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Koichi Iijima

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentFIN
Address900 Walnut Street
Philadelphia PA 19107
Phone215-238-0398
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Amyloid-ß plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC Neurosci. 2019 Mar 20; 20(1):13. PMID: 30894120.
      View in: PubMed
    2. Chiku T, Hayashishita M, Saito T, Oka M, Shinno K, Ohtake Y, Shimizu S, Asada A, Hisanaga SI, Iijima KM, Ando K. S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy. Neurobiol Aging. 2018 Nov; 71:255-264. PMID: 30172839.
      View in: PubMed
    3. Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of Aß amyloidosis. BMC Neurosci. 2018 Jul 28; 19(1):46. PMID: 30055565.
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    4. Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aß42, Tau, TREM2, and TYROBP in Drosophila models. Genome Med. 2018 Mar 29; 10(1):26. PMID: 29598827.
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    5. Sakakibara Y, Sekiya M, Fujisaki N, Quan X, Iijima KM. Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. PLoS Genet. 2018 Jan; 14(1):e1007196. PMID: 29357349.
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    6. Satoh A, Iijima KM. Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer's disease pathogenesis: Potential strategies to protect the LC against aging. Brain Res. 2017 Dec 21. PMID: 29274876.
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    7. Oka M, Fujisaki N, Maruko-Otake A, Ohtake Y, Shimizu S, Saito T, Hisanaga SI, Iijima KM, Ando K. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. J Biochem. 2017 Nov 01; 162(5):335-342. PMID: 28992057.
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    8. Sekiya M, Maruko-Otake A, Hearn S, Sakakibara Y, Fujisaki N, Suzuki E, Ando K, Iijima KM. EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila. Dev Cell. 2017 Jun 19; 41(6):652-664.e5. PMID: 28633019.
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    9. Ando K, Oka M, Ohtake Y, Hayashishita M, Shimizu S, Hisanaga S, Iijima KM. Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochem Biophys Res Commun. 2016 Sep 16; 478(2):929-34. PMID: 27520376.
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    10. Ando K, Maruko-Otake A, Ohtake Y, Hayashishita M, Sekiya M, Iijima KM. Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aß42-Induced Tau Toxicity. PLoS Genet. 2016 Mar; 12(3):e1005917. PMID: 27023670.
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    11. Mendoza J, Sekiya M, Taniguchi T, Iijima KM, Wang R, Ando K. Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro. J Proteome Res. 2013 Jun 7; 12(6):2654-65. PMID: 23550703.
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    12. Iijima-Ando K, Sekiya M, Maruko-Otake A, Ohtake Y, Suzuki E, Lu B, Iijima KM. Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. PLoS Genet. 2012; 8(8):e1002918. PMID: 22952452.
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    13. Iijima K, Gatt A, Iijima-Ando K. Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet. 2010 Aug 1; 19(15):2947-57. PMID: 20466736.
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    14. Iijima-Ando K, Zhao L, Gatt A, Shenton C, Iijima K. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration. Hum Mol Genet. 2010 May 15; 19(10):1930-8. PMID: 20159774.
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    15. Iijima K, Zhao L, Shenton C, Iijima-Ando K. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS One. 2009; 4(12):e8498. PMID: 20041126.
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    16. Iijima-Ando K, Hearn SA, Shenton C, Gatt A, Zhao L, Iijima K. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease. PLoS One. 2009; 4(12):e8310. PMID: 20016833.
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    17. Iijima-Ando K, Iijima K. Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct Funct. 2010 Mar; 214(2-3):245-62. PMID: 19967412.
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    18. Iijima K, Iijima-Ando K. Drosophila models of Alzheimer's amyloidosis: the challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. J Alzheimers Dis. 2008 Dec; 15(4):523-40. PMID: 19096154.
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    19. Iijima-Ando K, Hearn SA, Granger L, Shenton C, Gatt A, Chiang HC, Hakker I, Zhong Y, Iijima K. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. J Biol Chem. 2008 Jul 4; 283(27):19066-76. PMID: 18463098.
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    20. Iijima K, Chiang HC, Hearn SA, Hakker I, Gatt A, Shenton C, Granger L, Leung A, Iijima-Ando K, Zhong Y. Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS One. 2008; 3(2):e1703. PMID: 18301778.
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