"Calpain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
| Descriptor ID |
D002154
|
| MeSH Number(s) |
D08.811.277.656.262.500.120 D08.811.277.656.300.200.120
|
| Concept/Terms |
Calpain- Calpain
- Calcium-Activated Protease
- Calcium Activated Protease
- Protease, Calcium-Activated
- Calcium-Dependent Neutral Proteinase
- Calcium Dependent Neutral Proteinase
- Neutral Proteinase, Calcium-Dependent
- Proteinase, Calcium-Dependent Neutral
- Calcium-Dependent Neutral Protease
- Calcium Dependent Neutral Protease
- Neutral Protease, Calcium-Dependent
- Protease, Calcium-Dependent Neutral
- Desminase
- Ca2+-Activated Protease
- Ca2+ Activated Protease
- Protease, Ca2+-Activated
- Calcium-Activated Neutral Proteinase
- Calcium Activated Neutral Proteinase
- Neutral Proteinase, Calcium-Activated
- Proteinase, Calcium-Activated Neutral
- Calcium-Activated Neutral Protease
- Calcium Activated Neutral Protease
- Neutral Protease, Calcium-Activated
- Protease, Calcium-Activated Neutral
|
Below are MeSH descriptors whose meaning is more general than "Calpain".
Below are MeSH descriptors whose meaning is more specific than "Calpain".
This graph shows the total number of publications written about "Calpain" by people in this website by year, and whether "Calpain" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Calpain" by people in Profiles.
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Zhu J, Jin M, Wang J, Zhang H, Wu Y, Li D, Ji X, Yang H, Yin C, Ren T, Xing J. TNFa induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2018 Mar 05; 37(1):43.
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Smolock AR, Mishra G, Eguchi K, Eguchi S, Scalia R. Protein kinase C upregulates intercellular adhesion molecule-1 and leukocyte-endothelium interactions in hyperglycemia via activation of endothelial expressed calpain. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):289-96.
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Singh N, Shrivastav A, Olson D, Lakshmikuttyamma A, Ross A, Parr T, Bardsley RG, Sharma RK. Cardiac high molecular weight calmodulin-binding protein is homologous to calpastatin I and calpastatin II. Biochem Biophys Res Commun. 2008 Aug 29; 373(3):387-91.
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Lakshmikuttyamma A, Selvakumar P, Charavaryamath C, Singh B, Tuchek J, Sharma RK. Expression of calcineurin and its interacting proteins in epileptic fowl. J Neurochem. 2006 Jan; 96(2):366-73.
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Stalker TJ, Gong Y, Scalia R. The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes. 2005 Apr; 54(4):1132-40.
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Lakshmikuttyamma A, Selvakumar P, Sharma AR, Anderson DH, Sharma RK. In vitro proteolytic degradation of bovine brain calcineurin by m-calpain. Neurochem Res. 2004 Oct; 29(10):1913-21.
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Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. Overexpression of m-calpain in human colorectal adenocarcinomas. Cancer Epidemiol Biomarkers Prev. 2004 Oct; 13(10):1604-9.
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Lakshmikuttyamma A, Selvakumar P, Kakkar R, Kanthan R, Wang R, Sharma RK. Activation of calcineurin expression in ischemia-reperfused rat heart and in human ischemic myocardium. J Cell Biochem. 2003 Dec 1; 90(5):987-97.
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Stalker TJ, Skvarka CB, Scalia R. A novel role for calpains in the endothelial dysfunction of hyperglycemia. FASEB J. 2003 Aug; 17(11):1511-3.
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Saatman KE, Abai B, Grosvenor A, Vorwerk CK, Smith DH, Meaney DF. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. J Cereb Blood Flow Metab. 2003 Jan; 23(1):34-42.