"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
Descriptor ID |
D001905
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MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
|
Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
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Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2000 | 2 | 0 | 2 |
2002 | 2 | 0 | 2 |
2003 | 2 | 2 | 4 |
2004 | 1 | 0 | 1 |
2005 | 2 | 1 | 3 |
2006 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2008 | 2 | 1 | 3 |
2009 | 2 | 1 | 3 |
2011 | 1 | 1 | 2 |
2013 | 1 | 0 | 1 |
2015 | 0 | 1 | 1 |
2016 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2020 | 1 | 0 | 1 |
2023 | 1 | 0 | 1 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Gollomp SM, Khalifian S, Gokhale S. Mitigating Immunogenicity by Coordinating Botulinum Toxin Treatments Between Aesthetics and Therapeutics. Dermatol Surg. 2024 Sep 01; 50(9S):S35-S37.
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Sattler S, Gollomp S, Curry A. A Narrative Literature Review of the Established Safety of Human Serum Albumin Use as a Stabilizer in Aesthetic Botulinum Toxin Formulations Compared to Alternatives. Toxins (Basel). 2023 10 18; 15(10).
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Barbarite E, Shaye D, Oyer S, Lee LN. Quality Assessment of Online Patient Information for Cosmetic Botulinum Toxin. Aesthet Surg J. 2020 10 24; 40(11):NP636-NP642.
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O'Connell Ferster AP, Sataloff RT, Shewokis PA, Hu A. Socioeconomic Variables of Patients with Spasmodic Dysphonia: A Preliminary Study. J Voice. 2018 Jul; 32(4):479-483.
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Narayanaswami P, Geisbush T, Tarulli A, Raynor E, Gautam S, Tarsy D, Gronseth G. Drooling in Parkinson's disease: A randomized controlled trial of incobotulinum toxin A and meta-analysis of Botulinum toxins. Parkinsonism Relat Disord. 2016 09; 30:73-7.
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Lavrich JB. Intermittent exotropia: continued controversies and current management. Curr Opin Ophthalmol. 2015 Jul; 26(5):375-81.
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Kelly EA, Koszewski IJ, Jaradeh SS, Merati AL, Blumin JH, Bock JM. Botulinum toxin injection for the treatment of upper esophageal sphincter dysfunction. Ann Otol Rhinol Laryngol. 2013 Feb; 122(2):100-8.
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Singh J, Maxwell PJ, Rattan S. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G317-25.
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Fehlings MG, Theodore N, Harrop J, Maurais G, Kuntz C, Shaffrey CI, Kwon BK, Chapman J, Yee A, Tighe A, McKerracher L. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011 May; 28(5):787-96.
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Elovic EP, Esquenazi A, Alter KE, Lin JL, Alfaro A, Kaelin DL. Chemodenervation and nerve blocks in the diagnosis and management of spasticity and muscle overactivity. PM R. 2009 Sep; 1(9):842-51.