaney W, Furman P, Hu J. Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine. Antimicrob Agents Chemother. 2013 Sep; 57(9):4181-9.
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Tonini T, Claudio PP, Giordano A, Romano G. Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase. Methods Mol Biol. 2004; 285:155-7.
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Delaney WE, Yang H, Westland CE, Das K, Arnold E, Gibbs CS, Miller MD, Xiong S. The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J Virol. 2003 Nov; 77(21):11833-41.
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Argyris EG, Vanderkooi JM, Venkateswaran PS, Kay BK, Paterson Y. The connection domain is implicated in metalloporphyrin binding and inhibition of HIV reverse transcriptase. J Biol Chem. 1999 Jan 15; 274(3):1549-56.
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Waldman SA, Barber M, Pearlman J, Park J, George R, Parkinson SJ. Heterogeneity of guanylyl cyclase C expressed by human colorectal cancer cell lines in vitro. Cancer Epidemiol Biomarkers Prev. 1998 Jun; 7(6):505-14.