Citric Acid Cycle

"Citric Acid Cycle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A series of oxidative reactions in the breakdown of acetyl units derived from GLUCOSE; FATTY ACIDS; or AMINO ACIDS by means of tricarboxylic acid intermediates. The end products are CARBON DIOXIDE, water, and energy in the form of phosphate bonds.

Descriptor ID	D002952
MeSH Number(s)	G02.111.165 G03.295.342 G03.493.170
Concept/Terms	Citric Acid Cycle Citric Acid Cycle Citric Acid Cycles Cycle, Citric Acid Cycles, Citric Acid Tricarboxylic Acid Cycle Cycle, Tricarboxylic Acid Cycles, Tricarboxylic Acid Tricarboxylic Acid Cycles Krebs Cycle Cycle, Krebs

Below are MeSH descriptors whose meaning is more general than "Citric Acid Cycle".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Citric Acid Cycle [G02.111.165]
Metabolism [G03]
Energy Metabolism [G03.295]
Citric Acid Cycle [G03.295.342]
Metabolic Networks and Pathways [G03.493]
Citric Acid Cycle [G03.493.170]

Below are MeSH descriptors whose meaning is related to "Citric Acid Cycle".

Below are MeSH descriptors whose meaning is more specific than "Citric Acid Cycle".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Citric Acid Cycle" by people in this website by year, and whether "Citric Acid Cycle" was a major or minor topic of these publications.

Bar chart showing 19 publications over 12 distinct years, with a maximum of 3 publications in 2015 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	1	2
2003	1	0	1
2004	0	2	2
2010	1	0	1
2011	0	2	2
2013	0	1	1
2014	0	1	1
2015	0	3	3
2016	0	1	1
2017	1	0	1
2020	0	1	1
2024	1	2	3

Below are the most recent publications written about "Citric Acid Cycle" by people in Profiles.

Ritterhoff J, McMillen T, Foundas H, Palkovacs R, Poschet G, Caudal A, Liu Y, Most P, Walker M, Tian R. 13C stable isotope tracing reveals distinct fatty acid oxidation pathways in proliferative versus oxidative cells. Am J Physiol Cell Physiol. 2025 Jan 01; 328(1):C168-C178.

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Hlavaty SI, Salcido KN, Pniewski KA, Mukha D, Ma W, Kannan T, Cassel J, Srikanth YVV, Liu Q, Kossenkov A, Salvino JM, Chen Q, Schug ZT. ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis. Cell Rep. 2024 12 24; 43(12):114988.

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Zarei M, Hajihassani O, Hue JJ, Loftus AW, Graor HJ, Nakazzi F, Naji P, Boutros CS, Uppin V, Vaziri-Gohar A, Shalaby AS, Asara JM, Rothermel LD, Brody JR, Winter JM. IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer. Cancer Res. 2024 Sep 16; 84(18):3072-3085.

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Bennett RK, Dillon M, Gerald Har JR, Agee A, von Hagel B, Rohlhill J, Antoniewicz MR, Papoutsakis ET. Engineering Escherichia coli for methanol-dependent growth on glucose for metabolite production. Metab Eng. 2020 07; 60:45-55.

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Peters JM. Flipping a citrate switch on liver cancer cells. J Biol Chem. 2017 08 18; 292(33):13902-13903.

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Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR, Calabretta B, Salomoni P, Gottlieb E, Holyoake TL, Helgason GV. ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells. Autophagy. 2016 06 02; 12(6):936-48.

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Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD. Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem. 2016 Mar 04; 291(10):5157-71.

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Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 01; 291(1):42-57.

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Tavecchio M, Lisanti S, Bennett MJ, Languino LR, Altieri DC. Deletion of Cyclophilin D Impairs ?-Oxidation and Promotes Glucose Metabolism. Sci Rep. 2015 Oct 30; 5:15981.

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Adijanto J, Du J, Moffat C, Seifert EL, Hurle JB, Philp NJ. The retinal pigment epithelium utilizes fatty acids for ketogenesis. J Biol Chem. 2014 Jul 25; 289(30):20570-82.

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