Connective Tissue Growth Factor

"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Descriptor ID	D055513
MeSH Number(s)	D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
Concept/Terms	Connective Tissue Growth Factor Connective Tissue Growth Factor Hypertrophic Chondrocyte-Specific Protein 24 Hypertrophic Chondrocyte Specific Protein 24 IGF-Binding Protein-Related Protein-2 IGF Binding Protein Related Protein 2 IGFBP-rP2 Insulin-Like Growth Factor Binding Protein 8 Insulin Like Growth Factor Binding Protein 8 CCN2 Protein IGFBP-8

Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
CCN Intercellular Signaling Proteins [D12.644.276.200]
Connective Tissue Growth Factor [D12.644.276.200.100]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
CCN Intercellular Signaling Proteins [D12.776.467.200]
Connective Tissue Growth Factor [D12.776.467.200.100]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
CCN Intercellular Signaling Proteins [D12.776.860.300.200]
Connective Tissue Growth Factor [D12.776.860.300.200.100]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
CCN Intercellular Signaling Proteins [D23.529.237]
Connective Tissue Growth Factor [D23.529.237.100]

Below are MeSH descriptors whose meaning is related to "Connective Tissue Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	1	1
2004	0	2	2
2006	0	2	2
2009	1	0	1
2010	2	1	3
2011	1	1	2
2012	1	0	1
2013	1	0	1
2021	1	0	1

Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.

Tam AYY, Horwell AL, Trinder SL, Khan K, Xu S, Ong V, Denton CP, Norman JT, Holmes AM, Bou-Gharios G, Abraham DJ. Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension. Int J Biochem Cell Biol. 2021 05; 134:105961.

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Sonnylal S, Xu S, Jones H, Tam A, Sreeram VR, Ponticos M, Norman J, Agrawal P, Abraham D, de Crombrugghe B. Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci. 2013 May 15; 126(Pt 10):2164-75.

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Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG, Martinez-Outschoorn U, Lisanti MP, Sotgia F. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle. 2012 Jun 15; 11(12):2272-84.

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Tong Z, Sant S, Khademhosseini A, Jia X. Controlling the fibroblastic differentiation of mesenchymal stem cells via the combination of fibrous scaffolds and connective tissue growth factor. Tissue Eng Part A. 2011 Nov; 17(21-22):2773-85.

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Liu S, Shi-wen X, Abraham DJ, Leask A. CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum. 2011 Jan; 63(1):239-46.

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Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci. 2010 Nov 1; 123(Pt 21):3674-82.

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Tran CM, Markova D, Smith HE, Susarla B, Ponnappan RK, Anderson DG, Symes A, Shapiro IM, Risbud MV. Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis Rheum. 2010 Jul; 62(7):1983-92.

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Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B. Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum. 2010 May; 62(5):1523-32.

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Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 2009 Jul; 60(7):2142-55.

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Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res. 2007 Mar 10; 313(5):952-64.

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