Diphtheria Toxin

"Diphtheria Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

Descriptor ID	D004167
MeSH Number(s)	D08.811.913.400.725.115.220 D23.946.123.305
Concept/Terms	Diphtheria Toxin Diphtheria Toxin Toxin, Corynebacterium Diphtheriae Corynebacterium Diphtheriae Toxin

Below are MeSH descriptors whose meaning is more general than "Diphtheria Toxin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Glycosyltransferases [D08.811.913.400]
Pentosyltransferases [D08.811.913.400.725]
ADP Ribose Transferases [D08.811.913.400.725.115]
Diphtheria Toxin [D08.811.913.400.725.115.220]
Biological Factors [D23]
Toxins, Biological [D23.946]
Bacterial Toxins [D23.946.123]
Diphtheria Toxin [D23.946.123.305]

Below are MeSH descriptors whose meaning is related to "Diphtheria Toxin".

Below are MeSH descriptors whose meaning is more specific than "Diphtheria Toxin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Diphtheria Toxin" by people in this website by year, and whether "Diphtheria Toxin" was a major or minor topic of these publications.

Bar chart showing 17 publications over 11 distinct years, with a maximum of 4 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2004	0	2	2
2005	2	0	2
2007	4	0	4
2008	1	0	1
2009	1	1	2
2012	1	0	1
2013	1	0	1
2014	1	0	1
2015	0	1	1
2017	1	0	1

Below are the most recent publications written about "Diphtheria Toxin" by people in Profiles.

Bhopale MK, Hilliard B, Constantinescu CS, Phillips SM, Rostami A. DAB389IL-2 recombinant fusion toxin effect on lymphocyte- and macrophage-producing cytokine subpopulation cells in experimentally induced demyelinating disease in mice. Immunopharmacol Immunotoxicol. 2017 Dec; 39(6):318-329.

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Gooptu M, Rhoades R, Pro B. Current management of peripheral T-cell lymphomas. Cancer Treat Res. 2015; 165:289-303.

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Tholey RM, Lal S, Jimbo M, Burkhart RA, Blanco FF, Cozzitorto JA, Eisenberg JD, Jiang W, Iacobuzio-Donahue CA, Witkiewicz AK, Glbert M, Yeo CJ, Brody JR, Sawicki JA, Winter JM. MUC1 Promoter-Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer. Mol Cancer Res. 2015 Mar; 13(3):439-48.

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Bhopale MK, Hilliard B, Constantinescu CS, Fujioka T, Ventura E, Phillips SM, Rostami A. DAB389IL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells. Exp Mol Pathol. 2014 Feb; 96(1):108-17.

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Peng W, Dunton C, Holtz D, Parva M, Stampler K, Forwood M, Gogoi R, Lace MJ, Anderson DG, Sawicki JA. DNA nanotherapy for pre-neoplastic cervical lesions. Gynecol Oncol. 2013 Jan; 128(1):101-106.

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Phillips SM, Bhopale MK, Hilliard B, Zekavat SA, Ali MA, Rostami A. Suppression of murine experimental autoimmune encephalomyelitis by interleukin-2 receptor targeted fusion toxin, DAB(389)IL-2. Cell Immunol. 2010; 261(2):144-52.

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Brodzik R, Spitsin S, Pogrebnyak N, Bandurska K, Portocarrero C, Andryszak K, Koprowski H, Golovkin M. Generation of plant-derived recombinant DTP subunit vaccine. Vaccine. 2009 Jun 08; 27(28):3730-4.

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Showalter SL, Huang YH, Witkiewicz A, Costantino CL, Yeo CJ, Green JJ, Langer R, Anderson DG, Sawicki JA, Brody JR. Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Cancer Biol Ther. 2008 Oct; 7(10):1584-90.

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Phillips SM, Bhopale MK, Constantinescu CS, Ciric B, Hilliard B, Ventura E, Lavi E, Rostami A. Effect of DAB(389)IL-2 immunotoxin on the course of experimental autoimmune encephalomyelitis in Lewis rats. J Neurol Sci. 2007 Dec 15; 263(1-2):59-69.

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Dang NH, Fayad L, McLaughlin P, Romaguara JE, Hagemeister F, Goy A, Neelapu S, Samaniego F, Walker PL, Wang M, Rodriguez MA, Tong AT, Pro B. Phase II trial of the combination of denileukin diftitox and rituximab for relapsed/refractory B-cell non-Hodgkin lymphoma. Br J Haematol. 2007 Aug; 138(4):502-5.

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