Connective Tissue Growth Factor

"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Descriptor ID	D055513
MeSH Number(s)	D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
Concept/Terms	Connective Tissue Growth Factor Connective Tissue Growth Factor Hypertrophic Chondrocyte-Specific Protein 24 Hypertrophic Chondrocyte Specific Protein 24 IGF-Binding Protein-Related Protein-2 IGF Binding Protein Related Protein 2 IGFBP-rP2 Insulin-Like Growth Factor Binding Protein 8 Insulin Like Growth Factor Binding Protein 8 CCN2 Protein IGFBP-8

Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
CCN Intercellular Signaling Proteins [D12.644.276.200]
Connective Tissue Growth Factor [D12.644.276.200.100]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
CCN Intercellular Signaling Proteins [D12.776.467.200]
Connective Tissue Growth Factor [D12.776.467.200.100]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
CCN Intercellular Signaling Proteins [D12.776.860.300.200]
Connective Tissue Growth Factor [D12.776.860.300.200.100]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
CCN Intercellular Signaling Proteins [D23.529.237]
Connective Tissue Growth Factor [D23.529.237.100]

Below are MeSH descriptors whose meaning is related to "Connective Tissue Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.

Bar chart showing 55 publications over 20 distinct years, with a maximum of 7 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	2	2
2003	0	1	1
2004	0	4	4
2005	0	1	1
2006	0	2	2
2007	0	4	4
2008	3	3	6
2009	4	1	5
2010	3	1	4
2011	6	1	7
2012	3	1	4
2013	2	0	2
2014	3	0	3
2015	1	0	1
2016	0	1	1
2017	0	3	3
2020	2	0	2
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.

Glueck M, Koch A, Brunkhorst R, Ferreiros Bouzas N, Trautmann S, Schaefer L, Pfeilschifter W, Pfeilschifter J, Vutukuri R. The atypical sphingosine 1-phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma. FEBS J. 2022 09; 289(18):5670-5681.

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Tam AYY, Horwell AL, Trinder SL, Khan K, Xu S, Ong V, Denton CP, Norman JT, Holmes AM, Bou-Gharios G, Abraham DJ. Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension. Int J Biochem Cell Biol. 2021 05; 134:105961.

View in: PubMed
Ohkawara B, Kobayakawa A, Kanbara S, Hattori T, Kubota S, Ito M, Masuda A, Takigawa M, Lyons KM, Ishiguro N, Ohno K. CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction. EMBO Rep. 2020 08 05; 21(8):e48462.

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Hoshijima M, Hattori T, Aoyama E, Nishida T, Kubota S, Kamioka H, Takigawa M. Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes. Int J Mol Sci. 2020 Apr 16; 21(8).

View in: PubMed
Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J. Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. Am J Pathol. 2017 Nov; 187(11):2413-2429.

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Rawal S, Munasinghe PE, Nagesh PT, Lew JKS, Jones GT, Williams MJA, Davis P, Bunton D, Galvin IF, Manning P, Lamberts RR, Katare R. Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type?2 diabetic human and mouse heart. Clin Sci (Lond). 2017 May 01; 131(9):847-863.

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Klinkhammer BM, Goldschmeding R, Floege J, Boor P. Treatment of Renal Fibrosis-Turning Challenges into Opportunities. Adv Chronic Kidney Dis. 2017 03; 24(2):117-129.

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Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D. TGF? and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016 Mar; 12(3):e1005936.

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Murase Y, Hattori T, Aoyama E, Nishida T, Maeda-Uematsu A, Kawaki H, Lyons KM, Sasaki A, Takigawa M, Kubota S. Role of CCN2 in Amino Acid Metabolism of Chondrocytes. J Cell Biochem. 2016 Apr; 117(4):927-37.

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Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M. CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. J Biochem. 2015 Feb; 157(2):91-100.

View in: PubMed

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