"Bryostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of 20-member macrolactones in which there are three remotely substituted pyran rings that are linked by a methylene bridge and an E-disubstituted alkene, and have geminal dimethyls at C8 and C18 carbons. Some interact with PROTEIN KINASE C.
| Descriptor ID |
D054713
|
| MeSH Number(s) |
D02.540.576.500.937
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Bryostatins".
Below are MeSH descriptors whose meaning is more specific than "Bryostatins".
This graph shows the total number of publications written about "Bryostatins" by people in this website by year, and whether "Bryostatins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Bryostatins" by people in Profiles.
-
Gamlen HA, Romer-Seibert JS, Lawler ME, Versace AM, Goetz ML, Feng Y, Guryanova OA, Palmisiano N, Meyer SE. miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML. Clin Cancer Res. 2022 10 14; 28(20):4574-4586.
-
Wu WC, Tian J, Xiao D, Guo YX, Xiao Y, Wu XY, Casella G, Rasouli J, Yan YP, Rostami A, Wang LB, Zhang Y, Li X. Engineered extracellular vesicles encapsulated Bryostatin-1 as therapy for neuroinflammation. Nanoscale. 2022 Feb 10; 14(6):2393-2410.
-
Alkon DL, Hongpaisan J, Sun MK. Effects of chronic bryostatin-1 on treatment-resistant depression in rats. Eur J Pharmacol. 2017 Jul 15; 807:71-74.
-
Sen A, Hongpaisan J, Wang D, Nelson TJ, Alkon DL. Protein Kinase C? (PKC?) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95. J Biol Chem. 2016 08 05; 291(32):16462-76.
-
Sun MK, Hongpaisan J, Alkon DL. Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice. J Pharmacol Exp Ther. 2016 May; 357(2):300-10.
-
Sun MK, Hongpaisan J, Lim CS, Alkon DL. Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile x mice. J Pharmacol Exp Ther. 2014 Jun; 349(3):393-401.
-
Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser ZJ, Alkon DL, Rosen CL, Huber JD. Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke. Stroke. 2013 Dec; 44(12):3490-7.
-
Hongpaisan J, Xu C, Sen A, Nelson TJ, Alkon DL. PKC activation during training restores mushroom spine synapses and memory in the aged rat. Neurobiol Dis. 2013 Jul; 55:44-62.
-
Hongpaisan J, Sun MK, Alkon DL. PKC e activation prevents synaptic loss, Aß elevation, and cognitive deficits in Alzheimer's disease transgenic mice. J Neurosci. 2011 Jan 12; 31(2):630-43.
-
Zohar O, Lavy R, Zi X, Nelson TJ, Hongpaisan J, Pick CG, Alkon DL. PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiol Dis. 2011 Feb; 41(2):329-37.