Cell Cycle Checkpoints

"Cell Cycle Checkpoints" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.

Descriptor ID	D059447
MeSH Number(s)	G04.144.109
Concept/Terms	Cell Cycle Checkpoints Cell Cycle Checkpoints Cell Cycle Checkpoint Checkpoint, Cell Cycle Checkpoints, Cell Cycle Cell Cycle Transition Points Cell Cycle Transition Points Cell Cycle-Transition Points Cell Cycle-Transition Point Cycle-Transition Point, Cell Point, Cell Cycle-Transition Cell Cycle Arrest Cell Cycle Arrest Arrest, Cell Cycle Arrests, Cell Cycle Cell Cycle Arrests Cell Cycle Control Cell Cycle Control Cell Cycle Controls Control, Cell Cycle Controls, Cell Cycle

Below are MeSH descriptors whose meaning is more general than "Cell Cycle Checkpoints".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Cycle [G04.144]
Cell Cycle Checkpoints [G04.144.109]

Below are MeSH descriptors whose meaning is related to "Cell Cycle Checkpoints".

Below are MeSH descriptors whose meaning is more specific than "Cell Cycle Checkpoints".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cell Cycle Checkpoints" by people in this website by year, and whether "Cell Cycle Checkpoints" was a major or minor topic of these publications.

Bar chart showing 23 publications over 10 distinct years, with a maximum of 5 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2012	0	3	3
2013	0	4	4
2014	0	2	2
2016	1	1	2
2017	1	4	5
2018	1	0	1
2020	0	1	1
2021	0	2	2
2022	0	2	2
2024	1	0	1

Below are the most recent publications written about "Cell Cycle Checkpoints" by people in Profiles.

Desai V, Tadinada SM, Shaghaghi H, Summer R, Lai JCK, Bhushan A. Combination Treatment of Biochanin A and Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism and Inducing Cell Cycle Arrest in Pancreatic Cancer Cells. Anticancer Res. 2024 Jun; 44(6):2307-2323.

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Kumar S, Mulchandani V, Das Sarma J. Methanolic neem (Azadirachta indica) stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells in vitro. BMC Complement Med Ther. 2022 Sep 10; 22(1):239.

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Chandramouly G. Gadd45 in DNA Demethylation and DNA Repair. Adv Exp Med Biol. 2022; 1360:55-67.

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Alam A, Jamil AK, Van Zyl JS, Medel-Martinez H, Bottiglieri T, Wasek B, Felius J, Lima B, Hall SA, Joseph SM. Urinary Cell-Cycle Arrest Biomarkers as Early Predictors of Acute Kidney Injury After Ventricular Assist Device Implantation or Cardiac Transplantation. J Cardiothorac Vasc Anesth. 2022 08; 36(8 Pt A):2303-2312.

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Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nat Commun. 2021 01 20; 12(1):484.

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Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nat Commun. 2020 08 10; 11(1):3987.

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Mills CC, Kolb EA, Sampson VB. Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and Pediatric Cancer Therapy. Cancer Res. 2018 01 15; 78(2):320-325.

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Mills CC, Kolb EA, Sampson VB. Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer. Cancer Res. 2017 12 01; 77(23):6489-6498.

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Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017 07 28; 357(6349):409-413.

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Feeley KP, Adams CM, Mitra R, Eischen CM. Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. Cancer Res. 2017 07 15; 77(14):3823-3833.

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