"Alcohol Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
| Descriptor ID |
D000426
|
| MeSH Number(s) |
D08.811.682.047.820.250
|
| Concept/Terms |
Alcohol Dehydrogenase- Alcohol Dehydrogenase
- Dehydrogenase, Alcohol
- Alcohol-NAD+ Oxidoreductase
- Alcohol NAD+ Oxidoreductase
- Oxidoreductase, Alcohol-NAD+
- Alcohol Dehydrogenase (NAD+)
|
Below are MeSH descriptors whose meaning is more general than "Alcohol Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Alcohol Dehydrogenase".
This graph shows the total number of publications written about "Alcohol Dehydrogenase" by people in this website by year, and whether "Alcohol Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alcohol Dehydrogenase" by people in Profiles.
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Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry. 2012 May 22; 51(20):4147-56.
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Lee J, Jang YS, Choi SJ, Im JA, Song H, Cho JH, Seung do Y, Papoutsakis ET, Bennett GN, Lee SY. Metabolic engineering of Clostridium acetobutylicum ATCC 824 for isopropanol-butanol-ethanol fermentation. Appl Environ Microbiol. 2012 Mar; 78(5):1416-23.
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Karahanian E, Quintanilla ME, Tampier L, Rivera-Meza M, Bustamante D, Gonzalez-Lira V, Morales P, Herrera-Marschitz M, Israel Y. Ethanol as a prodrug: brain metabolism of ethanol mediates its reinforcing effects. Alcohol Clin Exp Res. 2011 Apr; 35(4):606-12.
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Israel Y, Rivera-Meza M, Quintanilla ME, Sapag A, Tampier L. Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? Alcohol Clin Exp Res. 2011 May; 35(5):806-10.
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Lee JY, Jang YS, Lee J, Papoutsakis ET, Lee SY. Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production. Biotechnol J. 2009 Oct; 4(10):1432-40.
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Rivera-Meza M, Quintanilla ME, Tampier L, Mura CV, Sapag A, Israel Y. Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. FASEB J. 2010 Jan; 24(1):266-74.
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Tampier L, Quintanilla ME, Israel Y. Tolerance to disulfiram induced by chronic alcohol intake in the rat. Alcohol Clin Exp Res. 2008 Jun; 32(6):937-41.
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Quintanilla ME, Tampier L, Sapag A, Gerdtzen Z, Israel Y. Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2):E531-7.
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Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding. Biochemistry. 2004 May 11; 43(18):5266-77.
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Tummala SB, Junne SG, Papoutsakis ET. Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations. J Bacteriol. 2003 Jun; 185(12):3644-53.