Ubiquitin-Protein Ligases

"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Descriptor ID	D044767
MeSH Number(s)	D08.811.464.938.750
Concept/Terms	Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases Ligases, Ubiquitin-Protein Ubiquitin Protein Ligases E3 Ubiquitin Ligase Ligase, E3 Ubiquitin Ubiquitin Ligase, E3 Ubiquitin-Protein Ligase E3 Ligase E3, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ubiquitin Ligase E3 Ligase E3, Ubiquitin Ubiquitin-Protein Ligase Ligase, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ligase Ligase, E3

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Protein Ligases".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.

Bar chart showing 48 publications over 22 distinct years, with a maximum of 5 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2000	0	1	1
2002	0	1	1
2003	3	0	3
2004	1	0	1
2005	0	2	2
2006	1	0	1
2007	2	1	3
2008	1	1	2
2010	1	2	3
2011	1	1	2
2013	0	2	2
2014	0	2	2
2015	1	1	2
2017	2	1	3
2018	1	4	5
2020	0	2	2
2021	0	1	1
2022	0	3	3
2023	1	2	3
2024	2	2	4
2025	0	1	1

Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.

Chahdi A, Jorgez C, Rosenfeld JA, Neetu N, Seth A. Androgen receptor ubiquitination links KCTD13 to genitourinary tract defects. FASEB J. 2025 Feb 28; 39(4):e70406.

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Silverman RF, Francis JH, Robbins MA, Dunkel IJ, Abramson DH. RB1 CIRCULATING TUMOR DNA IN THE BLOOD OF PATIENTS WITH RETINOBLASTOMA INCREASES IN UNTREATED PATIENTS. Retina. 2024 12 01; 44(12):2123-2128.

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Di Cosimo S, Silvestri M, De Marco C, Calzoni A, De Santis MC, Carnevale MG, Reduzzi C, Cristofanilli M, Cappelletti V. Low-pass whole genome sequencing of circulating tumor cells to evaluate chromosomal instability in triple-negative breast cancer. Sci Rep. 2024 09 03; 14(1):20479.

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Alsoudi AF, Parvus MN, Pulido J, Chevez-Barrios P, Teh BS, Bernicker E, Miles S, Schefler A. MULTIPLYING BROWN SPOTS. Retin Cases Brief Rep. 2024 Sep 01; 18(5):642-646.

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Chahdi A, Jorgez C, Seth A. Regulation of androgen receptor stability by the ?1 Pix/STUB1 complex. FASEB J. 2024 02; 38(2):e23408.

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Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM. c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity. Nat Commun. 2023 11 04; 14(1):7098.

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Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. J Biol Chem. 2023 06; 299(6):104774.

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Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y. Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity. Sci Adv. 2023 01 06; 9(1):eadd6626.

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Merline R, R?dig H, Zeng-Brouwers J, Poluzzi C, Tascher G, Michaelis J, Lopez-Mosqueda J, Rhiner A, Huber LS, Diehl V, Dikic I, K?gel D, M?nch C, Wygrecka M, Schaefer L. A20 binding and inhibitor of nuclear factor kappa B (NF-?B)-1 (ABIN-1): a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol. 2023 02 01; 324(2):C339-C352.

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Seth A, Rivera A, Chahdi A, Choi IS, Medina-Martinez O, Lewis S, O'Neill M, Ridgeway A, Moore J, Jorgez C, Lamb DJ. Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function. FASEB J. 2022 11; 36(11):e22567.

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