Thomas Jefferson University

Diane Merry

TitleProfessor, SKMC
InstitutionThomas Jefferson University
DepartmentBiochemistry & Molecular Biology - Thomas Jefferson University
Address951 Locust Street
Philadelphia PA 19107
Phone2155034907
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    Collapse Research 
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    R01NS032214     (MERRY, DIANE E)Aug 1, 1994 - Jun 30, 2011
    NIH
    Polyglutamine Neurotoxicity in SBMA
    Role: Principal Investigator
    R56NS032214     (MERRY, DIANE E)Aug 1, 1994 - Jul 14, 2014
    NIH
    Polyglutamine Neurotoxicity in SBMA
    Role: Principal Investigator
    R29NS036248     (MERRY, DIANE E)Apr 1, 1997 - Jan 31, 2002
    NIH
    INTERACTIONS OF ANDROGEN RECEPTOR POLYGLUTAMINE TRACT
    Role: Principal Investigator
    R01NS047381     (MERRY, DIANE E)Jul 1, 2004 - Apr 30, 2008
    NIH
    Hormonal Control of SBMA Pathogenesis
    Role: Principal Investigator
    R21NS052542     (MERRY, DIANE E)Jul 15, 2005 - Jun 30, 2008
    NIH
    Huntington's Disease and the Striatum
    Role: Principal Investigator
    R13NS058219     (MERRY, DIANE E)Mar 1, 2007 - Feb 29, 2008
    NIH
    2007 CAG Triplet Repeat Disorders Gordon Conference
    Role: Principal Investigator
    R21NS057401     (MERRY, DIANE E)Jun 5, 2009 - May 31, 2011
    NIH
    Novel Therapeutic Approaches in SBMA
    Role: Principal Investigator
    R21NS071032     (MERRY, DIANE E)Jul 7, 2010 - Jun 30, 2012
    NIH
    Inhibiting the Androgen Receptor N/C Interaction to Treat SBMA
    Role: Principal Investigator
    R03NS075746     (MERRY, DIANE E)Jul 1, 2011 - Jun 30, 2013
    NIH
    The role of androgen receptor acetylation in the polyglutamine disease SBMA
    Role: Principal Investigator
    R01NS076919     (MERRY, DIANE E)Jul 1, 2011 - Dec 31, 2016
    NIH
    The Role of the AR N/C Interaction in SMBA
    Role: Principal Investigator
    R01NS090335     (MERRY, DIANE E)Jul 1, 2015 - Jun 30, 2020
    NIH
    Nuclear mechanisms of polyglutamine toxicity in SBMA
    Role: Principal Investigator
    R01NS108114     (MERRY, DIANE E)May 15, 2018 - Feb 29, 2024
    NIH
    The Role of the AR Interactome in SBMA
    Role: Principal Investigator
    R01NS108191     (MERRY, DIANE E)May 15, 2018 - Feb 29, 2024
    NIH
    The AR N/C interaction in SBMA - Mechanistic role and therapeutic potential
    Role: Principal Investigator
    R37NS108114     (MERRY, DIANE E)May 15, 2018 - Apr 30, 2028
    NIH
    The role of the AR interactome in SBMA
    Role: Principal Investigator
    R01NS106302     (MERRY, DIANE E)Sep 20, 2019 - Jul 31, 2024
    NIH
    Determining the role of AR transcriptional function in SBMA
    Role: Principal Investigator
    T32GM144302     (MERRY, DIANE E)Jul 1, 2022 - Jun 30, 2027
    NIH
    Training Grant in Cellular, Biochemical and Molecular Sciences
    Role: Principal Investigator
    R21NS135773     (MERRY, DIANE E)Sep 15, 2023 - Aug 31, 2025
    NIH
    Therapeutic strategies to rescue metabolic deficiencies in spinal and bulbar muscular atrophy
    Role: Principal Investigator
    R21NS139090     (MERRY, DIANE E)Jul 1, 2024 - Jun 30, 2026
    NIH
    The mechanism and role of androgen receptor Serine 16 phosphorylation in SBMA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Karliner J, Liu Y, Merry DE. Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2321408121. PMID: 38976730.
      Citations:    
    2. Lisberg A, Liu Y, Merry DE. Blocking the dimerization of polyglutamine-expanded androgen receptor protects cells from DHT-induced toxicity by increasing AR turnover. J Biol Chem. 2024 Mar 29; 107246. PMID: 38556081.
      Citations:    
    3. DeBartolo D, Arnold FJ, Liu Y, Molotsky E, Tang HY, Merry DE. Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy. JCI Insight. 2024 Mar 05. PMID: 38452174.
      Citations:    
    4. Richardson K, Sengupta M, Sujkowski A, Libohova K, Harris AC, Wessells R, Merry DE, Todi SV. A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila. J Neurosci Res. 2024 Jan; 102(1):e25278. PMID: 38284836.
      Citations:    
    5. Garcia Castro DR, Mazuk JR, Heine EM, Simpson D, Pinches RS, Lozzi C, Hoffman K, Morrin P, Mathis D, Lebedev MV, Nissley E, Han KH, Farmer T, Merry DE, Tong Q, Pennuto M, Montie HL. Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice. iScience. 2023 Aug 18; 26(8):107375. PMID: 37599829.
      Citations:    
    6. Karliner J, Merry DE. Differentiating PC12 cells to evaluate neurite densities through live-cell imaging. STAR Protoc. 2023 Jan 04; 4(1):101993. PMID: 36602900.
      Citations:    
    7. Sengupta M, Pluciennik A, Merry DE. The role of ubiquitination in spinal and bulbar muscular atrophy. Front Mol Neurosci. 2022; 15:1020143. PMID: 36277484.
      Citations:    
    8. Molotsky E, Liu Y, Lieberman AP, Merry DE. Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy. Acta Neuropathol Commun. 2022 Jul 05; 10(1):97. PMID: 35791011.
      Citations:    
    9. Pluciennik A, Liu Y, Molotsky E, Marsh GB, Ranxhi B, Arnold FJ, St-Cyr S, Davidson B, Pourshafie N, Lieberman AP, Gu W, Todi SV, Merry DE. Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy. J Clin Invest. 2021 Jan 04; 131(1). PMID: 33170804.
      Citations:    
    10. Arnold FJ, Merry DE. Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease. Neurotherapeutics. 2019 Nov 04. PMID: 31686397.
      Citations:    
    11. Arnold FJ, Pluciennik A, Merry DE. Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. Sci Rep. 2019 Jan 15; 9(1):119. PMID: 30644418.
      Citations:    
    12. Oh E, Liu Y, Sonar MV, Merry DE, Wickstrom E. Fluorescence Imaging of Huntingtin mRNA Knockdown. Bioconjug Chem. 2018 Feb 26. PMID: 29451775.
      Citations:    
    13. Yersak JM, Montie HL, Chevalier-Larsen ES, Liu Y, Huang L, Rechsteiner M, Merry DE. The 11S Proteasomal Activator REG? Impacts Polyglutamine-Expanded Androgen Receptor Aggregation and Motor Neuron Viability through Distinct Mechanisms. Front Mol Neurosci. 2017; 10:159. PMID: 28596723.
      Citations:    
    14. Bott LC, Salomons FA, Maric D, Liu Y, Merry D, Fischbeck KH, Dantuma NP. The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex. Sci Rep. 2016; 6:27703. PMID: 27312068.
      Citations:    
    15. Zboray L, Pluciennik A, Curtis D, Liu Y, Berman-Booty LD, Orr C, Kesler CT, Berger T, Gioeli D, Paschal BM, Merry DE. Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA. Cell Rep. 2015 Dec 15; 13(10):2312-23. PMID: 26673324.
      Citations:    
    16. Berger TR, Montie HL, Jain P, Legleiter J, Merry DE. Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy. Brain Res. 2015 Dec 2; 1628(Pt B):254-64. PMID: 26453288.
      Citations:    
    17. Heine EM, Berger TR, Pluciennik A, Orr CR, Zboray L, Merry DE. Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis. J Biol Chem. 2015 May 15; 290(20):12572-84. PMID: 25795778.
      Citations:    
    18. Ross JL, Tartaglia N, Merry DE, Dalva M, Zinn AR. Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features. Genes Brain Behav. 2015 Feb; 14(2):137-44. PMID: 25558953.
      Citations:    
    19. Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iñiguez-Lluhí JA, Lieberman AP. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease. J Clin Invest. 2015 Feb 2; 125(2):831-45. PMID: 25607844.
      Citations:    
    20. Hoang DT, Gu L, Liao Z, Shen F, Talati PG, Koptyra M, Tan SH, Ellsworth E, Gupta S, Montie H, Dagvadorj A, Savolainen S, Leiby B, Mirtti T, Merry DE, Nevalainen MT. Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer. Mol Cancer Ther. 2015 Mar; 14(3):713-26. PMID: 25552366.
      Citations:    
    21. Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. Hum Mol Genet. 2014 Mar 1; 23(5):1376-86. PMID: 24150846.
      Citations:    
    22. Cooper LJ, Merry DE. Cell Biological Approaches to Investigate Polyglutamine-Expanded AR Metabolism. Methods Mol Biol. 2013; 1017:241-53. PMID: 23719921.
      Citations:    
    23. Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2012 Dec 9; 9(2):112-8. PMID: 23222885.
      Citations:    
    24. Merry DE. Attacking the flank: targeting new pathways in SBMA. Nat Med. 2012 Oct; 18(10):1461-3. PMID: 23042346.
      Citations:    
    25. Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR. A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability. Hum Mol Genet. 2012 Oct 1; 21(19):4225-36. PMID: 22736030.
      Citations:    
    26. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
      Citations:    
    27. Montie HL, Pestell RG, Merry DE. SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. J Neurosci. 2011 Nov 30; 31(48):17425-36. PMID: 22131404.
      Citations:    
    28. Chevalier-Larsen ES, Merry DE. Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy. Dis Model Mech. 2012 Jan; 5(1):141-5. PMID: 21954065.
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    29. Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE. An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. J Biol Chem. 2010 Nov 12; 285(46):35567-77. PMID: 20826791.
      Citations:    
    30. Montie HL, Merry DE. Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA. Autophagy. 2009 Nov; 5(8):1194-7. PMID: 19770590.
      Citations:    
    31. Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47. PMID: 19553463.
      Citations:    
    32. Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE. Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet. 2009 Jun 1; 18(11):1937-50. PMID: 19279159.
      Citations:    
    33. Schiewer MJ, Morey LM, Burd CJ, Liu Y, Merry DE, Ho SM, Knudsen KE. Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer. Oncogene. 2009 Feb 19; 28(7):1016-27. PMID: 19079343; PMCID: PMC2852245.
      Citations:    
    34. Yang Z, Chang YJ, Yu IC, Yeh S, Wu CC, Miyamoto H, Merry DE, Sobue G, Chen LM, Chang SS, Chang C. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007 Mar; 13(3):348-53. PMID: 17334372.
      Citations:    
    35. Li M, Chevalier-Larsen ES, Merry DE, Diamond MI. Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy. J Biol Chem. 2007 Feb 2; 282(5):3157-64. PMID: 17121819.
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    36. Merry DE. Animal models of Kennedy disease. NeuroRx. 2005 Jul; 2(3):471-9. PMID: 16389310.
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    37. Chevalier-Larsen ES, O'Brien CJ, Wang H, Jenkins SC, Holder L, Lieberman AP, Merry DE. Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy. J Neurosci. 2004 May 19; 24(20):4778-86. PMID: 15152038.
      Citations:    
    38. Mandrusiak LM, Beitel LK, Wang X, Scanlon TC, Chevalier-Larsen E, Merry DE, Trifiro MA. Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor. Hum Mol Genet. 2003 Jul 1; 12(13):1497-506. PMID: 12812978.
      Citations:    
    39. Chan HY, Warrick JM, Andriola I, Merry D, Bonini NM. Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum Mol Genet. 2002 Nov 1; 11(23):2895-904. PMID: 12393801.
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    40. Walcott JL, Merry DE. Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy. J Biol Chem. 2002 Dec 27; 277(52):50855-9. PMID: 12388541.
      Citations:    
    41. Luthi-Carter R, Strand AD, Hanson SA, Kooperberg C, Schilling G, La Spada AR, Merry DE, Young AB, Ross CA, Borchelt DR, Olson JM. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. Hum Mol Genet. 2002 Aug 15; 11(17):1927-37. PMID: 12165555.
      Citations:    
    42. Bailey CK, Andriola IF, Kampinga HH, Merry DE. Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy. Hum Mol Genet. 2002 Mar 1; 11(5):515-23. PMID: 11875046.
      Citations:    
    43. Walcott JL, Merry DE. Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy. Vitam Horm. 2002; 65:127-47. PMID: 12481545.
      Citations:    
    44. Merry DE. Molecular pathogenesis of spinal and bulbar muscular atrophy. Brain Res Bull. 2001 Oct-Nov 1; 56(3-4):203-7. PMID: 11719251.
      Citations:    
    45. Abel A, Walcott J, Woods J, Duda J, Merry DE. Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice. Hum Mol Genet. 2001 Jan 15; 10(2):107-16. PMID: 11152658.
      Citations:    
    46. McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH. CREB-binding protein sequestration by expanded polyglutamine. Hum Mol Genet. 2000 Sep 01; 9(14):2197-202. PMID: 10958659.
      Citations:    
    47. Nakamura M, Raghupathi R, Merry DE, Scherbel U, Saatman KE, Mcintosh TK. Overexpression of Bcl-2 is neuroprotective after experimental brain injury in transgenic mice. J Comp Neurol. 1999 Oct 04; 412(4):681-92. PMID: 10464363.
      Citations:    
    48. Fischbeck KH, Lieberman A, Bailey CK, Abel A, Merry DE. Androgen receptor mutation in Kennedy's disease. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29; 354(1386):1075-8. PMID: 10434308.
      Citations:    
    49. Kobayashi Y, Miwa S, Merry DE, Kume A, Mei L, Doyu M, Sobue G. Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner. Biochem Biophys Res Commun. 1998 Nov 09; 252(1):145-50. PMID: 9813160.
      Citations:    
    50. Li M, Nakagomi Y, Kobayashi Y, Merry DE, Tanaka F, Doyu M, Mitsuma T, Hashizume Y, Fischbeck KH, Sobue G. Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy. Am J Pathol. 1998 Sep; 153(3):695-701. PMID: 9736019.
      Citations:    
    51. Li M, Miwa S, Kobayashi Y, Merry DE, Yamamoto M, Tanaka F, Doyu M, Hashizume Y, Fischbeck KH, Sobue G. Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy. Ann Neurol. 1998 Aug; 44(2):249-54. PMID: 9708548.
      Citations:    
    52. Merry DE, Kobayashi Y, Bailey CK, Taye AA, Fischbeck KH. Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy. Hum Mol Genet. 1998 Apr; 7(4):693-701. PMID: 9499423.
      Citations:    
    53. Brooks BP, Merry DE, Paulson HL, Lieberman AP, Kolson DL, Fischbeck KH. A cell culture model for androgen effects in motor neurons. J Neurochem. 1998 Mar; 70(3):1054-60. PMID: 9489725.
      Citations:    
    54. Brooks BP, Paulson HL, Merry DE, Salazar-Grueso EF, Brinkmann AO, Wilson EM, Fischbeck KH. Characterization of an expanded glutamine repeat androgen receptor in a neuronal cell culture system. Neurobiol Dis. 1997; 3(4):313-23. PMID: 9173928.
      Citations:    
    55. Koshy B, Matilla T, Burright EN, Merry DE, Fischbeck KH, Orr HT, Zoghbi HY. Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase. Hum Mol Genet. 1996 Sep; 5(9):1311-8. PMID: 8872471.
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    56. Pekosz A, Phillips J, Pleasure D, Merry D, Gonzalez-Scarano F. Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J Virol. 1996 Aug; 70(8):5329-35. PMID: 8764043.
      Citations:    
    57. Bingham PM, Scott MO, Wang S, McPhaul MJ, Wilson EM, Garbern JY, Merry DE, Fischbeck KH. Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice. Nat Genet. 1995 Feb; 9(2):191-6. PMID: 7719348.
      Citations:    
    58. Batistatou A, Merry DE, Korsmeyer SJ, Greene LA. Bcl-2 affects survival but not neuronal differentiation of PC12 cells. J Neurosci. 1993 Oct; 13(10):4422-8. PMID: 7692014.
      Citations:    
    59. Merry DE, J?nne PA, Landers JE, Lewis RA, Nussbaum RL. Isolation of a candidate gene for choroideremia. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2135-9. PMID: 1549574.
      Citations:    
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