Polycomb Repressive Complex 1
"Polycomb Repressive Complex 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063150
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| MeSH Number(s) |
D05.500.781.100 D08.811.464.938.750.280 D12.776.660.235.600.100 D12.776.664.235.800.100 D12.776.930.780.890.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 1".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 1".
This graph shows the total number of publications written about "Polycomb Repressive Complex 1" by people in this website by year, and whether "Polycomb Repressive Complex 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
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Below are the most recent publications written about "Polycomb Repressive Complex 1" by people in Profiles.
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Marchesi I, Giordano A, Bagella L. Roles of enhancer of zeste homolog 2: from skeletal muscle differentiation to rhabdomyosarcoma carcinogenesis. Cell Cycle. 2014; 13(4):516-27.
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Rajabpour FV, Raoofian R, Youssefian L, Vahidnezhad H, Shahshahani MM, Fathi H, Noormohammadpour P, Hesari KK, Hashemzadeh-Chaleshtori M, Tabrizi M. BMI1 and TWIST1 downregulated mRNA expression in basal cell carcinoma. Asian Pac J Cancer Prev. 2014; 15(8):3797-800.
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Basu A, Wilkinson FH, Colavita K, Fennelly C, Atchison ML. YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. Nucleic Acids Res. 2014 Feb; 42(4):2208-23.
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Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell. 2012 Aug 31; 150(5):922-33.
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Wilkinson F, Pratt H, Atchison ML. PcG recruitment by the YY1 REPO domain can be mediated by Yaf2. J Cell Biochem. 2010 Feb 15; 109(3):478-86.
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Bhattacharya R, Nicoloso M, Arvizo R, Wang E, Cortez A, Rossi S, Calin GA, Mukherjee P. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res. 2009 Dec 1; 69(23):9090-5.
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Petruk S, Smith ST, Sedkov Y, Mazo A. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development. 2008 Aug; 135(14):2383-90.
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Wilkinson FH, Park K, Atchison ML. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19296-301.
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Atchison L, Ghias A, Wilkinson F, Bonini N, Atchison ML. Transcription factor YY1 functions as a PcG protein in vivo. EMBO J. 2003 Mar 17; 22(6):1347-58.